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Implications of V. cholerae Serotypes for Vaccine Development and Infection Outcomes.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Implications of V. cholerae Serotypes for Vaccine Development and Infection Outcomes./
Author:	Fakoya, Bolutife Olurotimi.
Description:	1 online resource (145 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-12, Section: B.
Contained By:	Dissertations Abstracts International83-12B.
Subject:	Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29209073click for full text (PQDT)
ISBN:	9798819381755

Implications of V. cholerae Serotypes for Vaccine Development and Infection Outcomes.
Fakoya, Bolutife Olurotimi.

Implications of V. cholerae Serotypes for Vaccine Development and Infection Outcomes. - 1 online resource (145 pages)

Source: Dissertations Abstracts International, Volume: 83-12, Section: B.

Thesis (Ph.D.)--Harvard University, 2022.

Includes bibliographical references

Vibrio cholerae, the cause of the diarrheal disease cholera, remains a major threat to global public health with approximately 3 million cases reported annually. V. cholerae colonize the human small intestine and possess a range of virulence factors that enable robust colonization of susceptible populations. Cholera vaccines are emerging as important tools for cholera prevention, but different vaccines (depending on their formulations) provide varying levels of protection against the major Ogawa and Inaba serotypes of V. cholerae. Here we describe how we used our knowledge of V. cholerae serotypes to optimize the immunogenicity and crossprotective efficacy of a novel live-attenuated cholera vaccine, refine a murine model of V. cholerae intestinal colonization for evaluating cholera vaccine efficacy, imagine a new paradigm for global cholera challenge studies, and investigate the role that O-antigen modification plays in defining both host and pathogen responses to infection. In summary, we characterize critical translational aspects of cholera vaccine development and elucidate the implications of V. cholerae serotypes on infection outcomes.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798819381755Subjects--Topical Terms:

536250
Microbiology.
Subjects--Index Terms:

Cholera vaccineIndex Terms--Genre/Form:

542853
Electronic books.

Implications of V. cholerae Serotypes for Vaccine Development and Infection Outcomes.
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500 $a Source: Dissertations Abstracts International, Volume: 83-12, Section: B.
500 $a Advisor: Waldor, Matthew.
502 $a Thesis (Ph.D.)--Harvard University, 2022.
504 $a Includes bibliographical references
520 $a Vibrio cholerae, the cause of the diarrheal disease cholera, remains a major threat to global public health with approximately 3 million cases reported annually. V. cholerae colonize the human small intestine and possess a range of virulence factors that enable robust colonization of susceptible populations. Cholera vaccines are emerging as important tools for cholera prevention, but different vaccines (depending on their formulations) provide varying levels of protection against the major Ogawa and Inaba serotypes of V. cholerae. Here we describe how we used our knowledge of V. cholerae serotypes to optimize the immunogenicity and crossprotective efficacy of a novel live-attenuated cholera vaccine, refine a murine model of V. cholerae intestinal colonization for evaluating cholera vaccine efficacy, imagine a new paradigm for global cholera challenge studies, and investigate the role that O-antigen modification plays in defining both host and pathogen responses to infection. In summary, we characterize critical translational aspects of cholera vaccine development and elucidate the implications of V. cholerae serotypes on infection outcomes.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Microbiology. $3 536250
650 4 $a Immunology. $3 611031
650 4 $a Public health. $3 534748
650 4 $a Pharmacology. $3 634543
650 4 $a Molecular biology. $3 517296
653 $a Cholera vaccine
653 $a Immunogenicity
653 $a Crossprotective efficacy
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773 0 $t Dissertations Abstracts International $g 83-12B.
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