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The Role of Dietary Folate Intake in Metabolism of Arsenic in Wild-Type C57BL/6N Mice and C57BL/6N Mice Carrying the Human AS3MT Gene.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Role of Dietary Folate Intake in Metabolism of Arsenic in Wild-Type C57BL/6N Mice and C57BL/6N Mice Carrying the Human AS3MT Gene./
Author:	Miller, Madison.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
Description:	82 p.
Notes:	Source: Masters Abstracts International, Volume: 83-11.
Contained By:	Masters Abstracts International83-11.
Subject:	Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29069083
ISBN:	9798438766933

The Role of Dietary Folate Intake in Metabolism of Arsenic in Wild-Type C57BL/6N Mice and C57BL/6N Mice Carrying the Human AS3MT Gene.
Miller, Madison.

The Role of Dietary Folate Intake in Metabolism of Arsenic in Wild-Type C57BL/6N Mice and C57BL/6N Mice Carrying the Human AS3MT Gene. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 82 p.

Source: Masters Abstracts International, Volume: 83-11.

Thesis (M.S.)--The University of North Carolina at Chapel Hill, 2022.

This item must not be sold to any third party vendors.

Chronic exposure to inorganic arsenic (iAs) is a public health concern and is associated with type 2 diabetes. iAs metabolism consists of methylation reactions catalyzed by arsenic methyltransferase (AS3MT) in most mammals. In humans, folate intake has been shown to affect iAs metabolism efficiency. Mouse models are commonly used to study iAs exposure, but mice are more efficient at metabolizing iAs than humans. This study examined a new mouse model carrying human AS3MT to better represent human iAs metabolism. We also assessed the role of folate in iAs metabolism and development of diabetic phenotypes in humanized and wild-type mice fed a folate deficient, adequate, or supplemented diet. We found that the humanized mice are a suitable model for human iAs metabolism but do not exhibit the same effects of folate intake on iAs metabolism seen in humans. Folate intake did not alter iAs metabolism efficiency in mice of either genotype.

ISBN: 9798438766933Subjects--Topical Terms:

517777
Nutrition.
Subjects--Index Terms:

Arsenic

The Role of Dietary Folate Intake in Metabolism of Arsenic in Wild-Type C57BL/6N Mice and C57BL/6N Mice Carrying the Human AS3MT Gene.
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245 1 4 $a The Role of Dietary Folate Intake in Metabolism of Arsenic in Wild-Type C57BL/6N Mice and C57BL/6N Mice Carrying the Human AS3MT Gene.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2022
300 $a 82 p.
500 $a Source: Masters Abstracts International, Volume: 83-11.
500 $a Advisor: Styblo, Mirek.
502 $a Thesis (M.S.)--The University of North Carolina at Chapel Hill, 2022.
506 $a This item must not be sold to any third party vendors.
520 $a Chronic exposure to inorganic arsenic (iAs) is a public health concern and is associated with type 2 diabetes. iAs metabolism consists of methylation reactions catalyzed by arsenic methyltransferase (AS3MT) in most mammals. In humans, folate intake has been shown to affect iAs metabolism efficiency. Mouse models are commonly used to study iAs exposure, but mice are more efficient at metabolizing iAs than humans. This study examined a new mouse model carrying human AS3MT to better represent human iAs metabolism. We also assessed the role of folate in iAs metabolism and development of diabetic phenotypes in humanized and wild-type mice fed a folate deficient, adequate, or supplemented diet. We found that the humanized mice are a suitable model for human iAs metabolism but do not exhibit the same effects of folate intake on iAs metabolism seen in humans. Folate intake did not alter iAs metabolism efficiency in mice of either genotype.
590 $a School code: 0153.
650 4 $a Nutrition. $3 517777
653 $a Arsenic
653 $a Folate intake
653 $a AS3MT
690 $a 0570
710 2 $a The University of North Carolina at Chapel Hill. $b Nutrition. $3 1020239
773 0 $t Masters Abstracts International $g 83-11.
790 $a 0153
791 $a M.S.
792 $a 2022
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29069083