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Development and Evaluation of Transdermal Drug Delivery Systems for Anti Parkinsons and Antipsychotic Drugs.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development and Evaluation of Transdermal Drug Delivery Systems for Anti Parkinsons and Antipsychotic Drugs./
作者:	R., Sadashivaiah.
面頁冊數:	1 online resource (302 pages)
附註:	Source: Masters Abstracts International, Volume: 84-09.
Contained By:	Masters Abstracts International84-09.
標題:	Drug delivery systems. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30276174click for full text (PQDT)
ISBN:	9798374432916

Development and Evaluation of Transdermal Drug Delivery Systems for Anti Parkinsons and Antipsychotic Drugs.
R., Sadashivaiah.

Development and Evaluation of Transdermal Drug Delivery Systems for Anti Parkinsons and Antipsychotic Drugs. - 1 online resource (302 pages)

Source: Masters Abstracts International, Volume: 84-09.

Thesis (Ph.D.)--Rajiv Gandhi University of Health Sciences (India), 2021.

Includes bibliographical references

Objectives: To study the effect and optimization of chitosan and sodium alginate conjugates on permeation of ropinirole hydrochloride from transdermal patches and to study the effect and optimization of IPM as a permeation enhancer in the transdermal patch of paliperidone.Materials and methods: Initially, simple, sensitive and accurate stability-indicating RPHPLC and liquid chromatography-mass tandem spectroscopy methods were developed and validated for the quantification of ropinirole hydrochloride and paliperidone in API, tablets and rabbit plasma, respectively. Chitosan and sodium alginate conjugates were synthesized and characterized for browning and charring point, viscosity, TLC, ATRFTIR, DSC, 1H NMR and UV spectroscopy using Ellman's reagents. The ex vivo permeation kinetics of ropinirole hydrochloride and paliperidone alone and with eight permeation enhancers were screened. Two sets of twelve primary formulations of ropinirole hydrochloride were prepared by varying the ratios of chitosan: CTC and SA:SACC and nine primary transdermal patches of paliperidone were prepared by varying the ratios of EC:PVP K30 along with permeation enhancer IPM at a different concentration by solvent casting method. The formulated transdermal patches for both drugs were evaluated for texture, thickness, uniformity of weight, uniformity of drug content, flatness, folding endurance, elongation at break, tensile strength, moisture loss and uptake, WVTR, swelling index, surface pH and ex vivo skin permeation, The results obtained for all formulations were fed into Design-Expert® software to obtain the optimized transdermal patches. The optimized patches were evaluated for physicochemical, ex vivo permeation, residual solvent, powder X-ray diffraction, scanning electron microscopy, microbial, stability, skin irritation and in vivo relative bioavailability studies using rabbits.Results: The browning point, charring point, viscosity, TLC, ATR-FTIR, 1H NMR, UV spectroscopy using Ellman's reagent and DSC studies confirmed the thiolation process. IPM was a potential permeation enhancer for both the drugs was confirmed in ex vivo permeation experiment. FTIR and DSC analysis suggested that there were no interaction between drug and polymers and the amorphous form of the drug in the polymeric matrix was confirmed in PXRD. SEM images showed the uniform dispersion of the drug in the polymeric patch. The bacterial and fungal count was found to be within the pharmacopoeial limits and free from microorganisms. Gas chromatography confirms that the chloroform solvent present in the patch was within the toxic level. There was no skin irritation. The stability studies showed that all the parameters were well within the acceptable range. In vivo relative bioavailability studies on rabbits showed that therapeutic concentration of drug was present in the therapeutic window for a long time showed that minimum effective concentration can be achieved within systemic circulation with decreased lag time through transdermal patches.Conclusions: The study was concluded that there was a positive effect of conjugates (CTC, SACC) on ropinirole hydrochloride permeation and IPM as a permeation enhancer on paliperidone permeation from the transdermal patches. The matrix-type transdermal patches of ropinirole hydrochloride and paliperidone can deliver an effective amount of drugs for the treatment of chronic diseases like parkinson's disease and schizophrenia, respectively. It's an alternative to the oral drug delivery system.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798374432916Subjects--Topical Terms:

657987
Drug delivery systems.
Index Terms--Genre/Form:

542853
Electronic books.

Development and Evaluation of Transdermal Drug Delivery Systems for Anti Parkinsons and Antipsychotic Drugs.
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245 1 0 $a Development and Evaluation of Transdermal Drug Delivery Systems for Anti Parkinsons and Antipsychotic Drugs.
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504 $a Includes bibliographical references
520 $a Objectives: To study the effect and optimization of chitosan and sodium alginate conjugates on permeation of ropinirole hydrochloride from transdermal patches and to study the effect and optimization of IPM as a permeation enhancer in the transdermal patch of paliperidone.Materials and methods: Initially, simple, sensitive and accurate stability-indicating RPHPLC and liquid chromatography-mass tandem spectroscopy methods were developed and validated for the quantification of ropinirole hydrochloride and paliperidone in API, tablets and rabbit plasma, respectively. Chitosan and sodium alginate conjugates were synthesized and characterized for browning and charring point, viscosity, TLC, ATRFTIR, DSC, 1H NMR and UV spectroscopy using Ellman's reagents. The ex vivo permeation kinetics of ropinirole hydrochloride and paliperidone alone and with eight permeation enhancers were screened. Two sets of twelve primary formulations of ropinirole hydrochloride were prepared by varying the ratios of chitosan: CTC and SA:SACC and nine primary transdermal patches of paliperidone were prepared by varying the ratios of EC:PVP K30 along with permeation enhancer IPM at a different concentration by solvent casting method. The formulated transdermal patches for both drugs were evaluated for texture, thickness, uniformity of weight, uniformity of drug content, flatness, folding endurance, elongation at break, tensile strength, moisture loss and uptake, WVTR, swelling index, surface pH and ex vivo skin permeation, The results obtained for all formulations were fed into Design-Expert® software to obtain the optimized transdermal patches. The optimized patches were evaluated for physicochemical, ex vivo permeation, residual solvent, powder X-ray diffraction, scanning electron microscopy, microbial, stability, skin irritation and in vivo relative bioavailability studies using rabbits.Results: The browning point, charring point, viscosity, TLC, ATR-FTIR, 1H NMR, UV spectroscopy using Ellman's reagent and DSC studies confirmed the thiolation process. IPM was a potential permeation enhancer for both the drugs was confirmed in ex vivo permeation experiment. FTIR and DSC analysis suggested that there were no interaction between drug and polymers and the amorphous form of the drug in the polymeric matrix was confirmed in PXRD. SEM images showed the uniform dispersion of the drug in the polymeric patch. The bacterial and fungal count was found to be within the pharmacopoeial limits and free from microorganisms. Gas chromatography confirms that the chloroform solvent present in the patch was within the toxic level. There was no skin irritation. The stability studies showed that all the parameters were well within the acceptable range. In vivo relative bioavailability studies on rabbits showed that therapeutic concentration of drug was present in the therapeutic window for a long time showed that minimum effective concentration can be achieved within systemic circulation with decreased lag time through transdermal patches.Conclusions: The study was concluded that there was a positive effect of conjugates (CTC, SACC) on ropinirole hydrochloride permeation and IPM as a permeation enhancer on paliperidone permeation from the transdermal patches. The matrix-type transdermal patches of ropinirole hydrochloride and paliperidone can deliver an effective amount of drugs for the treatment of chronic diseases like parkinson's disease and schizophrenia, respectively. It's an alternative to the oral drug delivery system.
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