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Charge-Enhanced Organocatalysts : = Synthesis and Application toward Symmetric and Asymmetric Reactions.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Charge-Enhanced Organocatalysts :/
其他題名:	Synthesis and Application toward Symmetric and Asymmetric Reactions.
作者:	Riegel, George Frederic, IV.
面頁冊數:	1 online resource (315 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-03, Section: B.
Contained By:	Dissertations Abstracts International84-03B.
標題:	Chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28964519click for full text (PQDT)
ISBN:	9798845407627

Charge-Enhanced Organocatalysts : = Synthesis and Application toward Symmetric and Asymmetric Reactions.
Riegel, George Frederic, IV.

Charge-Enhanced Organocatalysts :Synthesis and Application toward Symmetric and Asymmetric Reactions. - 1 online resource (315 pages)

Source: Dissertations Abstracts International, Volume: 84-03, Section: B.

Thesis (Ph.D.)--University of Minnesota, 2022.

Includes bibliographical references

Hydrogen bonds are ubiquitous in Nature and are the principal interaction through which enzymes catalyze reactions. Bronsted acid organocatalysts mimic this process and present a greener alternative to metal-based species as the former do not contribute to the consumption of limited metal resources or the production of toxic metal wastes. Despite these benefits, organocatalysts have remained underutilized in industrial processes because they typically have low activity compared to their inorganic counterparts. In 2015, the Kass group demonstrated that Bronsted acidity and organocatalytic activity could be significantly enhanced in low-polarity media through the incorporation of formal positive charges. This principle has since been extended to common organocatalyst scaffolds such as thioureas and phosphoric acids. This dissertation details the further enhancement of Bronsted acidity in low-polarity solvents by the concerted action of positive charges and electron-withdrawing groups and a study on the implications of catalyst acidity on the rate of Friedel-Crafts alkylation reactions. In addition, the interactions of charged thioureas and Bronsted acidic co-catalysts are explored and the charge-enhanced acidity approach is extended to asymmetric TADDOL organocatalysis.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798845407627Subjects--Topical Terms:

516420
Chemistry.
Subjects--Index Terms:

Bronsted acid catalysisIndex Terms--Genre/Form:

542853
Electronic books.

Charge-Enhanced Organocatalysts : = Synthesis and Application toward Symmetric and Asymmetric Reactions.
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502 $a Thesis (Ph.D.)--University of Minnesota, 2022.
504 $a Includes bibliographical references
520 $a Hydrogen bonds are ubiquitous in Nature and are the principal interaction through which enzymes catalyze reactions. Bronsted acid organocatalysts mimic this process and present a greener alternative to metal-based species as the former do not contribute to the consumption of limited metal resources or the production of toxic metal wastes. Despite these benefits, organocatalysts have remained underutilized in industrial processes because they typically have low activity compared to their inorganic counterparts. In 2015, the Kass group demonstrated that Bronsted acidity and organocatalytic activity could be significantly enhanced in low-polarity media through the incorporation of formal positive charges. This principle has since been extended to common organocatalyst scaffolds such as thioureas and phosphoric acids. This dissertation details the further enhancement of Bronsted acidity in low-polarity solvents by the concerted action of positive charges and electron-withdrawing groups and a study on the implications of catalyst acidity on the rate of Friedel-Crafts alkylation reactions. In addition, the interactions of charged thioureas and Bronsted acidic co-catalysts are explored and the charge-enhanced acidity approach is extended to asymmetric TADDOL organocatalysis.
533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
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653 $a Bronsted acid catalysis
653 $a Metal-free catalyst
653 $a Organocatalysis
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