東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

FindBook

Google Book

Amazon

博客來

The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations./
作者:	Peralta-Neel, Zulema M.
面頁冊數:	1 online resource (504 pages)
附註:	Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
Contained By:	Dissertations Abstracts International85-01B.
標題:	Organic chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29394942click for full text (PQDT)
ISBN:	9798379776244

The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations.
Peralta-Neel, Zulema M.

The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations. - 1 online resource (504 pages)

Source: Dissertations Abstracts International, Volume: 85-01, Section: B.

Thesis (Ph.D.)--New York University, 2023.

Includes bibliographical references

Endoperoxide motifs can be found in a plethora of natural products and have demonstrated toxicity to a number of cancer cell lines. The synthesis of these endoperoxides usually requires the formation of a hydroperoxide or a silylperoxide. The hydroperoxide is then deprotonated using a base, and an intramolecular Michael addition leads to formation of the cyclic core. Chapter One of this thesis will discuss our attempts at finding a new catalyst that could lead to hydroperoxidations in high yields. The catalyst we discovered, Co(pic)2, has demonstrated different reactivity than the cobalt 1,3-diketonate complexes that are used to form silylperoxides. Chapter Two presents two new ways to form 1,2-dioxolanes or 1,2-dioxanes by suggesting the formation of a substrate that could inhibit the major path of decomposition seen in base-promoted oxa-Michael additions, and proposes using a Semmelhack-like reaction to form endoperoxide cores in one step. Chapter Three expands on cobalt picolinate complexes and how they can be used to oxidize alkynes into 1,2-diketones or methyl ketones depending on the substrate used. Chapter Four describes our continued work on base-promoted cyclizations to form endoperoxides, this time with a focus on the formation of aromatic peroxides, which have been notoriously difficult to isolate in a laboratory setting.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798379776244Subjects--Topical Terms:

523952
Organic chemistry.
Subjects--Index Terms:

Cobalt picolinateIndex Terms--Genre/Form:

542853
Electronic books.

The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations.
LDR:02624nmm a2200361K 4500 001 2363464
005 20231127093410.5
006 m o d
007 cr mn ---uuuuu
008 241011s2023 xx obm 000 0 eng d
020 $a 9798379776244
035 $a (MiAaPQ)AAI29394942
035 $a AAI29394942
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Peralta-Neel, Zulema M. $3 3704225
245 1 4 $a The Use of Cobalt Picolinate in Hydroperoxidations and Oxidations.
264 0 $c 2023
300 $a 1 online resource (504 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 85-01, Section: B.
500 $a Advisor: Woerpel, Keith.
502 $a Thesis (Ph.D.)--New York University, 2023.
504 $a Includes bibliographical references
520 $a Endoperoxide motifs can be found in a plethora of natural products and have demonstrated toxicity to a number of cancer cell lines. The synthesis of these endoperoxides usually requires the formation of a hydroperoxide or a silylperoxide. The hydroperoxide is then deprotonated using a base, and an intramolecular Michael addition leads to formation of the cyclic core. Chapter One of this thesis will discuss our attempts at finding a new catalyst that could lead to hydroperoxidations in high yields. The catalyst we discovered, Co(pic)2, has demonstrated different reactivity than the cobalt 1,3-diketonate complexes that are used to form silylperoxides. Chapter Two presents two new ways to form 1,2-dioxolanes or 1,2-dioxanes by suggesting the formation of a substrate that could inhibit the major path of decomposition seen in base-promoted oxa-Michael additions, and proposes using a Semmelhack-like reaction to form endoperoxide cores in one step. Chapter Three expands on cobalt picolinate complexes and how they can be used to oxidize alkynes into 1,2-diketones or methyl ketones depending on the substrate used. Chapter Four describes our continued work on base-promoted cyclizations to form endoperoxides, this time with a focus on the formation of aromatic peroxides, which have been notoriously difficult to isolate in a laboratory setting.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Organic chemistry. $3 523952
650 4 $a Chemistry. $3 516420
653 $a Cobalt picolinate
653 $a Endoperoxides
653 $a Hydroperoxides
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0490
690 $a 0485
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a New York University. $b Chemistry. $3 1064483
773 0 $t Dissertations Abstracts International $g 85-01B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29394942 $z click for full text (PQDT)