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Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway./
Author:	Ritchie, Christopher.
Description:	1 online resource (131 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
Contained By:	Dissertations Abstracts International84-12B.
Subject:	Infections. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30482722click for full text (PQDT)
ISBN:	9798379657185

Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway.
Ritchie, Christopher.

Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway. - 1 online resource (131 pages)

Source: Dissertations Abstracts International, Volume: 84-12, Section: B.

Thesis (Ph.D.)--Stanford University, 2023.

Includes bibliographical references

Throughout our lifetimes, our bodies encounter a plethora of threats on the cellular level, including pathogen infection, cellular damage, and the development of cancer. When these threats are not properly detected, they can lead to serious health problems, including death. Thankfully, our cells are pre-programmed with an array of innate immune pathways that can quickly respond to threats by detecting specific molecular danger signals that indicate a threat is present. Of these innate immune pathways, the cGAMP-STING pathway is on the forefront of the immune response due to its ability to detect mislocalized double stranded DNA (dsDNA). Since mislocalized dsDNA is a danger signal nearly ubiquitous with cellular threats, the cGAMP-STING pathway is essential for responding to most threats, including pathogen infection, cellular damage, and cancer. Given the extensive role of the cGAMP-STING pathway in defending against threats, regulation of the pathway is crucial to ensure its proper function. In this work, I show how intercellular pathway activation is regulated through cell-type specific transporters of the pathway's agonist, cGAMP, and how intracellular pathway activation is regulated through the E3-ubiquitin ligase PELI2.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798379657185Subjects--Topical Terms:

1621997
Infections.
Index Terms--Genre/Form:

542853
Electronic books.

Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway.
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245 1 0 $a Regulatory Mechanisms of the Anti-cancer Cgamp-sting Pathway.
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300 $a 1 online resource (131 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 84-12, Section: B.
500 $a Advisor: Gao, Alex;Kim, Peter;Li, Lingyin.
502 $a Thesis (Ph.D.)--Stanford University, 2023.
504 $a Includes bibliographical references
520 $a Throughout our lifetimes, our bodies encounter a plethora of threats on the cellular level, including pathogen infection, cellular damage, and the development of cancer. When these threats are not properly detected, they can lead to serious health problems, including death. Thankfully, our cells are pre-programmed with an array of innate immune pathways that can quickly respond to threats by detecting specific molecular danger signals that indicate a threat is present. Of these innate immune pathways, the cGAMP-STING pathway is on the forefront of the immune response due to its ability to detect mislocalized double stranded DNA (dsDNA). Since mislocalized dsDNA is a danger signal nearly ubiquitous with cellular threats, the cGAMP-STING pathway is essential for responding to most threats, including pathogen infection, cellular damage, and cancer. Given the extensive role of the cGAMP-STING pathway in defending against threats, regulation of the pathway is crucial to ensure its proper function. In this work, I show how intercellular pathway activation is regulated through cell-type specific transporters of the pathway's agonist, cGAMP, and how intracellular pathway activation is regulated through the E3-ubiquitin ligase PELI2.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Infections. $3 1621997
650 4 $a Cancer. $3 634186
650 4 $a Endoplasmic reticulum. $3 663051
650 4 $a Biochemistry. $3 518028
650 4 $a Polymerization. $3 560492
650 4 $a Binding sites. $3 3560349
650 4 $a Cytokines. $3 687114
650 4 $a Autophagy. $3 2045493
650 4 $a Genes. $3 600676
650 4 $a Apoptosis. $3 600650
650 4 $a Cell cycle. $3 766119
650 4 $a Polymers. $3 535398
650 4 $a Dendritic cells. $3 1001571
650 4 $a Regulation. $3 3561775
650 4 $a Bacterial infections. $3 3559961
650 4 $a Lymphocytes. $3 895384
650 4 $a Antigens. $3 700737
650 4 $a Phosphorylation. $3 816803
650 4 $a Viral infections. $3 3540521
650 4 $a Enzymes. $3 520899
650 4 $a Interferon. $3 671927
650 4 $a Transcription factors. $3 669191
650 4 $a Cellular biology. $3 3172791
650 4 $a Immunology. $3 611031
650 4 $a Pathology. $3 643180
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Polymer chemistry. $3 3173488
650 4 $a Virology. $3 642304
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0487
690 $a 0379
690 $a 0982
690 $a 0571
690 $a 0572
690 $a 0495
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710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a Stanford University. $3 754827
773 0 $t Dissertations Abstracts International $g 84-12B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30482722 $z click for full text (PQDT)