東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

FindBook

Google Book

Amazon

博客來

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer./
作者:	Gutierrez, Allan E. .
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2023,
面頁冊數:	36 p.
附註:	Source: Masters Abstracts International, Volume: 85-02.
Contained By:	Masters Abstracts International85-02.
標題:	Pharmaceutical sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30531136
ISBN:	9798379969066

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer.
Gutierrez, Allan E. .

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer. - Ann Arbor : ProQuest Dissertations & Theses, 2023 - 36 p.

Source: Masters Abstracts International, Volume: 85-02.

Thesis (M.S.)--University of South Florida, 2023.

Lung cancer is one of the most prevalent and high mortality cancers in the world. Two different categories of lung cancer are non-small cell lung cancer which makes up 85% of cases, and small cell lung cancer which makes up the remaining 15% of cases. A significant risk factor that can lead to lung cancer is cigarette smoking (CS) however non-smoking cases i.e., secondhand CS, exposure to certain toxins and family history are on the rise. Both the main types of lung cancer have different system of stages, different ranges of treatment, and consequently low survival rates. Unfortunately, detection and confirmation usually are determined at stage four (IV) where the current treatments used are invasive with poor patient outcomes. Combined chemotherapy and radiation therapy are the primary treatment however have severe side effects as delivery of anticancer compounds to neoplastic tissue is important to limit toxicity as a result to targeting healthy cells. The demand for alternative treatment with minimal side effects is needed. Nanotechnology plays a role in enhancing efficient delivery of anticancer drug to the affected tissues by increasing the efficacy and reducing side effects. Presently, nanocarriers (NCs) have gained huge attention for their structural ability, good biocompatibility, and biodegradability. NCs fundamental goal is to tackle the delivery-related problems associated with standard chemo or radiation therapy and to carry medicines to the intended sites of action while avoiding undesirable side effects. Evidence suggest nanodiamonds (NDs) are potential new NCs for treatment for lung cancer. The objective of this study is to functionalize NDs as potential nano-drug carrier for gene therapy with minimized side effects and injury to health normal lung cells as well as to evaluate the functionalized properties of NDs as potential NCs for cancer gene therapy. We plan to purify commercial-graded NDs via acid wash and conduct functionalization studies utilizing Fourier transform infrared spectroscopy (FTIR). The A549, human epithelial cancer cell line will, be used to demonstrate NDs potential for safe and effective NCs that can be used for future gene therapy targeting the tumor microenvironment.

ISBN: 9798379969066Subjects--Topical Terms:

3173021
Pharmaceutical sciences.
Subjects--Index Terms:

Gene therapy

Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer.
LDR:03382nmm a2200385 4500 001 2365932
005 20240918072807.5
006 m o d
007 cr#unu||||||||
008 241017s2023 ||||||||||||||||| ||eng d
020 $a 9798379969066
035 $a (MiAaPQ)AAI30531136
035 $a AAI30531136
040 $a MiAaPQ $c MiAaPQ
100 1 $a Gutierrez, Allan E. . $3 3707210
245 1 0 $a Utilization of Detonation Nanodiamonds: Nanocarrier for Gene Therapy in Non-Small Cell Lung Cancer.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2023
300 $a 36 p.
500 $a Source: Masters Abstracts International, Volume: 85-02.
500 $a Advisor: Allen-Gipson, Diane.
502 $a Thesis (M.S.)--University of South Florida, 2023.
520 $a Lung cancer is one of the most prevalent and high mortality cancers in the world. Two different categories of lung cancer are non-small cell lung cancer which makes up 85% of cases, and small cell lung cancer which makes up the remaining 15% of cases. A significant risk factor that can lead to lung cancer is cigarette smoking (CS) however non-smoking cases i.e., secondhand CS, exposure to certain toxins and family history are on the rise. Both the main types of lung cancer have different system of stages, different ranges of treatment, and consequently low survival rates. Unfortunately, detection and confirmation usually are determined at stage four (IV) where the current treatments used are invasive with poor patient outcomes. Combined chemotherapy and radiation therapy are the primary treatment however have severe side effects as delivery of anticancer compounds to neoplastic tissue is important to limit toxicity as a result to targeting healthy cells. The demand for alternative treatment with minimal side effects is needed. Nanotechnology plays a role in enhancing efficient delivery of anticancer drug to the affected tissues by increasing the efficacy and reducing side effects. Presently, nanocarriers (NCs) have gained huge attention for their structural ability, good biocompatibility, and biodegradability. NCs fundamental goal is to tackle the delivery-related problems associated with standard chemo or radiation therapy and to carry medicines to the intended sites of action while avoiding undesirable side effects. Evidence suggest nanodiamonds (NDs) are potential new NCs for treatment for lung cancer. The objective of this study is to functionalize NDs as potential nano-drug carrier for gene therapy with minimized side effects and injury to health normal lung cells as well as to evaluate the functionalized properties of NDs as potential NCs for cancer gene therapy. We plan to purify commercial-graded NDs via acid wash and conduct functionalization studies utilizing Fourier transform infrared spectroscopy (FTIR). The A549, human epithelial cancer cell line will, be used to demonstrate NDs potential for safe and effective NCs that can be used for future gene therapy targeting the tumor microenvironment.
590 $a School code: 0206.
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Oncology. $3 751006
650 4 $a Nanoscience. $3 587832
653 $a Gene therapy
653 $a Nanodiamonds
653 $a Cigarette smoking
653 $a Chemotherapy
653 $a Lung cancer
690 $a 0572
690 $a 0565
690 $a 0992
710 2 $a University of South Florida. $b Biology (Cell Biology, Microbiology, Molecular Biology). $3 2100351
773 0 $t Masters Abstracts International $g 85-02.
790 $a 0206
791 $a M.S.
792 $a 2023
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30531136