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Mass Spectrometry Guided Development of a Controlled Release Nanotransfersome Transdermal Drug Delivery System.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Mass Spectrometry Guided Development of a Controlled Release Nanotransfersome Transdermal Drug Delivery System./
作者:	Kiselak, Thomas Dieter.
面頁冊數:	1 online resource (116 pages)
附註:	Source: Dissertations Abstracts International, Volume: 83-02, Section: B.
Contained By:	Dissertations Abstracts International83-02B.
標題:	Metabolites. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28690921click for full text (PQDT)
ISBN:	9798534697841

Mass Spectrometry Guided Development of a Controlled Release Nanotransfersome Transdermal Drug Delivery System.
Kiselak, Thomas Dieter.

Mass Spectrometry Guided Development of a Controlled Release Nanotransfersome Transdermal Drug Delivery System. - 1 online resource (116 pages)

Source: Dissertations Abstracts International, Volume: 83-02, Section: B.

Thesis (Ph.D.)--University of North Texas, 2020.

Includes bibliographical references

Poor medical adherence attributed to patient compliance has impacted the medical community, at times, in a deleterious fashion. To combat this, the medical community has attempted to provide therapeutics in the form of absorption enhancing techniques. To improve the absorption rate techniques such as drug encapsulation using proteins, liposomes, or nanotransfersomes have been developed using mass spectrometry. These techniques, have aided in the enhanced absorption of analytes with low bioavailability, including curcumin, simvastatin, and lysozyme. Specifically, mass spectrometry allows for the development and monitoring of nanotransfersome encapsulated analytes and the permeation across the dermal membrane. This transdermal delivery would eliminate the problems encountered during first pass metabolism, while allowing for higher concentrations of analyte to be maintained in the blood serum. This can be coupled to a thermosensitive gelatin that provides for a dose control mechanism to be accomplished, allowing multiple doses to be delivered using one transdermal patch system. The novel delivery system developed using mass spectrometry, allows the analyte to be delivered into the circulatory system at a controlled dosage, via transdermal absorption. This system will aid in eliminating problems associated with patient compliance, as the patient is no longer reliant on memory to self-dose. Further, this system mitigates the concerns of patients overdosing with more potent pharmaceuticals.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798534697841Subjects--Topical Terms:

683644
Metabolites.
Subjects--Index Terms:

NanotransfersomeIndex Terms--Genre/Form:

542853
Electronic books.

Mass Spectrometry Guided Development of a Controlled Release Nanotransfersome Transdermal Drug Delivery System.
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504 $a Includes bibliographical references
520 $a Poor medical adherence attributed to patient compliance has impacted the medical community, at times, in a deleterious fashion. To combat this, the medical community has attempted to provide therapeutics in the form of absorption enhancing techniques. To improve the absorption rate techniques such as drug encapsulation using proteins, liposomes, or nanotransfersomes have been developed using mass spectrometry. These techniques, have aided in the enhanced absorption of analytes with low bioavailability, including curcumin, simvastatin, and lysozyme. Specifically, mass spectrometry allows for the development and monitoring of nanotransfersome encapsulated analytes and the permeation across the dermal membrane. This transdermal delivery would eliminate the problems encountered during first pass metabolism, while allowing for higher concentrations of analyte to be maintained in the blood serum. This can be coupled to a thermosensitive gelatin that provides for a dose control mechanism to be accomplished, allowing multiple doses to be delivered using one transdermal patch system. The novel delivery system developed using mass spectrometry, allows the analyte to be delivered into the circulatory system at a controlled dosage, via transdermal absorption. This system will aid in eliminating problems associated with patient compliance, as the patient is no longer reliant on memory to self-dose. Further, this system mitigates the concerns of patients overdosing with more potent pharmaceuticals.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Metabolites. $3 683644
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Biochemistry. $3 518028
650 4 $a Chemistry. $3 516420
650 4 $a Therapy. $3 3343697
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Dermatology. $3 829009
650 4 $a Food. $3 551593
650 4 $a Ions. $3 814923
650 4 $a Brain research. $3 3561789
650 4 $a Metabolism. $3 541349
650 4 $a Lipids. $3 558980
650 4 $a Peptides. $3 605772
650 4 $a Research & development--R&D. $3 3554335
650 4 $a Transdermal medication. $3 915592
650 4 $a Drug dosages. $3 3557732
650 4 $a Laboratory animals. $3 523934
650 4 $a Bioavailability. $3 875104
650 4 $a Proteins. $3 558769
650 4 $a Membranes. $3 1531702
650 4 $a Blood-brain barrier. $3 812171
650 4 $a Pharmacy. $3 636101
650 4 $a Drug delivery systems. $3 657987
650 4 $a Heart attacks. $3 3544977
650 4 $a Permeability. $3 915594
650 4 $a Hypertension. $3 825110
650 4 $a Medical research. $2 bicssc $3 1556686
650 4 $a Cardiovascular disease. $3 3564561
650 4 $a Cosmetics. $3 910868
653 $a Nanotransfersome
653 $a PAMPA
653 $a Mass spectrometry
653 $a Transdermal drug delivery
653 $a Controlled release
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690 $a 0487
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690 $a 0485
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710 2 $a University of North Texas. $b Department of Chemistry. $3 3683881
773 0 $t Dissertations Abstracts International $g 83-02B.
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