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Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents./
作者:	Marciano, Yaron.
面頁冊數:	1 online resource (207 pages)
附註:	Source: Dissertations Abstracts International, Volume: 84-06, Section: B.
Contained By:	Dissertations Abstracts International84-06B.
標題:	Nanoscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=30242599click for full text (PQDT)
ISBN:	9798363514975

Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents.
Marciano, Yaron.

Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents. - 1 online resource (207 pages)

Source: Dissertations Abstracts International, Volume: 84-06, Section: B.

Thesis (Ph.D.)--City University of New York, 2023.

Includes bibliographical references

Enzyme-responsive materials have been well explored, particularly as therapeutic and diagnostic agents. In this thesis we demonstrate that anionic self-assembling peptides can be utilized as delivery vehicles for metal-based hydrophobic payloads. The tunability of the system is highlighted as well as the increase in cytotoxicity and selectivity in vitro. The rapid degradation of peptides in cell media may lead to the formation of new peptide-drug bioconjugates with increased activity and selectivity. The physiological stability of these peptide delivery vehicles has been optimized by capping the N-terminus with an acetyl group. This simple backbone modification was shown to not prevent self-assembly, the ability to load hydrophobic payloads, or modify the anticancer activity in vitro. This modification decreases peptide recognition by non- specific proteases, while retaining specificity towards an enzyme of interest (MMP-9). This highlights its potential as a stable enzyme-responsive delivery system.

Electronic reproduction.
Ann Arbor, Mich. :
ProQuest,
2023

Mode of access: World Wide Web

ISBN: 9798363514975Subjects--Topical Terms:

587832
Nanoscience.
Subjects--Index Terms:

CancerIndex Terms--Genre/Form:

542853
Electronic books.

Optimized Peptide Nanomaterials as Delivery Vehicles for Hydrophobic Metal-Based Anticancer Agents.
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504 $a Includes bibliographical references
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533 $a Electronic reproduction. $b Ann Arbor, Mich. : $c ProQuest, $d 2023
538 $a Mode of access: World Wide Web
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650 4 $a Analytical chemistry. $3 3168300
650 4 $a Inorganic chemistry. $3 3173556
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653 $a Enzyme of interest
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