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Building Up Three-Dimensional Molecules via Novel Lewis Acid and/or Photosensitization Promoted Cycloadditions.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Building Up Three-Dimensional Molecules via Novel Lewis Acid and/or Photosensitization Promoted Cycloadditions./
作者:	Guo, Renyu.
面頁冊數:	1 online resource (834 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
Contained By:	Dissertations Abstracts International84-01B.
標題:	Chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29254506click for full text (PQDT)
ISBN:	9798834027089

Building Up Three-Dimensional Molecules via Novel Lewis Acid and/or Photosensitization Promoted Cycloadditions.
Guo, Renyu.

Building Up Three-Dimensional Molecules via Novel Lewis Acid and/or Photosensitization Promoted Cycloadditions. - 1 online resource (834 pages)

Source: Dissertations Abstracts International, Volume: 84-01, Section: B.

Thesis (Ph.D.)--Indiana University, 2022.

Includes bibliographical references

Escaping from flatland to incorporate three-dimensional architectures often improves the drug-like properties of the resulting molecules, such as solubility, lipophilicity and metabolic stability. Cycloaddition reactions are among the most efficient and atom-economical approaches to quickly build up molecular complexity from readily available alkenes. This document discusses how we incorporate Lewis acid and/or photosensitization as novel tools in cycloadditions to access three-dimensional molecules, specifically for the following three prats: (1) Applying Lewis acid catalyzed chirality transfer [2+2]-cycloadditions into the enantioselectivetotal syntheses of (-)-cajanusine and (+)-hippilde J, and formal synthesis of endiandric acids; (2) Development and detailed mechanistic study of Lewis acid promoted dearomativecycloaddition of quinolines initiated by photosensitization; (3) Development of photosensitized strain release [2π+2σ] cycloaddition to synthesizeunderdeveloped bioisostere [2.1.1]-bicyclohexanes.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798834027089Subjects--Topical Terms:

516420
Chemistry.
Subjects--Index Terms:

BioisostereIndex Terms--Genre/Form:

542853
Electronic books.

Building Up Three-Dimensional Molecules via Novel Lewis Acid and/or Photosensitization Promoted Cycloadditions.
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