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Therapeutic Ultrasound-Induced Insulin Release.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Therapeutic Ultrasound-Induced Insulin Release./
作者:	Singh, Tania.
面頁冊數:	1 online resource (55 pages)
附註:	Source: Masters Abstracts International, Volume: 80-12.
Contained By:	Masters Abstracts International80-12.
標題:	Endocrinology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=13884622click for full text (PQDT)
ISBN:	9781392174562

Therapeutic Ultrasound-Induced Insulin Release.
Singh, Tania.

Therapeutic Ultrasound-Induced Insulin Release. - 1 online resource (55 pages)

Source: Masters Abstracts International, Volume: 80-12.

Thesis (M.S.)--The George Washington University, 2019.

Includes bibliographical references

Type 2 diabetes mellitus (T2DM) is a complex and chronic metabolic disease that results from the interplay of systemic insulin resistance of peripheral tissues and insufficient compensatory insulin secretion from pancreatic beta cells (American Diabetes Association, 2010; Kahn, 2001). The objective of this thesis was to investigate the safety and efficacy of low-frequency, low-intensity therapeutic ultrasound-induced insulin release as a non-pharmacological approach for modulating endogenous insulin concentrations in the early stages of T2DM. We utilized a preclinical in vivo murine model and multi-physics computational modeling of the human abdomen to assess the safety, feasibility, and efficacy of the proposed therapy. We observed an increase of 0.30 ± 0.32 ng/mL (mean ± std) in blood insulin concentration in vivo immediately after a five-minute sonication compared to a decrease of 0.37 ± 0.27 ng/mL in sham treated animals in terminal studies (n < 6, p < 0.005). There was no difference observed in the change in glucose or glucagon concentrations between the groups. Comparisons of H&E-stained terminal and survival pancreatic tissue showed no visible differences or evidence of damage. Computational modeling studies showed that continuous sonication at 1 MHz through a fluid-filled stomach results in a maximum pressure of 181 kPa and maximum temperature of 39.7ºC. This study is the first step is assessing the translational potential of low-frequency, low-intensity therapeutic ultrasound as a potential treatment for the early stages of T2DM as we have demonstrated that it is feasible to safely and effectively modulate insulin release noninvasively.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9781392174562Subjects--Topical Terms:

610914
Endocrinology.
Subjects--Index Terms:

Insulin secretionIndex Terms--Genre/Form:

542853
Electronic books.

Therapeutic Ultrasound-Induced Insulin Release.
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500 $a Source: Masters Abstracts International, Volume: 80-12.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Kay, Matthew.
502 $a Thesis (M.S.)--The George Washington University, 2019.
504 $a Includes bibliographical references
520 $a Type 2 diabetes mellitus (T2DM) is a complex and chronic metabolic disease that results from the interplay of systemic insulin resistance of peripheral tissues and insufficient compensatory insulin secretion from pancreatic beta cells (American Diabetes Association, 2010; Kahn, 2001). The objective of this thesis was to investigate the safety and efficacy of low-frequency, low-intensity therapeutic ultrasound-induced insulin release as a non-pharmacological approach for modulating endogenous insulin concentrations in the early stages of T2DM. We utilized a preclinical in vivo murine model and multi-physics computational modeling of the human abdomen to assess the safety, feasibility, and efficacy of the proposed therapy. We observed an increase of 0.30 ± 0.32 ng/mL (mean ± std) in blood insulin concentration in vivo immediately after a five-minute sonication compared to a decrease of 0.37 ± 0.27 ng/mL in sham treated animals in terminal studies (n < 6, p < 0.005). There was no difference observed in the change in glucose or glucagon concentrations between the groups. Comparisons of H&E-stained terminal and survival pancreatic tissue showed no visible differences or evidence of damage. Computational modeling studies showed that continuous sonication at 1 MHz through a fluid-filled stomach results in a maximum pressure of 181 kPa and maximum temperature of 39.7ºC. This study is the first step is assessing the translational potential of low-frequency, low-intensity therapeutic ultrasound as a potential treatment for the early stages of T2DM as we have demonstrated that it is feasible to safely and effectively modulate insulin release noninvasively.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Endocrinology. $3 610914
650 4 $a Biomedical engineering. $3 535387
653 $a Insulin secretion
653 $a Therapeutic ultrasound
653 $a Type 2 diabetes
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690 $a 0409
690 $a 0541
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710 2 $a The George Washington University. $b Biomedical Engineering. $3 3544440
773 0 $t Masters Abstracts International $g 80-12.
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