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Complex Polymer Electrospun Nanofibers for Drug Delivery Applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Complex Polymer Electrospun Nanofibers for Drug Delivery Applications./
Author:	Heidari, Mina.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	165 p.
Notes:	Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
Contained By:	Dissertations Abstracts International84-01B.
Subject:	Tissue engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29180739
ISBN:	9798835550012

Complex Polymer Electrospun Nanofibers for Drug Delivery Applications.
Heidari, Mina.

Complex Polymer Electrospun Nanofibers for Drug Delivery Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 165 p.

Source: Dissertations Abstracts International, Volume: 84-01, Section: B.

Thesis (Ph.D.)--Universitaet Bayreuth (Germany), 2021.

This item must not be sold to any third party vendors.

Electrospinning has been introduced as an efficient technique for the fabrication of polymeric nanofibers. Electrospun nanofibrous structures have gained an unprecedented application among other nanostructures in drug delivery owing to their high surface area, which enable drugs to be adhered on the surface of the nanofibers. Our concept was to fabricate electrospun nanofibers and then immobilize drug-loaded polyeric micro- and nanoparticles into electrospun nanofibers. In our studies, artemisone (ART) as an antiplasmodial anti-inflamatory medication was used. By immobilizing ART into micro and nanocarriers, we aimed at increasing the stability as well as protecting the drug from degradation in aqueous medium and more importantly reducing the amount of burst release along with prolonging the release rate.We developed different carriers such as ART-loaded micro and nanoparticles synthesized by spray drying and solvent-displacement method. We were aiming at optimizing the governing parameters, which substantially influences particle size and encapsulation efficiency. It is important to produce particles with an efficient amount of drug and achieve the highest encapsulation efficiencies especially in case of ART, which is an expensive drug. Our concept was to immobilize these ART-loaded nanoparticles in electrospun nanofibers to evaluate whether we can merit from both advantages of nanoparticle and nanofiber. Our results proved our concept that the electrospun nanofibers immobilized with ART-loaded nanoparticles showed less burst release and more sustained release compared to nanoparticles and nanofibers itself. In other work, we tried to immobilize ART-loaded micro and nanoparticle in electrospun nanofibers simeltaneously by conducting suspension electrospinning to have an understanding of how the particle size impacts the ART release from electrospun nanofibers. Using this concept, the ART-loaded micro and nanoparticles immobilized in electrospun nanofibers revealed a less burst release and a more sustained release compared to fibers without particles. We also employed core-shell electrospinning as a concept to encapsulate ART into electrospun nanofibers. We achieved the core-shell structure, which resulted in a sustained release as well as less burst release compared to other systems. Lastly, we electrospun two types of cellulose namely MCC and CP, which resulted in obtaining nanofibers with a unique structure. The obtained nanofiber could be loaded with ART and find application for drug delivery.

ISBN: 9798835550012Subjects--Topical Terms:

823582
Tissue engineering.

Complex Polymer Electrospun Nanofibers for Drug Delivery Applications.
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245 1 0 $a Complex Polymer Electrospun Nanofibers for Drug Delivery Applications.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 165 p.
500 $a Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
500 $a Advisor: Keppler, Hans.
502 $a Thesis (Ph.D.)--Universitaet Bayreuth (Germany), 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Electrospinning has been introduced as an efficient technique for the fabrication of polymeric nanofibers. Electrospun nanofibrous structures have gained an unprecedented application among other nanostructures in drug delivery owing to their high surface area, which enable drugs to be adhered on the surface of the nanofibers. Our concept was to fabricate electrospun nanofibers and then immobilize drug-loaded polyeric micro- and nanoparticles into electrospun nanofibers. In our studies, artemisone (ART) as an antiplasmodial anti-inflamatory medication was used. By immobilizing ART into micro and nanocarriers, we aimed at increasing the stability as well as protecting the drug from degradation in aqueous medium and more importantly reducing the amount of burst release along with prolonging the release rate.We developed different carriers such as ART-loaded micro and nanoparticles synthesized by spray drying and solvent-displacement method. We were aiming at optimizing the governing parameters, which substantially influences particle size and encapsulation efficiency. It is important to produce particles with an efficient amount of drug and achieve the highest encapsulation efficiencies especially in case of ART, which is an expensive drug. Our concept was to immobilize these ART-loaded nanoparticles in electrospun nanofibers to evaluate whether we can merit from both advantages of nanoparticle and nanofiber. Our results proved our concept that the electrospun nanofibers immobilized with ART-loaded nanoparticles showed less burst release and more sustained release compared to nanoparticles and nanofibers itself. In other work, we tried to immobilize ART-loaded micro and nanoparticle in electrospun nanofibers simeltaneously by conducting suspension electrospinning to have an understanding of how the particle size impacts the ART release from electrospun nanofibers. Using this concept, the ART-loaded micro and nanoparticles immobilized in electrospun nanofibers revealed a less burst release and a more sustained release compared to fibers without particles. We also employed core-shell electrospinning as a concept to encapsulate ART into electrospun nanofibers. We achieved the core-shell structure, which resulted in a sustained release as well as less burst release compared to other systems. Lastly, we electrospun two types of cellulose namely MCC and CP, which resulted in obtaining nanofibers with a unique structure. The obtained nanofiber could be loaded with ART and find application for drug delivery.
520 $a Das Elektrospinnen wurde als effiziente Technik fur die Herstellung von polymeren Nanofasern eingefuhrt. Elektrogesponnene Nanofaserstrukturen haben aufgrund ihrer grosen Oberflache, die es ermoglicht, Arzneimittel auf der Oberflache der Nanofasern anzuheften, eine beispiellose Anwendung unter anderen Nanostrukturen fur die Arzneimittelverabreichung gefunden. Unser Konzept bestand darin, elektrogesponnene Nanofasern herzustellen und dann mit Medikamenten beladene polymere Mikro- und Nanopartikel in den elektrogesponnenen Nanofasern zu immobilisieren. In unseren Studien wurde Artemison (ART), ein entzundungshemmendes Medikament gegen Plasmodium, verwendet. Durch die Immobilisierung von ART in Mikro- und Nanocarrier wollten wir die Stabilitat erhohen und das Medikament vor dem Abbau in wassrigem Medium schutzen, und, was noch wichtiger ist, die Freisetzungsrate verlangern und die Menge des Freisetzungsstoses verringern.Wir entwickelten verschiedene Trager wie ART-beladene Mikro- und Nanopartikel, die durch Spruhtrocknung und Losungsmittelverdrangung hergestellt wurden. Unser Ziel war es, die masgeblichen Parameter zu optimieren, die die Partikelgrose und die Verkapselungseffizienz wesentlich beeinflussen. Es ist wichtig, Partikel mit einer effizienten Menge an Medikamenten herzustellen und die hochste Verkapselungseffizienz zu erreichen, insbesondere im Falle von ART, einem teuren Medikament. Unser Konzept bestand darin, diese mit ART beladenen Nanopartikel in elektrogesponnenen Nanofasern zu immobilisieren, um zu prufen, ob wir die Vorteile von Nanopartikeln und Nanofasern nutzen konnen. Unsere Ergebnisse bestatigten unser Konzept, dass die elektrogesponnenen Nanofasern, die mit ART-beladenen Nanopartikeln immobilisiert wurden, im Vergleich zu den Nanopartikeln und den Nanofasern selbst eine geringere sprunghafte und nachhaltigere Freisetzung zeigten. In einer anderen Arbeit haben wir versucht, ART-beladene Mikro- und Nanopartikel gleichzeitig in elektrogesponnenen Nanofasern zu immobilisieren, indem wir Suspensions-Elektrospinnen durchgefuhrt haben, um zu verstehen, wie die Partikelgrose die ART-Freisetzung aus elektrogesponnenen Nanofasern beeinflusst. Mit diesem Konzept zeigten die mit ART beladenen Mikro- und Nanopartikel, die in elektrogesponnenen Nanofasern immobilisiert waren, eine geringere Freisetzung und eine nachhaltigere Freisetzung im Vergleich zu Fasern ohne Partikel. Wir verwendeten auch das Konzept des Kern-Schale-Elektrospinnens, um ART in elektrogesponnene Nanofasern einzukapseln. Wir erreichten eine Kern-Schale-Struktur, die im Vergleich zu anderen Systemen zu einer anhaltenden Freisetzung und einer geringeren Freisetzung in Schuben fuhrte. Schlieslich haben wir zwei Arten von Zellulose, namlich MCC und CP, elektrogesponnen, wodurch wir Nanofasern mit einer einzigartigen Struktur erhalten haben. Die erhaltenen Nanofasern konnten mit ART beladen werden und fur die Verabreichung von Medikamenten eingesetzt werden.
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