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Biomaterials for Application as Bio-Interface.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Biomaterials for Application as Bio-Interface./
Author:	Yang, Kai-Hung.
Description:	1 online resource (265 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-02, Section: B.
Contained By:	Dissertations Abstracts International84-02B.
Subject:	Tissue engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29228695click for full text (PQDT)
ISBN:	9798841531456

Biomaterials for Application as Bio-Interface.
Yang, Kai-Hung.

Biomaterials for Application as Bio-Interface. - 1 online resource (265 pages)

Source: Dissertations Abstracts International, Volume: 84-02, Section: B.

Thesis (Ph.D.)--North Carolina State University, 2022.

Includes bibliographical references

Biomaterial can be defined as any substance that has been engineered to interact with biological system to probe or restore the function of our body. In recent year, efforts have been made to develop biomaterials for implants, wound dressing, regenerative medical treatment and electrodes trying to improve the life for living creature. This spans a wide range of materials from very hard materials, such as carbon-based materials, to extremely soft material such as hydrogel. The difference in young's modulus can be over 7 orders of magnitude. Several unmet needs have been reported toward regeneration of the function. Therefore, the first goal of this work was to investigate the use of gelatin methacryloyl (GelMA) and allylated gelatin (GelAGE) as a 3D scaffold for cellular growth aiming for recapitulating the structure−function relationships similar to native tissues toward the fabrication of replacements for the organ/tissue. Although gelatin-based hydrogel has been extensively studied in the past few years, a more efficient photoinitiator is still in demand. In this work, novel photoinitiators with visible-light absorptivity and water solubility were evaluated for efficient photocrosslinking which circumvent the UVinduced genotoxicity while widening the window of exposure condition. Ruthenium / sodium persulfate (Ru/SPS) exhibited strong absorption in visible-light range while the concurrent redox crosslinking enable the tailoring of viscosity and more depth of cure. The water-soluble diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide (TPO) nanoparticle could be used without the introduce of lithium. However, the use of surfactant should be optimized toward substantial biocompatibility.As neurological disorder or damage could result in a permanent loss of function, the restoration of function with the use of biocompatible and robust electrodes for neural stimulation and therapy was of great interest. Thus, the second goal of this work was to evaluate the feasibility of applying nitrogen-incorporated ultrananocrystalline diamond (N-UNCD) as bio-interface and the use of this carbon-based coatings for neural stimulation. The geometry of the coating, including solid surface, nano-porous membrane and graphene induced microelectrodes, were evaluated with cellular adhesion. The surface composition, bonding character, wettability, charge and roughness were evaluated and correlated with electrochemical properties as well as biological response. The results demonstrated the capability of applying N-UNCD and hybrid (N-UNCD + graphene) coatings as material for neural stimulation is comparable with commonly used materials. No inhibitive effect on cell viability, mitochondrial function and neural outgrowth was evident suggesting the potential of using these coatings as electrodes for neural stimulation with tunable surface properties. Additionally, the use of another category of carbon-based material, diamond-like carbon (DLC), with oxygen plasma treatment exhibited a significant antifungal behavior which demonstrated the potential use of this material as coatings for biomedical implants.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798841531456Subjects--Topical Terms:

823582
Tissue engineering.
Index Terms--Genre/Form:

542853
Electronic books.

Biomaterials for Application as Bio-Interface.
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500 $a Source: Dissertations Abstracts International, Volume: 84-02, Section: B.
500 $a Advisor: Narayan, Roger.
502 $a Thesis (Ph.D.)--North Carolina State University, 2022.
504 $a Includes bibliographical references
520 $a Biomaterial can be defined as any substance that has been engineered to interact with biological system to probe or restore the function of our body. In recent year, efforts have been made to develop biomaterials for implants, wound dressing, regenerative medical treatment and electrodes trying to improve the life for living creature. This spans a wide range of materials from very hard materials, such as carbon-based materials, to extremely soft material such as hydrogel. The difference in young's modulus can be over 7 orders of magnitude. Several unmet needs have been reported toward regeneration of the function. Therefore, the first goal of this work was to investigate the use of gelatin methacryloyl (GelMA) and allylated gelatin (GelAGE) as a 3D scaffold for cellular growth aiming for recapitulating the structure−function relationships similar to native tissues toward the fabrication of replacements for the organ/tissue. Although gelatin-based hydrogel has been extensively studied in the past few years, a more efficient photoinitiator is still in demand. In this work, novel photoinitiators with visible-light absorptivity and water solubility were evaluated for efficient photocrosslinking which circumvent the UVinduced genotoxicity while widening the window of exposure condition. Ruthenium / sodium persulfate (Ru/SPS) exhibited strong absorption in visible-light range while the concurrent redox crosslinking enable the tailoring of viscosity and more depth of cure. The water-soluble diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide (TPO) nanoparticle could be used without the introduce of lithium. However, the use of surfactant should be optimized toward substantial biocompatibility.As neurological disorder or damage could result in a permanent loss of function, the restoration of function with the use of biocompatible and robust electrodes for neural stimulation and therapy was of great interest. Thus, the second goal of this work was to evaluate the feasibility of applying nitrogen-incorporated ultrananocrystalline diamond (N-UNCD) as bio-interface and the use of this carbon-based coatings for neural stimulation. The geometry of the coating, including solid surface, nano-porous membrane and graphene induced microelectrodes, were evaluated with cellular adhesion. The surface composition, bonding character, wettability, charge and roughness were evaluated and correlated with electrochemical properties as well as biological response. The results demonstrated the capability of applying N-UNCD and hybrid (N-UNCD + graphene) coatings as material for neural stimulation is comparable with commonly used materials. No inhibitive effect on cell viability, mitochondrial function and neural outgrowth was evident suggesting the potential of using these coatings as electrodes for neural stimulation with tunable surface properties. Additionally, the use of another category of carbon-based material, diamond-like carbon (DLC), with oxygen plasma treatment exhibited a significant antifungal behavior which demonstrated the potential use of this material as coatings for biomedical implants.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
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