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Ultrasound-Stimulated Microbubble Induced Fluid Transport in Poroviscohyperelastic Media.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Ultrasound-Stimulated Microbubble Induced Fluid Transport in Poroviscohyperelastic Media./
Author:	Kiezun, Kevin.
Description:	1 online resource (166 pages)
Notes:	Source: Masters Abstracts International, Volume: 83-10.
Contained By:	Masters Abstracts International83-10.
Subject:	Biophysics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28962032click for full text (PQDT)
ISBN:	9798209907435

Ultrasound-Stimulated Microbubble Induced Fluid Transport in Poroviscohyperelastic Media.
Kiezun, Kevin.

Ultrasound-Stimulated Microbubble Induced Fluid Transport in Poroviscohyperelastic Media. - 1 online resource (166 pages)

Source: Masters Abstracts International, Volume: 83-10.

Thesis (M.Sc.)--University of Toronto (Canada), 2022.

Includes bibliographical references

Ultrasound stimulated microbubbles have been shown to be capable of inducing deformations of biologically relevant boundaries through both volumetric oscillations and primary radiation forces. In this thesis, it is proposed that microbubble indentation upon saturated poroviscohyperelastic media, resulting from primary radiation forces, plays a role in the transport of fluids into such media. This mechanism is investigated via finite element analysis, where a single load-unload cycle, of a 5μm microbubble to a peak depth of 1μm, is found to cause pore pressure elevation and effective fluid flow velocities of up to 2.7mm/s within the medium. Importantly, fluid exchange between the overlying fluid layer and the poroviscohyperelastic medium occurs in a manner that extends multiple microbubble-contact radii away from the indentation site. These findings offer insight into an unexplored microbubble-mediated fluid transport mechanism, suggesting that the indentation aspect of the microbubble-tissue interaction may play a role in enhancing therapeutic agent delivery.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798209907435Subjects--Topical Terms:

518360
Biophysics.
Subjects--Index Terms:

Drug deliveryIndex Terms--Genre/Form:

542853
Electronic books.

Ultrasound-Stimulated Microbubble Induced Fluid Transport in Poroviscohyperelastic Media.
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100 1 $a Kiezun, Kevin. $3 3699448
245 1 0 $a Ultrasound-Stimulated Microbubble Induced Fluid Transport in Poroviscohyperelastic Media.
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300 $a 1 online resource (166 pages)
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500 $a Source: Masters Abstracts International, Volume: 83-10.
500 $a Advisor: Goertz, David E.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2022.
504 $a Includes bibliographical references
520 $a Ultrasound stimulated microbubbles have been shown to be capable of inducing deformations of biologically relevant boundaries through both volumetric oscillations and primary radiation forces. In this thesis, it is proposed that microbubble indentation upon saturated poroviscohyperelastic media, resulting from primary radiation forces, plays a role in the transport of fluids into such media. This mechanism is investigated via finite element analysis, where a single load-unload cycle, of a 5μm microbubble to a peak depth of 1μm, is found to cause pore pressure elevation and effective fluid flow velocities of up to 2.7mm/s within the medium. Importantly, fluid exchange between the overlying fluid layer and the poroviscohyperelastic medium occurs in a manner that extends multiple microbubble-contact radii away from the indentation site. These findings offer insight into an unexplored microbubble-mediated fluid transport mechanism, suggesting that the indentation aspect of the microbubble-tissue interaction may play a role in enhancing therapeutic agent delivery.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Biophysics. $3 518360
653 $a Drug delivery
653 $a Finite element method
653 $a Fluid transport
653 $a Indentation
653 $a Microbubbles
653 $a Ultrasound
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710 2 $a University of Toronto (Canada). $b Medical Biophysics. $3 3181600
773 0 $t Masters Abstracts International $g 83-10.
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