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Design, Fabrication, and Implantation Control of Flexible Neural Microprobes for Medical Neurology Applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Design, Fabrication, and Implantation Control of Flexible Neural Microprobes for Medical Neurology Applications./
Author:	Wang, Yi.
Description:	1 online resource (142 pages)
Notes:	Source: Dissertations Abstracts International, Volume: 83-11, Section: B.
Contained By:	Dissertations Abstracts International83-11B.
Subject:	Metals. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29071259click for full text (PQDT)
ISBN:	9798426868434

Design, Fabrication, and Implantation Control of Flexible Neural Microprobes for Medical Neurology Applications.
Wang, Yi.

Design, Fabrication, and Implantation Control of Flexible Neural Microprobes for Medical Neurology Applications. - 1 online resource (142 pages)

Source: Dissertations Abstracts International, Volume: 83-11, Section: B.

Thesis (Ph.D.)--North Carolina State University, 2022.

Includes bibliographical references

This paper presents a new fMRI-compatible flexible neural microprobe and the corresponding flexible neural microprobe implantation strategy using three-dimensional ultrasonic vibration with bio-dissolvable insertion guides. A flexible neural microprobe is a powerful tool for neuromodulation and recording in neuroscience and medical neurology treatments. The designed microprobe of interest in this paper needs to be conducted under functional Magnetic Resonance Imaging (fMRI) for neuroscience studies and investigating circuit-level modulation in a wholebrain scale. The developed neural microprobe was designed to simultaneously record and/or stimulate the neural action potentials under the fMRI to further explore the precise neurophysiological mechanisms and diagnose/control brain diseases. The materials used for the neural microprobe were comprehensively selected for fMRI compatibility. The detailed fabrication procedures of the fMRI compatible flexible neural microprobes were developed. The fabricated neural microprobes were characterized for the validation of the effectiveness.To successfully implant the flexible neural microprobes with minimized tissue damage, this paper presents a method of applying a three-dimensional longitudinal-twisting (L&T) ultrasonic vibration with a bio-dissolvable insertion guide for flexible planar microelectrode implantation. Due to the thin and flexible substrate of the neural probe, the flexible microprobes are susceptible to buckling and bending during insertion. That leads to the deflection of flexible microelectrodes and even the failure of implantation to successfully reach the target location in the brain during surgery. The proposed longitudinal-twisting vibration is applied to decrease the insertion friction force, thereby reducing the insertion force, microprobe bending, and tissue damage for a successful implant. To generate longitudinal-twisting vibration, a new design of a 3D printed waveguide-based longitudinal-twisting ultrasonic vibratory insertion device is presented in this paper. With the aim to improve the stiffness of neural microprobe and success rate, a bio-dissolvable insertion guide is designed in this paper. It is to reduce the buckling equivalent effective length of a flexible neural probe and thus to enhance the insertion stiffness. The insertion guide is made of the PEG bio-dissolvable material that can be easily flushed away during implantation by water, avoiding secondary damage and interference with the implanted neural probe during surgery.In vitro and in vivo laboratory experiments were conducted in a surgery room with fMRI for testing and validation. The results were presented in this paper. The experimental results show the proposed new methods are promising in accurately implanting the developed flexible neural microprobe with minimizing implantation bending and tissue damages. The presented design and fabrication of flexible microprobes can be used for medical neuroscience discovery and treatments. The presented method and control strategy can also be readily scaled up for various neural microprobe implantation.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798426868434Subjects--Topical Terms:

601053
Metals.
Index Terms--Genre/Form:

542853
Electronic books.

Design, Fabrication, and Implantation Control of Flexible Neural Microprobes for Medical Neurology Applications.
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245 1 0 $a Design, Fabrication, and Implantation Control of Flexible Neural Microprobes for Medical Neurology Applications.
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300 $a 1 online resource (142 pages)
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500 $a Source: Dissertations Abstracts International, Volume: 83-11, Section: B.
500 $a Advisor: Chow, Mo-Yuen ; Cohen, Paul ; Shih, Yen-Yu Ian ; Dong, Jingyan ; Lee, Yuan-Shin.
502 $a Thesis (Ph.D.)--North Carolina State University, 2022.
504 $a Includes bibliographical references
520 $a This paper presents a new fMRI-compatible flexible neural microprobe and the corresponding flexible neural microprobe implantation strategy using three-dimensional ultrasonic vibration with bio-dissolvable insertion guides. A flexible neural microprobe is a powerful tool for neuromodulation and recording in neuroscience and medical neurology treatments. The designed microprobe of interest in this paper needs to be conducted under functional Magnetic Resonance Imaging (fMRI) for neuroscience studies and investigating circuit-level modulation in a wholebrain scale. The developed neural microprobe was designed to simultaneously record and/or stimulate the neural action potentials under the fMRI to further explore the precise neurophysiological mechanisms and diagnose/control brain diseases. The materials used for the neural microprobe were comprehensively selected for fMRI compatibility. The detailed fabrication procedures of the fMRI compatible flexible neural microprobes were developed. The fabricated neural microprobes were characterized for the validation of the effectiveness.To successfully implant the flexible neural microprobes with minimized tissue damage, this paper presents a method of applying a three-dimensional longitudinal-twisting (L&T) ultrasonic vibration with a bio-dissolvable insertion guide for flexible planar microelectrode implantation. Due to the thin and flexible substrate of the neural probe, the flexible microprobes are susceptible to buckling and bending during insertion. That leads to the deflection of flexible microelectrodes and even the failure of implantation to successfully reach the target location in the brain during surgery. The proposed longitudinal-twisting vibration is applied to decrease the insertion friction force, thereby reducing the insertion force, microprobe bending, and tissue damage for a successful implant. To generate longitudinal-twisting vibration, a new design of a 3D printed waveguide-based longitudinal-twisting ultrasonic vibratory insertion device is presented in this paper. With the aim to improve the stiffness of neural microprobe and success rate, a bio-dissolvable insertion guide is designed in this paper. It is to reduce the buckling equivalent effective length of a flexible neural probe and thus to enhance the insertion stiffness. The insertion guide is made of the PEG bio-dissolvable material that can be easily flushed away during implantation by water, avoiding secondary damage and interference with the implanted neural probe during surgery.In vitro and in vivo laboratory experiments were conducted in a surgery room with fMRI for testing and validation. The results were presented in this paper. The experimental results show the proposed new methods are promising in accurately implanting the developed flexible neural microprobe with minimizing implantation bending and tissue damages. The presented design and fabrication of flexible microprobes can be used for medical neuroscience discovery and treatments. The presented method and control strategy can also be readily scaled up for various neural microprobe implantation.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
650 4 $a Metals. $3 601053
650 4 $a Gold. $3 659820
650 4 $a Transplants & implants. $3 3562683
650 4 $a Brain research. $3 3561789
650 4 $a Silver. $3 2006426
650 4 $a Injuries. $3 3563044
650 4 $a Neurosciences. $3 588700
650 4 $a Materials selection. $3 3689238
650 4 $a Research & development--R&D. $3 3554335
650 4 $a Vibration. $3 544256
650 4 $a Polymers. $3 535398
650 4 $a Blood-brain barrier. $3 812171
650 4 $a Spectrum analysis. $3 520440
650 4 $a Surgery. $3 707153
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650 4 $a Magnetic resonance imaging. $3 554355
650 4 $a Medical research. $2 bicssc $3 1556686
650 4 $a Flexibility. $3 3560705
650 4 $a Mapping. $3 3355992
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773 0 $t Dissertations Abstracts International $g 83-11B.
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