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Investigating the Role of the Hippocampus in Remote Memory Retrieval.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Investigating the Role of the Hippocampus in Remote Memory Retrieval./
Author:	Hamidi, Anahita Bahiyyih.
Description:	1 online resource (90 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 79-06, Section: B.
Contained By:	Dissertations Abstracts International79-06B.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10621809click for full text (PQDT)
ISBN:	9780355461749

Investigating the Role of the Hippocampus in Remote Memory Retrieval.
Hamidi, Anahita Bahiyyih.

Investigating the Role of the Hippocampus in Remote Memory Retrieval. - 1 online resource (90 pages)

Source: Dissertations Abstracts International, Volume: 79-06, Section: B.

Thesis (Ph.D.)--University of California, Davis, 2017.

Includes bibliographical references

According to the theory of systems consolidation, the brain circuits required to successfully retrieve a memory depend on the age of the memory itself (Squire, 1992; Squire and Alvarez, 1995). Specifically, the theory claims that newer (recent) memories are hippocampal dependent while older (remote) memories are hippocampal independent. Our group recently provided direct evidence (Tanaka et al., 2014) that reactivation of a specific ensemble of hippocampal neurons is necessary for the successful retrieval of a recent (2-day) memory. In the present study, I aimed to silence a specific hippocampal ensemble (i.e. selectively silence) at a remote (14-day) time point using both optogenetic (Chapter 2) and pharmacological (Chapter 3) methods. The optogenetic silencing condition impaired remote memory retrieval, whereas the pharmacological manipulation did not. However, imaging of brain tissue revealed that the optogenetic manipulation resulted in non-selective silencing. Thus, I performed follow-up experiments to test first, whether altering the doxycycline dosage could rescue the non- selective silencing (Chapter 4.1) and second, whether I could replicate the findings of others who have done prolonged, non-selective hippocampal silencing (Chapter 4.2).

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9780355461749Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

HippocampusIndex Terms--Genre/Form:

542853
Electronic books.

Investigating the Role of the Hippocampus in Remote Memory Retrieval.
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500 $a Source: Dissertations Abstracts International, Volume: 79-06, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Ekstrom, Arne.
502 $a Thesis (Ph.D.)--University of California, Davis, 2017.
504 $a Includes bibliographical references
520 $a According to the theory of systems consolidation, the brain circuits required to successfully retrieve a memory depend on the age of the memory itself (Squire, 1992; Squire and Alvarez, 1995). Specifically, the theory claims that newer (recent) memories are hippocampal dependent while older (remote) memories are hippocampal independent. Our group recently provided direct evidence (Tanaka et al., 2014) that reactivation of a specific ensemble of hippocampal neurons is necessary for the successful retrieval of a recent (2-day) memory. In the present study, I aimed to silence a specific hippocampal ensemble (i.e. selectively silence) at a remote (14-day) time point using both optogenetic (Chapter 2) and pharmacological (Chapter 3) methods. The optogenetic silencing condition impaired remote memory retrieval, whereas the pharmacological manipulation did not. However, imaging of brain tissue revealed that the optogenetic manipulation resulted in non-selective silencing. Thus, I performed follow-up experiments to test first, whether altering the doxycycline dosage could rescue the non- selective silencing (Chapter 4.1) and second, whether I could replicate the findings of others who have done prolonged, non-selective hippocampal silencing (Chapter 4.2).
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
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650 4 $a Psychobiology. $3 555678
650 4 $a Behavioral psychology. $3 2122788
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653 $a Optogenetics
653 $a Retrieval
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773 0 $t Dissertations Abstracts International $g 79-06B.
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