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Design of an Accelerated Longitudinal Cohort to Estimate Employment Trajectories Using Multistate Models in a Population of Young Adults with Systemic Lupus Erythematosus.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Design of an Accelerated Longitudinal Cohort to Estimate Employment Trajectories Using Multistate Models in a Population of Young Adults with Systemic Lupus Erythematosus./
Author:	Konstantinidis, Menelaos.
Description:	1 online resource (79 pages)
Notes:	Source: Masters Abstracts International, Volume: 84-05.
Contained By:	Masters Abstracts International84-05.
Subject:	Biostatistics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29396143click for full text (PQDT)
ISBN:	9798357556158

Design of an Accelerated Longitudinal Cohort to Estimate Employment Trajectories Using Multistate Models in a Population of Young Adults with Systemic Lupus Erythematosus.
Konstantinidis, Menelaos.

Design of an Accelerated Longitudinal Cohort to Estimate Employment Trajectories Using Multistate Models in a Population of Young Adults with Systemic Lupus Erythematosus. - 1 online resource (79 pages)

Source: Masters Abstracts International, Volume: 84-05.

Thesis (M.Sc.)--University of Toronto (Canada), 2022.

Includes bibliographical references

Background: Systemic Lupus Erythematosus (SLE) is the most common form of Lupus.Objectives: To design a prospective accelerated longitudinal cohort (ALC) to study the employment trajectory of young-adult SLE patients.Methods: We analyzed a multicentre retrospective cohort of SLE patients using multi-state models to assess risk factors for unfavourable employment trajectories. Additionally, we conducted a simulation study to design an ALC that optimized the precision and bias for the probability of transitioning between employment states.Results: Due to insufficient data, model convergence in the retrospective cohort and simulation study was poor.Conclusions: ALCs are an attractive design for prospective studies; however, it is not an appropriate study design for the present population. For rare diseases such as SLE, the number of transitions is likely to be small. Future work should focus on expanding the objective to include additional populations who would benefit from interventions on undesirable employment trajectories.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798357556158Subjects--Topical Terms:

1002712
Biostatistics.
Subjects--Index Terms:

Accelerated longitudinal designIndex Terms--Genre/Form:

542853
Electronic books.

Design of an Accelerated Longitudinal Cohort to Estimate Employment Trajectories Using Multistate Models in a Population of Young Adults with Systemic Lupus Erythematosus.
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245 1 0 $a Design of an Accelerated Longitudinal Cohort to Estimate Employment Trajectories Using Multistate Models in a Population of Young Adults with Systemic Lupus Erythematosus.
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500 $a Source: Masters Abstracts International, Volume: 84-05.
500 $a Advisor: Pullenayegum, Eleanor M.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2022.
504 $a Includes bibliographical references
520 $a Background: Systemic Lupus Erythematosus (SLE) is the most common form of Lupus.Objectives: To design a prospective accelerated longitudinal cohort (ALC) to study the employment trajectory of young-adult SLE patients.Methods: We analyzed a multicentre retrospective cohort of SLE patients using multi-state models to assess risk factors for unfavourable employment trajectories. Additionally, we conducted a simulation study to design an ALC that optimized the precision and bias for the probability of transitioning between employment states.Results: Due to insufficient data, model convergence in the retrospective cohort and simulation study was poor.Conclusions: ALCs are an attractive design for prospective studies; however, it is not an appropriate study design for the present population. For rare diseases such as SLE, the number of transitions is likely to be small. Future work should focus on expanding the objective to include additional populations who would benefit from interventions on undesirable employment trajectories.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Biostatistics. $3 1002712
653 $a Accelerated longitudinal design
653 $a Employment trajectory
653 $a Experimental design
653 $a Multi state model
653 $a Simulation
653 $a Systemic lupus erythematosus
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773 0 $t Masters Abstracts International $g 84-05.
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