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Differential Profiling for Metabolomics and Glycomics by Mass Spectrometry.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Differential Profiling for Metabolomics and Glycomics by Mass Spectrometry./
Author:	Wang, Ziyu.
Description:	1 online resource (205 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 84-05, Section: B.
Contained By:	Dissertations Abstracts International84-05B.
Subject:	Analytical chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29398966click for full text (PQDT)
ISBN:	9798352954614

Differential Profiling for Metabolomics and Glycomics by Mass Spectrometry.
Wang, Ziyu.

Differential Profiling for Metabolomics and Glycomics by Mass Spectrometry. - 1 online resource (205 pages)

Source: Dissertations Abstracts International, Volume: 84-05, Section: B.

Thesis (Ph.D.)--Indiana University, 2022.

Includes bibliographical references

Mass spectrometry-based techniques have been widely applied to the characterization of numerous chemical entities as methods to diagnose disease. In a first project, we are studying glycomics and how glycosylation changes with disease state. Previous studies have shown an association of aberrant glycosylation with cancers and autoimmune and inflammatory diseases. With matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), we have profiled N- and O-glycans derived from human urinary exosomes and have quantified differences between patients with prostate cancer and disease-free individuals. We have also used liquid chromatography-mass spectrometry (LC-MS) to enrich and characterize the structures of sulfated N-glycans derived from human urinary exosomes. In a second project, we are studying metabolomics and how the metabolome of various organisms' changes during exposure to toxicants. The metabolome represents a molecular phenotype within organisms and changes when exposed to the local environment, which may, in turn, lead to diseases, such as cancers and obesity. We have used direct-infusion mass spectrometry (DI-MS) to analyze metabolites derived from several organisms, including fruit flies and zebrafish, that have been exposed to higher concentration of arsenic. Changes in the metabolome have been tracked over multiple time points and concentrations of arsenic and compared among organisms. In both studies, we have evaluated the molecular compositions and structures of glycans and metabolites with MS techniques and qualitatively and quantitatively assessed how they change due to disease state and exposure to better understand the mechanisms of disease progression.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798352954614Subjects--Topical Terms:

3168300
Analytical chemistry.
Subjects--Index Terms:

Mass spectrometryIndex Terms--Genre/Form:

542853
Electronic books.

Differential Profiling for Metabolomics and Glycomics by Mass Spectrometry.
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