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The nature of the resistance to steroid hypertension in Wistar-Furth rats.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The nature of the resistance to steroid hypertension in Wistar-Furth rats./
作者:	Chen, Jiann-Torng.
面頁冊數:	1 online resource (191 pages)
附註:	Source: Dissertations Abstracts International, Volume: 60-01, Section: B.
Contained By:	Dissertations Abstracts International60-01B.
標題:	Pathology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9822116click for full text (PQDT)
ISBN:	9780591739312

The nature of the resistance to steroid hypertension in Wistar-Furth rats.
Chen, Jiann-Torng.

The nature of the resistance to steroid hypertension in Wistar-Furth rats. - 1 online resource (191 pages)

Source: Dissertations Abstracts International, Volume: 60-01, Section: B.

Thesis (Ph.D.)--State University of New York at Buffalo, 1998.

Includes bibliographical references

The nature of the resistance of the Wistar-Furth (W/Fu) rat strain to steroid hypertension was investigated. The basal levels of renal kallikrein mRNA and kallikrein activity measured in intact or uninephrectomized animals were higher in W/Fu than in WI rats. The induction of renal kallikrein mRNA in response to DOCA treatment was similar in both strains. However, renal kallikrein activity increased progressively in W/Fu rats and declined in WI rats. Both urinary total and active kallikrein activities were higher in DOCA-treated W/Fu rats than in the similarly treated WI rats. Co-administration of DOCA and Hoe 140, a bradykinin type 2 receptor antagonist, raised the blood pressure of W/Fu rats into the hypertensive range. Furthermore, with this regimen W/Fu rats developed hypernatremia. These findings suggest that bradykinin (a product of kallikrein action) plays an important role in the resistance of W/Fu rats to mineralocorticoid hypertension. Collectively, these results suggest that W/Fu rats have a more active renal kallikrein-kinin system. Co-administration of Hoe 140 modestly, but significantly, enhanced the blood pressure response to dexamethasone (a synthetic glucocorticoid) in W/Fu rats but not in similarly treated WI rats. This suggests that bradykinin and the kallikrein-kinin system have a very modest role in counteracting the hypertensive effect of glucocorticoid, in general, and in the W/Fu rat strain in particular.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9780591739312Subjects--Topical Terms:

643180
Pathology.
Subjects--Index Terms:

kallikrein activityIndex Terms--Genre/Form:

542853
Electronic books.

The nature of the resistance to steroid hypertension in Wistar-Furth rats.
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504 $a Includes bibliographical references
520 $a The nature of the resistance of the Wistar-Furth (W/Fu) rat strain to steroid hypertension was investigated. The basal levels of renal kallikrein mRNA and kallikrein activity measured in intact or uninephrectomized animals were higher in W/Fu than in WI rats. The induction of renal kallikrein mRNA in response to DOCA treatment was similar in both strains. However, renal kallikrein activity increased progressively in W/Fu rats and declined in WI rats. Both urinary total and active kallikrein activities were higher in DOCA-treated W/Fu rats than in the similarly treated WI rats. Co-administration of DOCA and Hoe 140, a bradykinin type 2 receptor antagonist, raised the blood pressure of W/Fu rats into the hypertensive range. Furthermore, with this regimen W/Fu rats developed hypernatremia. These findings suggest that bradykinin (a product of kallikrein action) plays an important role in the resistance of W/Fu rats to mineralocorticoid hypertension. Collectively, these results suggest that W/Fu rats have a more active renal kallikrein-kinin system. Co-administration of Hoe 140 modestly, but significantly, enhanced the blood pressure response to dexamethasone (a synthetic glucocorticoid) in W/Fu rats but not in similarly treated WI rats. This suggests that bradykinin and the kallikrein-kinin system have a very modest role in counteracting the hypertensive effect of glucocorticoid, in general, and in the W/Fu rat strain in particular.
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