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Biomarkers in Cardiac Magnetic Resonance Imaging: Indicators of Aging and Metabolic Function.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Biomarkers in Cardiac Magnetic Resonance Imaging: Indicators of Aging and Metabolic Function./
作者:	Moody, Alexander J.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	123 p.
附註:	Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
Contained By:	Dissertations Abstracts International84-01B.
標題:	Medical imaging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29213366
ISBN:	9798834033141

Biomarkers in Cardiac Magnetic Resonance Imaging: Indicators of Aging and Metabolic Function.
Moody, Alexander J.

Biomarkers in Cardiac Magnetic Resonance Imaging: Indicators of Aging and Metabolic Function. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 123 p.

Source: Dissertations Abstracts International, Volume: 84-01, Section: B.

Thesis (Ph.D.)--The University of Texas Health Science Center at San Antonio, 2022.

This item must not be sold to any third party vendors.

Cardiac Magnetic Resonance imaging (CMR) is a technique shown to accurately characterize function, structure, and composition in a metabolically deficient heart. The present study aims to demonstrate the sensitivity of CMR for cardiometabolic imaging applications in three parts: (i) measure the longitudinal effects of aging on cardiac function and myocardial strain in a baboon Intrauterine Growth Restriction (IUGR) model, (ii) evaluate the longitudinal progression of interstitial fibrosis in an IUGR baboon model with aging, and (iii) establish the effects of pioglitazone on cardiometabolic function and cardiac adiposity in Type 2 Diabetes Mellitus (T2DM). Baboon models were born from dams experiencing a 30% calorie reduction compared to control dams during gestation and nursing. After weaning, subjects were fed a normal caloric diet. CMR scans of baboon subjects were acquired in youth and again in late adulthood. Feature tracking image analysis was used to measure cardiac function and myocardial strain. Interstitial fibrosis was evaluated with a late-gadolinium enhanced T1-mapping method. In human subjects with T2DM, pioglitazone was used to ameliorate insulin resistance. The effects of pioglitazone on the cardiometabolic function were assessed as modulations in diastolic function and cardiac adiposity. Baboon subjects presented with decreased cardiac function and global myocardial strain in all directions in YOUTH, but recovered to a level similar to controls in MIDDLE AGE. Control function and strain remained constant from YOUTH to MIDDLE AGE. Improvements in systolic wall thickening velocity were significantly greater in IUGR compared to normal control subjects (p = 0.04). Ventricular sphericity remained relatively stable in control subjects, but was significantly elevated in IUGR between YOUTH and MIDDLE AGE by comparison (p = 0.03). Extracellular volume (ECV) of the myocardium increased globally from normal aging in both control (p = 0.02) and IUGR (p = 0.03). In human subjects with T2DM, pioglitazone significantly decreased insulin resistance, leading to ameliorations in epicardial adiposity (p = 0.03). The secondary effects of insulin resistance reduction were assessed as modulations in cardiac adiposity. The present study demonstrates three primary novel findings: (i) detrimental impacts from IUGR developmental programming on cardiac function and myocardial strain renormalize from YOUTH to MIDDLE AGE, (ii) progression of myocardial fibrosis and pathological ventricular remodeling (PVR) due to normal aging is accelerated in IUGR subjects compared to controls, and (iii) pioglitazone reduces insulin resistance, leading to reductions in cardiac adiposity associated with gains in myocardial function in T2DM. We propose that increased progression of PVR in IUGR causes an adaptative response that renormalizes cardiac function to supply bodily organs with sufficient blood flow. Additionally, pioglitazone interventions aimed at improving insulin tolerance are associated with ameliorations in cardiac adiposity.

ISBN: 9798834033141Subjects--Topical Terms:

3172799
Medical imaging.
Subjects--Index Terms:

Cardiac magnetic resonance imaging

Biomarkers in Cardiac Magnetic Resonance Imaging: Indicators of Aging and Metabolic Function.
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