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Emergence of Antibiotic Resistance in Microbial Populations with Spatial Heterogeneity.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Emergence of Antibiotic Resistance in Microbial Populations with Spatial Heterogeneity./
作者:	De Jong, Maxwell G.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	155 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-05, Section: B.
Contained By:	Dissertations Abstracts International83-05B.
標題:	Ecology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28845694
ISBN:	9798471105560

Emergence of Antibiotic Resistance in Microbial Populations with Spatial Heterogeneity.
De Jong, Maxwell G.

Emergence of Antibiotic Resistance in Microbial Populations with Spatial Heterogeneity. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 155 p.

Source: Dissertations Abstracts International, Volume: 83-05, Section: B.

Thesis (Ph.D.)--University of Michigan, 2021.

This item must not be sold to any third party vendors.

The emergence of antibiotic resistance in microbial populations is a complex evolutionary process dependent on a large number of factors, both mechanistic and external. We have modeled spatial heterogeneity as one such external factor and have found that it can greatly affect the times to resistance. We formed various models governed by simple atomistic rules in which antibiotic resistance can be treated as an emergent phenomenon and studied using classical tools from statistical mechanics, including a classical mean first passage time calculation and a kinetic Monte Carlo simulation. We have found that spatial heterogeneity can speed or slow the emergence of resistance, depending on the specific system and the relative rates of mutation and migration in spatially-extended systems. Finally, we developed a robust Bayesian inference pipeline to precisely estimate the relevant parameters from turbidostat evolution experiments. We believe that this work establishes environmental spatial heterogeneity as a critical factor in understanding the emergence of antibiotic resistance and may the groundwork for drug dosing strategies spatially-optimized to slow the emergence of resistance.

ISBN: 9798471105560Subjects--Topical Terms:

516476
Ecology.
Subjects--Index Terms:

Spatial heterogeneity

Emergence of Antibiotic Resistance in Microbial Populations with Spatial Heterogeneity.
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500 $a Source: Dissertations Abstracts International, Volume: 83-05, Section: B.
500 $a Advisor: Wood, Kevin.
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520 $a The emergence of antibiotic resistance in microbial populations is a complex evolutionary process dependent on a large number of factors, both mechanistic and external. We have modeled spatial heterogeneity as one such external factor and have found that it can greatly affect the times to resistance. We formed various models governed by simple atomistic rules in which antibiotic resistance can be treated as an emergent phenomenon and studied using classical tools from statistical mechanics, including a classical mean first passage time calculation and a kinetic Monte Carlo simulation. We have found that spatial heterogeneity can speed or slow the emergence of resistance, depending on the specific system and the relative rates of mutation and migration in spatially-extended systems. Finally, we developed a robust Bayesian inference pipeline to precisely estimate the relevant parameters from turbidostat evolution experiments. We believe that this work establishes environmental spatial heterogeneity as a critical factor in understanding the emergence of antibiotic resistance and may the groundwork for drug dosing strategies spatially-optimized to slow the emergence of resistance.
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650 4 $a Ecology. $3 516476
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650 4 $a Biophysics. $3 518360
650 4 $a Microbiology. $3 536250
650 4 $a Evolution & development. $3 3172418
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653 $a Antibiotic resistance
653 $a Evolutionary dynamics
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