東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Linked to FindBook

Google Book

Amazon

博客來

Optical Investigation of Microcircuit Computations in Mouse Primary Visual Cortex.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Optical Investigation of Microcircuit Computations in Mouse Primary Visual Cortex./
Author:	Jaffe, Anna Wang.
Description:	1 online resource (100 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-09, Section: B.
Contained By:	Dissertations Abstracts International83-09B.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28964301click for full text (PQDT)
ISBN:	9798209899082

Optical Investigation of Microcircuit Computations in Mouse Primary Visual Cortex.
Jaffe, Anna Wang.

Optical Investigation of Microcircuit Computations in Mouse Primary Visual Cortex. - 1 online resource (100 pages)

Source: Dissertations Abstracts International, Volume: 83-09, Section: B.

Thesis (Ph.D.)--Harvard University, 2022.

Includes bibliographical references

A fundamental challenge of visual cortical neuroscience is to understand how sensory representations are transformed within and across layers of primary visual cortex (V1). Visual signals are thought to propagate in a feedforward manner from the retina to the thalamus and then through the layered structure of V1, from layer 4 (L4) to layer 2/3 to layer 5. Here, we address one major step of visual processing: how are representations transformed within L4, the primary input layer of V1? We first developed a strategy to label neurons in L4. To understand computations during visual processing in awake animals, we then employed influence mapping, an approach developed by our lab to causally manipulate neural activity using in vivo single-neuron optical perturbations. We performed simultaneous two-photon optogenetic photostimulation of targeted individual neurons while imaging the responses of neighboring populations. By relating the influence of a neuron on other cells to their visual tuning properties, the computational function of neural activity patterns can then be inferred. Using this technique, we found that excitatory neurons in L4 strongly recruited activity from nearby but not distant cells, which was dependent on similarity in activity and certain tuning features such as preferred orientation and receptive field overlap. This result supports the idea that L4 amplifies visual signals via a feature-specific like-excites-like motif. These experiments have advanced our understanding of local transformations within L4 of V1. In addition, the technical approaches developed serve as a foundation for future studies of laminar cortical mechanisms that underlie visual processing, including comparing the transformations that occur within and between layers.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798209899082Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

CortexIndex Terms--Genre/Form:

542853
Electronic books.

Optical Investigation of Microcircuit Computations in Mouse Primary Visual Cortex.
LDR:03134nmm a2200385K 4500 001 2359720
005 20230917195226.5
006 m o d
007 cr mn ---uuuuu
008 241011s2022 xx obm 000 0 eng d
020 $a 9798209899082
035 $a (MiAaPQ)AAI28964301
035 $a AAI28964301
040 $a MiAaPQ $b eng $c MiAaPQ $d NTU
100 1 $a Jaffe, Anna Wang. $3 3700340
245 1 0 $a Optical Investigation of Microcircuit Computations in Mouse Primary Visual Cortex.
264 0 $c 2022
300 $a 1 online resource (100 pages)
336 $a text $b txt $2 rdacontent
337 $a computer $b c $2 rdamedia
338 $a online resource $b cr $2 rdacarrier
500 $a Source: Dissertations Abstracts International, Volume: 83-09, Section: B.
500 $a Advisor: Harvey, Christopher.
502 $a Thesis (Ph.D.)--Harvard University, 2022.
504 $a Includes bibliographical references
520 $a A fundamental challenge of visual cortical neuroscience is to understand how sensory representations are transformed within and across layers of primary visual cortex (V1). Visual signals are thought to propagate in a feedforward manner from the retina to the thalamus and then through the layered structure of V1, from layer 4 (L4) to layer 2/3 to layer 5. Here, we address one major step of visual processing: how are representations transformed within L4, the primary input layer of V1? We first developed a strategy to label neurons in L4. To understand computations during visual processing in awake animals, we then employed influence mapping, an approach developed by our lab to causally manipulate neural activity using in vivo single-neuron optical perturbations. We performed simultaneous two-photon optogenetic photostimulation of targeted individual neurons while imaging the responses of neighboring populations. By relating the influence of a neuron on other cells to their visual tuning properties, the computational function of neural activity patterns can then be inferred. Using this technique, we found that excitatory neurons in L4 strongly recruited activity from nearby but not distant cells, which was dependent on similarity in activity and certain tuning features such as preferred orientation and receptive field overlap. This result supports the idea that L4 amplifies visual signals via a feature-specific like-excites-like motif. These experiments have advanced our understanding of local transformations within L4 of V1. In addition, the technical approaches developed serve as a foundation for future studies of laminar cortical mechanisms that underlie visual processing, including comparing the transformations that occur within and between layers.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Neurosciences. $3 588700
650 4 $a Physiology. $3 518431
650 4 $a Physiological psychology. $3 2144820
653 $a Cortex
653 $a Optogenetics
653 $a Visual cortical neuroscience
653 $a Receptive field overlap
655 7 $a Electronic books. $2 lcsh $3 542853
690 $a 0317
690 $a 0989
690 $a 0719
710 2 $a ProQuest Information and Learning Co. $3 783688
710 2 $a Harvard University. $b Medical Sciences. $3 3181716
773 0 $t Dissertations Abstracts International $g 83-09B.
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28964301 $z click for full text (PQDT)