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Effects of grain sorghum wax and oil on cholesterol levels, gut microbiota, and tissue metabolic fingerprints / profiles of a hamster model with diet-induced hypercholesterolemia.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Effects of grain sorghum wax and oil on cholesterol levels, gut microbiota, and tissue metabolic fingerprints / profiles of a hamster model with diet-induced hypercholesterolemia./
作者:	Lee, Bo Hyun.
面頁冊數:	1 online resource (147 pages)
附註:	Source: Dissertations Abstracts International, Volume: 74-07, Section: B.
Contained By:	Dissertations Abstracts International74-07B.
標題:	Food science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3547571click for full text (PQDT)
ISBN:	9781267823380

Effects of grain sorghum wax and oil on cholesterol levels, gut microbiota, and tissue metabolic fingerprints / profiles of a hamster model with diet-induced hypercholesterolemia.
Lee, Bo Hyun.

Effects of grain sorghum wax and oil on cholesterol levels, gut microbiota, and tissue metabolic fingerprints / profiles of a hamster model with diet-induced hypercholesterolemia. - 1 online resource (147 pages)

Source: Dissertations Abstracts International, Volume: 74-07, Section: B.

Thesis (Ph.D.)--The University of Nebraska - Lincoln, 2013.

Includes bibliographical references

Grain sorghum (GS) lipid has shown its ability to positively modulate plasma, hepatic cholesterol and gut microbiota in a hamster model. Responsible lipid ingredients as well as their target and off-target effects on cellular metabolism have not yet been studied as a potential safe and efficacious source of nutraceuticals. In our study, crude GS lipid was fractionated into wax and oil; and male Syrian hamsters were fed either a control diet, an atherogenic (athero) diet, or an athero diet containing 5% GS wax or oil. The objective of this research was to determine the chemical composition of each fraction and to monitor changes in cholesterol profiles, gut microbiota, and metabolic pool of the liver and large intestine of hamsters in response to the diets. The phytosterol rich GS oil showed greater cholesterol lowering impact than did the policosanol rich wax fraction by reducing cholesterol levels and increasing fecal sterol excretion. The wax supplement only increased fecal sterol and bile acid excretion. The athero diet decreased the population of family Lactobacillaceae and genus Lactobacillus in the fecal microbiota. Although GS wax slightly increased the abundance of unclassified Lactobacillaceae, neither GS oil nor wax restored the number of Lactobacillaceae and Lactobacillus. Non-targeted metabolomics using direct infusion mass spectrometry followed by clustering analysis showed GS wax or oil supplement compensated metabolic changes in the large intestine induced by the athero diet, but not in the liver. Targeted profiling of metabolites related to central carbon metabolism showed that the athero diet tended to decrease glycolytic intermediate levels but increase tricarboxylic acid (TCA) cycle intermediates both in the liver and the large intestine. GS oil or wax supplement restored, in part, the glycolysis and TCA cycle intermediates back to the control level, with the oil and the wax having a greater impact on the liver metabolites and the large intestinal metabolites, respectively. Synergistic interplay of various compounds in GS lipids can be proposed based on different metabolic impacts of GS wax and oil, in combination with differences between complex GS lipids and fractionated GS lipids on their ability to modulate cholesterol and gut microbiota.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9781267823380Subjects--Topical Terms:

3173303
Food science.
Subjects--Index Terms:

CholesterolIndex Terms--Genre/Form:

542853
Electronic books.

Effects of grain sorghum wax and oil on cholesterol levels, gut microbiota, and tissue metabolic fingerprints / profiles of a hamster model with diet-induced hypercholesterolemia.
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500 $a Publisher info.: Dissertation/Thesis.
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502 $a Thesis (Ph.D.)--The University of Nebraska - Lincoln, 2013.
504 $a Includes bibliographical references
520 $a Grain sorghum (GS) lipid has shown its ability to positively modulate plasma, hepatic cholesterol and gut microbiota in a hamster model. Responsible lipid ingredients as well as their target and off-target effects on cellular metabolism have not yet been studied as a potential safe and efficacious source of nutraceuticals. In our study, crude GS lipid was fractionated into wax and oil; and male Syrian hamsters were fed either a control diet, an atherogenic (athero) diet, or an athero diet containing 5% GS wax or oil. The objective of this research was to determine the chemical composition of each fraction and to monitor changes in cholesterol profiles, gut microbiota, and metabolic pool of the liver and large intestine of hamsters in response to the diets. The phytosterol rich GS oil showed greater cholesterol lowering impact than did the policosanol rich wax fraction by reducing cholesterol levels and increasing fecal sterol excretion. The wax supplement only increased fecal sterol and bile acid excretion. The athero diet decreased the population of family Lactobacillaceae and genus Lactobacillus in the fecal microbiota. Although GS wax slightly increased the abundance of unclassified Lactobacillaceae, neither GS oil nor wax restored the number of Lactobacillaceae and Lactobacillus. Non-targeted metabolomics using direct infusion mass spectrometry followed by clustering analysis showed GS wax or oil supplement compensated metabolic changes in the large intestine induced by the athero diet, but not in the liver. Targeted profiling of metabolites related to central carbon metabolism showed that the athero diet tended to decrease glycolytic intermediate levels but increase tricarboxylic acid (TCA) cycle intermediates both in the liver and the large intestine. GS oil or wax supplement restored, in part, the glycolysis and TCA cycle intermediates back to the control level, with the oil and the wax having a greater impact on the liver metabolites and the large intestinal metabolites, respectively. Synergistic interplay of various compounds in GS lipids can be proposed based on different metabolic impacts of GS wax and oil, in combination with differences between complex GS lipids and fractionated GS lipids on their ability to modulate cholesterol and gut microbiota.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
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653 $a Cholesterol
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653 $a Gut microbiota
653 $a Hypercholesterolemia
653 $a Oil
653 $a Tissue metabolic fingerprints
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