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Neurodevelopmental Factors Contributing to Substance Use and Mental Illness.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Neurodevelopmental Factors Contributing to Substance Use and Mental Illness./
作者:	Sullivan, Emily D.
面頁冊數:	1 online resource (133 pages)
附註:	Source: Dissertations Abstracts International, Volume: 83-11, Section: B.
Contained By:	Dissertations Abstracts International83-11B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29208967click for full text (PQDT)
ISBN:	9798438758617

Neurodevelopmental Factors Contributing to Substance Use and Mental Illness.
Sullivan, Emily D.

Neurodevelopmental Factors Contributing to Substance Use and Mental Illness. - 1 online resource (133 pages)

Source: Dissertations Abstracts International, Volume: 83-11, Section: B.

Thesis (Ph.D.)--Dartmouth College, 2022.

Includes bibliographical references

The theoretical framework of this thesis is that schizophrenia and alcohol use disorder may arise due to the presence of several risk factors in particular epochs in time throughout the development and the lifespan of an individual. These epochs include the individuals' genetic background, prenatal environment, infancy and early life, and adolescence. Due to the complicated nature of these disorders in humans, pre-clinical investigators have turned to rodent models in order to better tease apart the contributions of each risk factor on the behaviors and endophenotypes associated with disease. Through my research in this thesis, I target and manipulate three different developmental factors in rats in order to begin to elucidate how each contributes to aspects of schizophrenia and alcohol use disorder. The first factor that I assess is innate sex differences, and my first chapter shows that the neural circuit activity that is thought to underlie alcohol drinking behavior, as measured by local field potential oscillations, may be sexually dimorphic. The second factor that I manipulate is the neonatal development of the ventral hippocampus, thus creating a neurodevelopmental rat model of schizophrenia. The third factor that I manipulate is adolescence, and I do so via exposure to alcohol. My second chapter shows that exposure to adolescent alcohol does not affect nicotine behavioral sensitization in the neurodevelopmental rat model of schizophrenia. Last, my third chapter uses functional magnetic resonance imaging to measure functional connectivity in the rat model of schizophrenia and assesses the impact of acute alcohol and of adolescent alcohol exposure on connectivity measures.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798438758617Subjects--Topical Terms:

588700
Neurosciences.
Subjects--Index Terms:

Neurodevelopmental factorsIndex Terms--Genre/Form:

542853
Electronic books.

Neurodevelopmental Factors Contributing to Substance Use and Mental Illness.
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504 $a Includes bibliographical references
520 $a The theoretical framework of this thesis is that schizophrenia and alcohol use disorder may arise due to the presence of several risk factors in particular epochs in time throughout the development and the lifespan of an individual. These epochs include the individuals' genetic background, prenatal environment, infancy and early life, and adolescence. Due to the complicated nature of these disorders in humans, pre-clinical investigators have turned to rodent models in order to better tease apart the contributions of each risk factor on the behaviors and endophenotypes associated with disease. Through my research in this thesis, I target and manipulate three different developmental factors in rats in order to begin to elucidate how each contributes to aspects of schizophrenia and alcohol use disorder. The first factor that I assess is innate sex differences, and my first chapter shows that the neural circuit activity that is thought to underlie alcohol drinking behavior, as measured by local field potential oscillations, may be sexually dimorphic. The second factor that I manipulate is the neonatal development of the ventral hippocampus, thus creating a neurodevelopmental rat model of schizophrenia. The third factor that I manipulate is adolescence, and I do so via exposure to alcohol. My second chapter shows that exposure to adolescent alcohol does not affect nicotine behavioral sensitization in the neurodevelopmental rat model of schizophrenia. Last, my third chapter uses functional magnetic resonance imaging to measure functional connectivity in the rat model of schizophrenia and assesses the impact of acute alcohol and of adolescent alcohol exposure on connectivity measures.
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538 $a Mode of access: World Wide Web
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