東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

FindBook

Google Book

Amazon

博客來

The Early Life Environment and Adult Cognitive and Mental Health.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Early Life Environment and Adult Cognitive and Mental Health./
作者:	Reuben, Aaron.
面頁冊數:	1 online resource (180 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-03, Section: B.
Contained By:	Dissertations Abstracts International84-03B.
標題:	Psychology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28315053click for full text (PQDT)
ISBN:	9798351450278

The Early Life Environment and Adult Cognitive and Mental Health.
Reuben, Aaron.

The Early Life Environment and Adult Cognitive and Mental Health. - 1 online resource (180 pages)

Source: Dissertations Abstracts International, Volume: 84-03, Section: B.

Thesis (Ph.D.)--Duke University, 2023.

Includes bibliographical references

Many diverse adult diseases, from diabetes to dementia, are increasingly viewed as arising, in part, from early life environmental influences. The so-called Developmental Origins of Health and Disease (DOHaD) research paradigm offers the potential to improve our understanding of the etiology of many hard-to-treat adult diseases by focusing researcher's attention on the pre and post-natal and early childhood years, where small interventions could pay large dividends later on. Along with great potential, the DOHaD framework offers great challenges, as it is logistically and conceptually difficult to investigate the environmental origins of chronic diseases that may manifest only decades after harmful exposures.This dissertation presents a series of five original studies that sought to answer open empirical questions about the developmental origins of health and disease focusing on early-life factors that influence the health and aging of the brain. Three increasingly broad "levels" of the early life environment are considered across three sequential dissertation chapters: (1) the individual micro-physical level, (2) the family level, and (3) the neighborhood level. At each level this dissertation considers at least one exposure that has relevance to researchers and policy makers, either because, like exposure to neighborhood vegetation / greenery, it may offer a good route for intervention (e.g., the exposure is potentially modifiable) or because, like exposure to the heavy metal lead, it is understood to be more widespread than previously assumed. Studies were conducted using data from two population-representative longitudinal birth cohorts, the New Zealand-based Dunedin Multidisciplinary Health and Development Study (born in 1972-1973) and the United Kingdom-based Environmental Risk Longitudinal Twin Study (born in 1994-1995).Across the five studies, results supported the DOHaD framework and provided new evidence about the long-term consequences of childhood exposure to lead, adversity (e.g., physical and emotional abuse, household dysfunction, etc.), and neighborhood disadvantage. These negative early life events / exposures at the micro-physical, family, and neighborhood-levels associated, across multiple decades, with subtle and diverse poor brain-related outcomes later in life, including diminished cognitive capacity, increased symptoms of psychopathology, altered epigenetic controls, disadvantageous personality styles, and worse physical health. Results collectively reinforce the view that the early life represents a profound window of vulnerability and opportunity, with a lifespan perspective offering great potential for more efficacious public health research, clinical practice, and policy, as the diseases of the adult likely have roots in the life of the child.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798351450278Subjects--Topical Terms:

519075
Psychology.
Subjects--Index Terms:

AdultIndex Terms--Genre/Form:

542853
Electronic books.

The Early Life Environment and Adult Cognitive and Mental Health.
LDR:04240nmm a2200409K 4500 001 2361748
005 20231027102258.5
006 m o d
007 cr mn ---uuuuu
008 241011s2023 xx obm 000 0 eng d
020 $a 9798351450278
035 $a (MiAaPQ)AAI28315053
035 $a AAI28315053
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Reuben, Aaron. $3 3702433
245 1 4 $a The Early Life Environment and Adult Cognitive and Mental Health.
264 0 $c 2023
300 $a 1 online resource (180 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 84-03, Section: B.
500 $a Includes supplementary digital materials.
500 $a Advisor: Moffitt, Terrie E.
502 $a Thesis (Ph.D.)--Duke University, 2023.
504 $a Includes bibliographical references
520 $a Many diverse adult diseases, from diabetes to dementia, are increasingly viewed as arising, in part, from early life environmental influences. The so-called Developmental Origins of Health and Disease (DOHaD) research paradigm offers the potential to improve our understanding of the etiology of many hard-to-treat adult diseases by focusing researcher's attention on the pre and post-natal and early childhood years, where small interventions could pay large dividends later on. Along with great potential, the DOHaD framework offers great challenges, as it is logistically and conceptually difficult to investigate the environmental origins of chronic diseases that may manifest only decades after harmful exposures.This dissertation presents a series of five original studies that sought to answer open empirical questions about the developmental origins of health and disease focusing on early-life factors that influence the health and aging of the brain. Three increasingly broad "levels" of the early life environment are considered across three sequential dissertation chapters: (1) the individual micro-physical level, (2) the family level, and (3) the neighborhood level. At each level this dissertation considers at least one exposure that has relevance to researchers and policy makers, either because, like exposure to neighborhood vegetation / greenery, it may offer a good route for intervention (e.g., the exposure is potentially modifiable) or because, like exposure to the heavy metal lead, it is understood to be more widespread than previously assumed. Studies were conducted using data from two population-representative longitudinal birth cohorts, the New Zealand-based Dunedin Multidisciplinary Health and Development Study (born in 1972-1973) and the United Kingdom-based Environmental Risk Longitudinal Twin Study (born in 1994-1995).Across the five studies, results supported the DOHaD framework and provided new evidence about the long-term consequences of childhood exposure to lead, adversity (e.g., physical and emotional abuse, household dysfunction, etc.), and neighborhood disadvantage. These negative early life events / exposures at the micro-physical, family, and neighborhood-levels associated, across multiple decades, with subtle and diverse poor brain-related outcomes later in life, including diminished cognitive capacity, increased symptoms of psychopathology, altered epigenetic controls, disadvantageous personality styles, and worse physical health. Results collectively reinforce the view that the early life represents a profound window of vulnerability and opportunity, with a lifespan perspective offering great potential for more efficacious public health research, clinical practice, and policy, as the diseases of the adult likely have roots in the life of the child.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Psychology. $3 519075
650 4 $a Neurosciences. $3 588700
650 4 $a Environmental health. $3 543032
653 $a Adult
653 $a Child
653 $a Cognitive decline
653 $a Developmental origins of health and disease
653 $a Mental health
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0621
690 $a 0317
690 $a 0470
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a Duke University. $b Psychology and Neuroscience. $3 1669187
773 0 $t Dissertations Abstracts International $g 84-03B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28315053 $z click for full text (PQDT)