東華大學圖書館 |

Complex Polymer Electrospun Nanofibers for Drug Delivery Applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Complex Polymer Electrospun Nanofibers for Drug Delivery Applications./
Author:	Heidari, Mina.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	165 p.
Notes:	Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
Contained By:	Dissertations Abstracts International84-01B.
Subject:	Tissue engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29180739
ISBN:	9798835550012

Complex Polymer Electrospun Nanofibers for Drug Delivery Applications.
Heidari, Mina.

Complex Polymer Electrospun Nanofibers for Drug Delivery Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 165 p.

Source: Dissertations Abstracts International, Volume: 84-01, Section: B.

Thesis (Ph.D.)--Universitaet Bayreuth (Germany), 2021.

This item must not be sold to any third party vendors.

Electrospinning has been introduced as an efficient technique for the fabrication of polymeric nanofibers. Electrospun nanofibrous structures have gained an unprecedented application among other nanostructures in drug delivery owing to their high surface area, which enable drugs to be adhered on the surface of the nanofibers. Our concept was to fabricate electrospun nanofibers and then immobilize drug-loaded polyeric micro- and nanoparticles into electrospun nanofibers. In our studies, artemisone (ART) as an antiplasmodial anti-inflamatory medication was used. By immobilizing ART into micro and nanocarriers, we aimed at increasing the stability as well as protecting the drug from degradation in aqueous medium and more importantly reducing the amount of burst release along with prolonging the release rate.We developed different carriers such as ART-loaded micro and nanoparticles synthesized by spray drying and solvent-displacement method. We were aiming at optimizing the governing parameters, which substantially influences particle size and encapsulation efficiency. It is important to produce particles with an efficient amount of drug and achieve the highest encapsulation efficiencies especially in case of ART, which is an expensive drug. Our concept was to immobilize these ART-loaded nanoparticles in electrospun nanofibers to evaluate whether we can merit from both advantages of nanoparticle and nanofiber. Our results proved our concept that the electrospun nanofibers immobilized with ART-loaded nanoparticles showed less burst release and more sustained release compared to nanoparticles and nanofibers itself. In other work, we tried to immobilize ART-loaded micro and nanoparticle in electrospun nanofibers simeltaneously by conducting suspension electrospinning to have an understanding of how the particle size impacts the ART release from electrospun nanofibers. Using this concept, the ART-loaded micro and nanoparticles immobilized in electrospun nanofibers revealed a less burst release and a more sustained release compared to fibers without particles. We also employed core-shell electrospinning as a concept to encapsulate ART into electrospun nanofibers. We achieved the core-shell structure, which resulted in a sustained release as well as less burst release compared to other systems. Lastly, we electrospun two types of cellulose namely MCC and CP, which resulted in obtaining nanofibers with a unique structure. The obtained nanofiber could be loaded with ART and find application for drug delivery.

ISBN: 9798835550012Subjects--Topical Terms:

823582
Tissue engineering.

Complex Polymer Electrospun Nanofibers for Drug Delivery Applications.
LDR:06793nmm a2200457 4500 001 2352418
005 20221128103648.5
008 241004s2021 ||||||||||||||||| ||eng d
020 $a 9798835550012
035 $a (MiAaPQ)AAI29180739
035 $a (MiAaPQ)UnivBayreuth_6022
035 $a AAI29180739
040 $a MiAaPQ $c MiAaPQ
100 1 $a Heidari, Mina. $3 3692042
245 1 0 $a Complex Polymer Electrospun Nanofibers for Drug Delivery Applications.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 165 p.
500 $a Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
500 $a Advisor: Keppler, Hans.
502 $a Thesis (Ph.D.)--Universitaet Bayreuth (Germany), 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Electrospinning has been introduced as an efficient technique for the fabrication of polymeric nanofibers. Electrospun nanofibrous structures have gained an unprecedented application among other nanostructures in drug delivery owing to their high surface area, which enable drugs to be adhered on the surface of the nanofibers. Our concept was to fabricate electrospun nanofibers and then immobilize drug-loaded polyeric micro- and nanoparticles into electrospun nanofibers. In our studies, artemisone (ART) as an antiplasmodial anti-inflamatory medication was used. By immobilizing ART into micro and nanocarriers, we aimed at increasing the stability as well as protecting the drug from degradation in aqueous medium and more importantly reducing the amount of burst release along with prolonging the release rate.We developed different carriers such as ART-loaded micro and nanoparticles synthesized by spray drying and solvent-displacement method. We were aiming at optimizing the governing parameters, which substantially influences particle size and encapsulation efficiency. It is important to produce particles with an efficient amount of drug and achieve the highest encapsulation efficiencies especially in case of ART, which is an expensive drug. Our concept was to immobilize these ART-loaded nanoparticles in electrospun nanofibers to evaluate whether we can merit from both advantages of nanoparticle and nanofiber. Our results proved our concept that the electrospun nanofibers immobilized with ART-loaded nanoparticles showed less burst release and more sustained release compared to nanoparticles and nanofibers itself. In other work, we tried to immobilize ART-loaded micro and nanoparticle in electrospun nanofibers simeltaneously by conducting suspension electrospinning to have an understanding of how the particle size impacts the ART release from electrospun nanofibers. Using this concept, the ART-loaded micro and nanoparticles immobilized in electrospun nanofibers revealed a less burst release and a more sustained release compared to fibers without particles. We also employed core-shell electrospinning as a concept to encapsulate ART into electrospun nanofibers. We achieved the core-shell structure, which resulted in a sustained release as well as less burst release compared to other systems. Lastly, we electrospun two types of cellulose namely MCC and CP, which resulted in obtaining nanofibers with a unique structure. The obtained nanofiber could be loaded with ART and find application for drug delivery.
520 $a Das Elektrospinnen wurde als effiziente Technik fur die Herstellung von polymeren Nanofasern eingefuhrt. Elektrogesponnene Nanofaserstrukturen haben aufgrund ihrer grosen Oberflache, die es ermoglicht, Arzneimittel auf der Oberflache der Nanofasern anzuheften, eine beispiellose Anwendung unter anderen Nanostrukturen fur die Arzneimittelverabreichung gefunden. Unser Konzept bestand darin, elektrogesponnene Nanofasern herzustellen und dann mit Medikamenten beladene polymere Mikro- und Nanopartikel in den elektrogesponnenen Nanofasern zu immobilisieren. In unseren Studien wurde Artemison (ART), ein entzundungshemmendes Medikament gegen Plasmodium, verwendet. Durch die Immobilisierung von ART in Mikro- und Nanocarrier wollten wir die Stabilitat erhohen und das Medikament vor dem Abbau in wassrigem Medium schutzen, und, was noch wichtiger ist, die Freisetzungsrate verlangern und die Menge des Freisetzungsstoses verringern.Wir entwickelten verschiedene Trager wie ART-beladene Mikro- und Nanopartikel, die durch Spruhtrocknung und Losungsmittelverdrangung hergestellt wurden. Unser Ziel war es, die masgeblichen Parameter zu optimieren, die die Partikelgrose und die Verkapselungseffizienz wesentlich beeinflussen. Es ist wichtig, Partikel mit einer effizienten Menge an Medikamenten herzustellen und die hochste Verkapselungseffizienz zu erreichen, insbesondere im Falle von ART, einem teuren Medikament. Unser Konzept bestand darin, diese mit ART beladenen Nanopartikel in elektrogesponnenen Nanofasern zu immobilisieren, um zu prufen, ob wir die Vorteile von Nanopartikeln und Nanofasern nutzen konnen. Unsere Ergebnisse bestatigten unser Konzept, dass die elektrogesponnenen Nanofasern, die mit ART-beladenen Nanopartikeln immobilisiert wurden, im Vergleich zu den Nanopartikeln und den Nanofasern selbst eine geringere sprunghafte und nachhaltigere Freisetzung zeigten. In einer anderen Arbeit haben wir versucht, ART-beladene Mikro- und Nanopartikel gleichzeitig in elektrogesponnenen Nanofasern zu immobilisieren, indem wir Suspensions-Elektrospinnen durchgefuhrt haben, um zu verstehen, wie die Partikelgrose die ART-Freisetzung aus elektrogesponnenen Nanofasern beeinflusst. Mit diesem Konzept zeigten die mit ART beladenen Mikro- und Nanopartikel, die in elektrogesponnenen Nanofasern immobilisiert waren, eine geringere Freisetzung und eine nachhaltigere Freisetzung im Vergleich zu Fasern ohne Partikel. Wir verwendeten auch das Konzept des Kern-Schale-Elektrospinnens, um ART in elektrogesponnene Nanofasern einzukapseln. Wir erreichten eine Kern-Schale-Struktur, die im Vergleich zu anderen Systemen zu einer anhaltenden Freisetzung und einer geringeren Freisetzung in Schuben fuhrte. Schlieslich haben wir zwei Arten von Zellulose, namlich MCC und CP, elektrogesponnen, wodurch wir Nanofasern mit einer einzigartigen Struktur erhalten haben. Die erhaltenen Nanofasern konnten mit ART beladen werden und fur die Verabreichung von Medikamenten eingesetzt werden.
590 $a School code: 5412.
650 4 $a Tissue engineering. $3 823582
650 4 $a Physiology. $3 518431
650 4 $a Mechanical properties. $3 3549505
650 4 $a Polymers. $3 535398
650 4 $a Polyesters. $3 686152
650 4 $a Acids. $3 922327
650 4 $a Drug interactions. $3 548667
650 4 $a Drug delivery systems. $3 657987
650 4 $a Water treatment. $3 3683746
650 4 $a Nanoparticles. $3 605747
650 4 $a Cellulose. $3 588995
650 4 $a Cancer therapies. $3 3557730
650 4 $a Solvents. $3 620946
650 4 $a Electric fields. $3 880423
650 4 $a Molecular weight. $3 3683783
650 4 $a Biodegradation. $3 705930
650 4 $a Peptides. $3 605772
650 4 $a Enzymes. $3 520899
650 4 $a Scanning electron microscopy. $3 551366
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Biology. $3 522710
650 4 $a Biomedical engineering. $3 535387
650 4 $a Chemistry. $3 516420
650 4 $a Engineering. $3 586835
650 4 $a Mechanics. $3 525881
650 4 $a Oncology. $3 751006
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Pharmacology. $3 634543
650 4 $a Physics. $3 516296
650 4 $a Plastics. $3 649803
650 4 $a Polymer chemistry. $3 3173488
690 $a 0719
690 $a 0486
690 $a 0306
690 $a 0541
690 $a 0485
690 $a 0537
690 $a 0346
690 $a 0992
690 $a 0572
690 $a 0419
690 $a 0605
690 $a 0795
690 $a 0495
710 2 $a Universitaet Bayreuth (Germany). $3 3545581
773 0 $t Dissertations Abstracts International $g 84-01B.
790 $a 5412
791 $a Ph.D.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29180739

	Simple Search
	Advanced Search
	Public Library Lists
	Public Reader Lists

	AcademicReservedBook [CH]
	BookLoanBillboard [CH]
	BookReservedBillboard [CH]
	Classification Browse [CH]
	Exhibition [CH]
	New books RSS feed [CH]

	Personal Details
	Saved Searches
	Recommendations
	Borrow/Reserve record
	Reviews
	Personal Lists
	ETIBS