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Neurobiological Mechanisms Involved in the Relationship Between Loneliness, Depression, and Cognitive Decline in Older Adults.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Neurobiological Mechanisms Involved in the Relationship Between Loneliness, Depression, and Cognitive Decline in Older Adults./
Author:	Dabiri, Sanaz.
Description:	1 online resource (126 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-10, Section: A.
Contained By:	Dissertations Abstracts International84-10A.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30424009click for full text (PQDT)
ISBN:	9798379428624

Neurobiological Mechanisms Involved in the Relationship Between Loneliness, Depression, and Cognitive Decline in Older Adults.
Dabiri, Sanaz.

Neurobiological Mechanisms Involved in the Relationship Between Loneliness, Depression, and Cognitive Decline in Older Adults. - 1 online resource (126 pages)

Source: Dissertations Abstracts International, Volume: 84-10, Section: A.

Thesis (Ph.D.)--Howard University, 2022.

Includes bibliographical references

Loneliness, among older adults, is one of the risk factors for developing dementia. Still, little is known about the neurobiological and psychological conditions that link loneliness to cognitive decline. The current study was intended to address several research aims: First, it sought to determine whether the relationship between loneliness and cognitive decline is sex-specific in older adults. Second, it sought to identify neurobiological and psychological pathways that may account for the relationship between loneliness and decline across several cognitive domains. These pathways included depressive symptoms, gray and white matter volume, and conditional analyses of pro-inflammatory cytokines and brain-derived neurotrophic factor (BDNF) expression. Third, it examined loneliness as a predictor of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal data were collected from 2130 Rush Memory and Aging ProjectMAP participants. Participants underwent annual cognitive and psychological assessments, as well as neuroimaging procedures every year. BDNF gene expression was measured in the dorsolateral prefrontal cortex, and the final clinical diagnosis was identified upon autopsy at death. Linear mixed models and multinomial logistic regression analyses were used to measure serum samples of pro-inflammatory cytokines All models controlled for age at baseline, education, and sex. Participants were largely women (73%), and Caucasian (93%). The average education was 14.93 (SD=3.34). The average age at baseline was 80.05 (SD=7.57). Results showed that gray matter volume and depressive symptoms partially mediated the relationship between loneliness and cognitive decline. BDNF expression was positively related to cognitive performance, and its interaction with loneliness was related to slower cognitive decline in semantic memory and better visuospatial performance. Finally, the current study also established that loneliness was a predictor of the incidence of AD and other dementias. The present findings support the growing literature, which tends to show that the consequence of loneliness goes beyond the feeling of being isolated. Loneliness may induce physiological changes in our brains that lead to cognitive decline over time. Future research can explore a wide range of biological and psychological expressions of loneliness to clarify how loneliness relates to dementia.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798379428624Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Alzheimer's diseaseIndex Terms--Genre/Form:

542853
Electronic books.

Neurobiological Mechanisms Involved in the Relationship Between Loneliness, Depression, and Cognitive Decline in Older Adults.
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520 $a Loneliness, among older adults, is one of the risk factors for developing dementia. Still, little is known about the neurobiological and psychological conditions that link loneliness to cognitive decline. The current study was intended to address several research aims: First, it sought to determine whether the relationship between loneliness and cognitive decline is sex-specific in older adults. Second, it sought to identify neurobiological and psychological pathways that may account for the relationship between loneliness and decline across several cognitive domains. These pathways included depressive symptoms, gray and white matter volume, and conditional analyses of pro-inflammatory cytokines and brain-derived neurotrophic factor (BDNF) expression. Third, it examined loneliness as a predictor of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal data were collected from 2130 Rush Memory and Aging ProjectMAP participants. Participants underwent annual cognitive and psychological assessments, as well as neuroimaging procedures every year. BDNF gene expression was measured in the dorsolateral prefrontal cortex, and the final clinical diagnosis was identified upon autopsy at death. Linear mixed models and multinomial logistic regression analyses were used to measure serum samples of pro-inflammatory cytokines All models controlled for age at baseline, education, and sex. Participants were largely women (73%), and Caucasian (93%). The average education was 14.93 (SD=3.34). The average age at baseline was 80.05 (SD=7.57). Results showed that gray matter volume and depressive symptoms partially mediated the relationship between loneliness and cognitive decline. BDNF expression was positively related to cognitive performance, and its interaction with loneliness was related to slower cognitive decline in semantic memory and better visuospatial performance. Finally, the current study also established that loneliness was a predictor of the incidence of AD and other dementias. The present findings support the growing literature, which tends to show that the consequence of loneliness goes beyond the feeling of being isolated. Loneliness may induce physiological changes in our brains that lead to cognitive decline over time. Future research can explore a wide range of biological and psychological expressions of loneliness to clarify how loneliness relates to dementia.
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