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Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD).
Record Type:
Electronic resources : Monograph/item
Title/Author:
Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD)./
Author:
Te, Lucas Jaryd.
Description:
1 online resource (196 pages)
Notes:
Source: Masters Abstracts International, Volume: 83-01.
Contained By:
Masters Abstracts International83-01.
Subject:
Biology. -
Online resource:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28263162click for full text (PQDT)
ISBN:
9798522942939
Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD).
Te, Lucas Jaryd.
Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD).
- 1 online resource (196 pages)
Source: Masters Abstracts International, Volume: 83-01.
Thesis (M.Sc.)--University of Toronto (Canada), 2021.
Includes bibliographical references
Skeletal muscle is essential for mobility and its health relies upon innervation. Peripheral nerve injury denervates target skeletal muscle, causing immediate loss of function, atrophy, and development of fibrosis. Delayed re-innervation can result in permanent functional loss, leading to a myriad of physical, financial, social, and psychological burdens on affected individuals. Ultrasound-mediated Gene Delivery (UMGD) is a relatively novel technique that has been shown to provide localized and effective gene therapy in vivo. We hypothesize that UMGD of myogenic genes IGF-1, VEGF, and Ang-1 would sustain the mass and regenerative potential of denervated muscle awaiting reinnervation. After two weeks, UMGD of these genes mildly increased gross muscle weight, Type II fibre CSA, and vascularization compared to denervated muscle given no transgene. We have shown that UMGD is a viable model for targeted gene delivery to skeletal muscle through partial prevention of the atrophy and vascular loss induced by denervation injury.
Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023
Mode of access: World Wide Web
ISBN: 9798522942939Subjects--Topical Terms:
522710
Biology.
Subjects--Index Terms:
DenervationIndex Terms--Genre/Form:
542853
Electronic books.
Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD).
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Te, Lucas Jaryd.
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Enabling Skeletal Muscle Repair and Functional Recovery Following Denervation-Induced Injury Using Ultrasound Mediated Gene Delivery (UMGD).
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Source: Masters Abstracts International, Volume: 83-01.
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Advisor: Batt, Jane.
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Thesis (M.Sc.)--University of Toronto (Canada), 2021.
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Includes bibliographical references
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Skeletal muscle is essential for mobility and its health relies upon innervation. Peripheral nerve injury denervates target skeletal muscle, causing immediate loss of function, atrophy, and development of fibrosis. Delayed re-innervation can result in permanent functional loss, leading to a myriad of physical, financial, social, and psychological burdens on affected individuals. Ultrasound-mediated Gene Delivery (UMGD) is a relatively novel technique that has been shown to provide localized and effective gene therapy in vivo. We hypothesize that UMGD of myogenic genes IGF-1, VEGF, and Ang-1 would sustain the mass and regenerative potential of denervated muscle awaiting reinnervation. After two weeks, UMGD of these genes mildly increased gross muscle weight, Type II fibre CSA, and vascularization compared to denervated muscle given no transgene. We have shown that UMGD is a viable model for targeted gene delivery to skeletal muscle through partial prevention of the atrophy and vascular loss induced by denervation injury.
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Electronic reproduction.
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Ann Arbor, Mich. :
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ProQuest,
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2023
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Mode of access: World Wide Web
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Gene therapy
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28263162
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click for full text (PQDT)
based on 0 review(s)
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