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Spatially Resolved Molecular Dysfunction in the Prefrontal Cortex of Patients with Amyotrophic Lateral Sclerosis (ALS).

Record Type:	Electronic resources : Monograph/item
Title/Author:	Spatially Resolved Molecular Dysfunction in the Prefrontal Cortex of Patients with Amyotrophic Lateral Sclerosis (ALS)./
Author:	Petrescu, Joana.
Description:	1 online resource (153 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-07, Section: B.
Contained By:	Dissertations Abstracts International84-07B.
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30244458click for full text (PQDT)
ISBN:	9798368439181

Spatially Resolved Molecular Dysfunction in the Prefrontal Cortex of Patients with Amyotrophic Lateral Sclerosis (ALS).
Petrescu, Joana.

Spatially Resolved Molecular Dysfunction in the Prefrontal Cortex of Patients with Amyotrophic Lateral Sclerosis (ALS). - 1 online resource (153 pages)

Source: Dissertations Abstracts International, Volume: 84-07, Section: B.

Thesis (Ph.D.)--Columbia University, 2023.

Includes bibliographical references

Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) represents a spectrum of neurodegenerative disease with clinical presentations ranging from progressive paralysis to cognitive impairment. Approximately 15% of ALS-FTD patients initially presenting with motor symptoms also receive a diagnosis of dementia, but a majority of these patients demonstrate some level of cognitive impairment over the course of disease. Identifying molecular pathways that contribute to the development of cognitive deficits in ALS-FTD has thus far been limited by the quality of clinical information and postmortem tissue preservation as well as available technologies. This thesis aims to investigate early stages of cognitive involvement in ALS-FTD using postmortem tissues from a cohort of non-demented ALS patients who have had cognitive and pathological phenotyping. Spatially resolved transcriptome profiling of prefrontal cortex tissues from this cohort identifies dysregulated pathways in non-motor regions, contributing to our understanding of molecular perturbations underlying cognitive impairment in ALS-FTD.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798368439181Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Frontotemporal dementiaIndex Terms--Genre/Form:

542853
Electronic books.

Spatially Resolved Molecular Dysfunction in the Prefrontal Cortex of Patients with Amyotrophic Lateral Sclerosis (ALS).
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