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High Resolution 3D Mapping of the Oxytocin System Across Time and Space in the Mouse Brain.

Record Type:	Electronic resources : Monograph/item
Title/Author:	High Resolution 3D Mapping of the Oxytocin System Across Time and Space in the Mouse Brain./
Author:	Newmaster, Kyra T.
Description:	1 online resource (222 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-02, Section: B.
Contained By:	Dissertations Abstracts International84-02B.
Subject:	Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29276510click for full text (PQDT)
ISBN:	9798841572398

High Resolution 3D Mapping of the Oxytocin System Across Time and Space in the Mouse Brain.
Newmaster, Kyra T.

High Resolution 3D Mapping of the Oxytocin System Across Time and Space in the Mouse Brain. - 1 online resource (222 pages)

Source: Dissertations Abstracts International, Volume: 84-02, Section: B.

Thesis (Ph.D.)--The Pennsylvania State University, 2022.

Includes bibliographical references

Oxytocin (OT) is a neurohormone that is predominantly secreted by neurons in the paraventricular hypothalamus (PVH) and is classically associated with sociosexual and parenting behavior. Because acute application of OT produces increased interest in social cues, OT and its cognate receptor, oxytocin receptor (OTR), have been widely studied to develop potential therapies for neurodevelopmental disorders and/or social deficits. However, OT is able to regulate a diverse set of functions outside of social behavior in part OT projections and OTR have widespread patterns in the brain. Because this system is distributed across many disparate anatomical and functional categories, it has been difficult to develop a quantitative profile of OTR/OT, but this profile is the key to understanding how this neuromodulator coordinates different neural processes and predicting behavioral outcomes of changes to OTR/OT signaling. The following work uses whole brain cellular resolution brain mapping to quantify OT projections, OTR expressing cells, cellular activity across space and time in the mouse brain. Whole brain mapping is a technique that combines different cell-type labelling methods with high resolution volumetric microcopy and computational signal quantification. We created age specific templates for postnatal mouse brains to map developmental OTR dynamics and revealed specific cortical and subcortical patterns indicating that developmental OTR signaling can coordinate neural circuit maturation. We also develop a new pipeline to quantify neural activity in light sheet images and compare animals with and without OTR to show changes in processing sensory information. Finally, we use brain mapping pipeline to map all the adult OTR and OT signals into a single standard reference frame and showed that the OTR/OT system has two anatomically distinct subsystems that imply the presence of both fast and slow regulation. Together these brain maps highlight how the OT/OTR system is able to control many functions while also showing the power and promise of the current and future brain mapping technology.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798841572398Subjects--Topical Terms:

518431
Physiology.
Index Terms--Genre/Form:

542853
Electronic books.

High Resolution 3D Mapping of the Oxytocin System Across Time and Space in the Mouse Brain.
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504 $a Includes bibliographical references
520 $a Oxytocin (OT) is a neurohormone that is predominantly secreted by neurons in the paraventricular hypothalamus (PVH) and is classically associated with sociosexual and parenting behavior. Because acute application of OT produces increased interest in social cues, OT and its cognate receptor, oxytocin receptor (OTR), have been widely studied to develop potential therapies for neurodevelopmental disorders and/or social deficits. However, OT is able to regulate a diverse set of functions outside of social behavior in part OT projections and OTR have widespread patterns in the brain. Because this system is distributed across many disparate anatomical and functional categories, it has been difficult to develop a quantitative profile of OTR/OT, but this profile is the key to understanding how this neuromodulator coordinates different neural processes and predicting behavioral outcomes of changes to OTR/OT signaling. The following work uses whole brain cellular resolution brain mapping to quantify OT projections, OTR expressing cells, cellular activity across space and time in the mouse brain. Whole brain mapping is a technique that combines different cell-type labelling methods with high resolution volumetric microcopy and computational signal quantification. We created age specific templates for postnatal mouse brains to map developmental OTR dynamics and revealed specific cortical and subcortical patterns indicating that developmental OTR signaling can coordinate neural circuit maturation. We also develop a new pipeline to quantify neural activity in light sheet images and compare animals with and without OTR to show changes in processing sensory information. Finally, we use brain mapping pipeline to map all the adult OTR and OT signals into a single standard reference frame and showed that the OTR/OT system has two anatomically distinct subsystems that imply the presence of both fast and slow regulation. Together these brain maps highlight how the OT/OTR system is able to control many functions while also showing the power and promise of the current and future brain mapping technology.
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