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Microscopic models for the structure and permeability of the stratum corneum barrier layer of skin.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Microscopic models for the structure and permeability of the stratum corneum barrier layer of skin./
作者:	Wang, Tsuo-Feng.
面頁冊數:	1 online resource (243 pages)
附註:	Source: Dissertations Abstracts International, Volume: 65-07, Section: B.
Contained By:	Dissertations Abstracts International65-07B.
標題:	Chemical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3102415click for full text (PQDT)
ISBN:	9780496499854

Microscopic models for the structure and permeability of the stratum corneum barrier layer of skin.
Wang, Tsuo-Feng.

Microscopic models for the structure and permeability of the stratum corneum barrier layer of skin. - 1 online resource (243 pages)

Source: Dissertations Abstracts International, Volume: 65-07, Section: B.

Thesis (Ph.D.)--State University of New York at Buffalo, 2003.

Includes bibliographical references

A study addressing both structure and diffusion theory was carried out to better understand permeation of molecules through the stratum corneum (SC), the primary barrier layer of skin. In the structural study (part I), analysis of micrographs of real skin sections led to quantitative determinations of key dimensions and-most significantly-the tortuosity of the intercellular lipid phase seen in 2-D cross section, quantifying the effective path length for diffusion. A geometrical model was subsequently developed to estimate the true tortuosity in 3-D space, which is not directly observable. The analysis of diffusion (part II) represented a significant tension of "brick-and-mortar" models of SC permeability, specifically addressing the roles played by lateral and transbilayer transport in the lipid phase, as well as permeability of the corneocyte phase. Solution of the governing equations by finite differences and relaxation led to quantitative understanding of the relative contributions of lipid (intercellular) and corneocyte (transcellular) pathways. For practical application, methods were developed to estimate partition and diffusion coefficients characterizing the lipid and corneocyte phases for the (very common) circumstance where experimental data on these input parameters may not be available. By matching the model to experimental data on SC permeability, new insights were obtained into the transbilayer mass transfer coefficient ktrans, a key (and poorly understood) parameter characterizing the rate of transport between lipid bilayers. The overall conclusions were that: (1) the tortuosity τ 2D of the lipid pathway is 12.42 and 4.47, for the respective cases of partially hydrated (unswollen) and fully hydrated (swollen) SC seen in 2-D cross section; (2) these figures translate into respective values for τ3D of 9.32 and 3.51 in three dimensions; (3) transbilayer transport is a key step in percutaneous permeation whether or not transcellular transport is dominant; (4) overall, ktrans decreases strongly with increasing permeant molecular weight, and weakly with increasing octanol-water partition coefficient (lipophilicity); (5) values of ktrans deduced from SC permeability data using our diffusion model are roughly consistent with limited available data on this parameter from liposome release experiments.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9780496499854Subjects--Topical Terms:

560457
Chemical engineering.
Subjects--Index Terms:

PermeabilityIndex Terms--Genre/Form:

542853
Electronic books.

Microscopic models for the structure and permeability of the stratum corneum barrier layer of skin.
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245 1 0 $a Microscopic models for the structure and permeability of the stratum corneum barrier layer of skin.
264 0 $c 2003
300 $a 1 online resource (243 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 65-07, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Nitsche, Johannes M.
502 $a Thesis (Ph.D.)--State University of New York at Buffalo, 2003.
504 $a Includes bibliographical references
520 $a A study addressing both structure and diffusion theory was carried out to better understand permeation of molecules through the stratum corneum (SC), the primary barrier layer of skin. In the structural study (part I), analysis of micrographs of real skin sections led to quantitative determinations of key dimensions and-most significantly-the tortuosity of the intercellular lipid phase seen in 2-D cross section, quantifying the effective path length for diffusion. A geometrical model was subsequently developed to estimate the true tortuosity in 3-D space, which is not directly observable. The analysis of diffusion (part II) represented a significant tension of "brick-and-mortar" models of SC permeability, specifically addressing the roles played by lateral and transbilayer transport in the lipid phase, as well as permeability of the corneocyte phase. Solution of the governing equations by finite differences and relaxation led to quantitative understanding of the relative contributions of lipid (intercellular) and corneocyte (transcellular) pathways. For practical application, methods were developed to estimate partition and diffusion coefficients characterizing the lipid and corneocyte phases for the (very common) circumstance where experimental data on these input parameters may not be available. By matching the model to experimental data on SC permeability, new insights were obtained into the transbilayer mass transfer coefficient ktrans, a key (and poorly understood) parameter characterizing the rate of transport between lipid bilayers. The overall conclusions were that: (1) the tortuosity τ 2D of the lipid pathway is 12.42 and 4.47, for the respective cases of partially hydrated (unswollen) and fully hydrated (swollen) SC seen in 2-D cross section; (2) these figures translate into respective values for τ3D of 9.32 and 3.51 in three dimensions; (3) transbilayer transport is a key step in percutaneous permeation whether or not transcellular transport is dominant; (4) overall, ktrans decreases strongly with increasing permeant molecular weight, and weakly with increasing octanol-water partition coefficient (lipophilicity); (5) values of ktrans deduced from SC permeability data using our diffusion model are roughly consistent with limited available data on this parameter from liposome release experiments.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Chemical engineering. $3 560457
650 4 $a Pharmaceuticals. $3 3562593
650 4 $a Pharmaceutical sciences. $3 3173021
653 $a Permeability
653 $a Skin
653 $a Stratum corneum
653 $a Transdermal
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0542
690 $a 0572
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710 2 $a State University of New York at Buffalo. $3 1017814
773 0 $t Dissertations Abstracts International $g 65-07B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3102415 $z click for full text (PQDT)