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Understanding Muscle Function during in vivo Locomotion Using a Novel Muscle Avatar Approach.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Understanding Muscle Function during in vivo Locomotion Using a Novel Muscle Avatar Approach./
Author:	Rice, Nicole.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	41 p.
Notes:	Source: Masters Abstracts International, Volume: 82-03.
Contained By:	Masters Abstracts International82-03.
Subject:	Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28087659
ISBN:	9798664752106

Understanding Muscle Function during in vivo Locomotion Using a Novel Muscle Avatar Approach.
Rice, Nicole.

Understanding Muscle Function during in vivo Locomotion Using a Novel Muscle Avatar Approach. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 41 p.

Source: Masters Abstracts International, Volume: 82-03.

Thesis (M.S.)--Northern Arizona University, 2020.

This item must not be sold to any third party vendors.

Current ex vivo approaches to studying muscle function during dynamic locomotion fall short of producing realistic forces that emulate in vivo muscle function. Historically, muscles were studied using isometric and isotonic experiments, which later evolved into cyclical work loop studies that often use sinusoidal length inputs. In this study, we explore a new 'muscle avatar' method as the next step in the evolution of ex vivo muscle studies. One step down, two up steps, and a no barrier step, measured in vivo from the guinea fowl lateral gastrocnemius while the birds were running over barriers, were selected as strain trajectories to control ex vivo mouse extensor digitorum longus (EDL) muscles on a servomotor. Using these imposed bird trajectories, as well as a sinusoidal strain trajectory of the same strain amplitude and frequency, we ran the muscles through a series of work loop experiments with three different stimulation patterns (Normal, Late, Long). Ex vivo loops using the bird strain trajectories were far more similar than sinusoidal trajectories to the in vivo work loops. Activation, strain trajectory, and activation*strain trajectory interaction all had significant effects on work loop variables, but the interaction had the largest effect on most variables. In vivo strain trajectories imposed on mouse EDL also produced consistent work loops that show a shift in muscle function without changing activation phase. Up strain trajectories caused muscles to act as motors and produce large amounts of work, while the down strain trajectory dissipated energy and produced the least work. These results support the hypothesis that muscle is a viscoelastic material whose properties are tuned by activation, which changes resistance to deformation by applied loads, and force is produced in response to deformation of length.

ISBN: 9798664752106Subjects--Topical Terms:

518431
Physiology.
Subjects--Index Terms:

Activation

Understanding Muscle Function during in vivo Locomotion Using a Novel Muscle Avatar Approach.
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245 1 0 $a Understanding Muscle Function during in vivo Locomotion Using a Novel Muscle Avatar Approach.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 41 p.
500 $a Source: Masters Abstracts International, Volume: 82-03.
500 $a Advisor: Nishikawa, Kiisa.
502 $a Thesis (M.S.)--Northern Arizona University, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Current ex vivo approaches to studying muscle function during dynamic locomotion fall short of producing realistic forces that emulate in vivo muscle function. Historically, muscles were studied using isometric and isotonic experiments, which later evolved into cyclical work loop studies that often use sinusoidal length inputs. In this study, we explore a new 'muscle avatar' method as the next step in the evolution of ex vivo muscle studies. One step down, two up steps, and a no barrier step, measured in vivo from the guinea fowl lateral gastrocnemius while the birds were running over barriers, were selected as strain trajectories to control ex vivo mouse extensor digitorum longus (EDL) muscles on a servomotor. Using these imposed bird trajectories, as well as a sinusoidal strain trajectory of the same strain amplitude and frequency, we ran the muscles through a series of work loop experiments with three different stimulation patterns (Normal, Late, Long). Ex vivo loops using the bird strain trajectories were far more similar than sinusoidal trajectories to the in vivo work loops. Activation, strain trajectory, and activation*strain trajectory interaction all had significant effects on work loop variables, but the interaction had the largest effect on most variables. In vivo strain trajectories imposed on mouse EDL also produced consistent work loops that show a shift in muscle function without changing activation phase. Up strain trajectories caused muscles to act as motors and produce large amounts of work, while the down strain trajectory dissipated energy and produced the least work. These results support the hypothesis that muscle is a viscoelastic material whose properties are tuned by activation, which changes resistance to deformation by applied loads, and force is produced in response to deformation of length.
590 $a School code: 0391.
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650 4 $a Biomechanics. $3 548685
650 4 $a Biology. $3 522710
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653 $a Ex vivo
653 $a Muscle
653 $a Strain
653 $a Transient
653 $a Work loop
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793 $a English
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