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Molecular Mechanism of Pathogenic LRRK2 Membrane Recruitment.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Molecular Mechanism of Pathogenic LRRK2 Membrane Recruitment./
作者:	Vides, Edmundo Gabriel.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	162 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-09, Section: B.
Contained By:	Dissertations Abstracts International83-09B.
標題:	Membranes. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29003827
ISBN:	9798209788850

Molecular Mechanism of Pathogenic LRRK2 Membrane Recruitment.
Vides, Edmundo Gabriel.

Molecular Mechanism of Pathogenic LRRK2 Membrane Recruitment. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 162 p.

Source: Dissertations Abstracts International, Volume: 83-09, Section: B.

Thesis (Ph.D.)--Stanford University, 2021.

This item must not be sold to any third party vendors.

Activating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson's disease and we showed previously that activated LRRK2 phosphorylates a subset of Rab GTPases. Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there for both auto- and Rab substrate phosphorylation. Here we define the Rab29 binding region of the LRRK2 Armadillo domain and show that it can also bind additional LRRK2 substrates, Rab8A and 10. Moreover, we identify a distinct and higher affinity interaction interface between phosphorylated Rab8 and Rab10 within LRRK2's N-terminus that can retain LRRK2 on membranes in cells to catalyze multiple phosphorylation events. These findings reveal a feed-forward pathway that provides spatial control and apparent membrane activation of LRRK2 kinase activity.

ISBN: 9798209788850Subjects--Topical Terms:

1531702
Membranes.

Molecular Mechanism of Pathogenic LRRK2 Membrane Recruitment.
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500 $a Source: Dissertations Abstracts International, Volume: 83-09, Section: B.
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506 $a This item must not be sold to any third party vendors.
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650 4 $a Regulation. $3 3561775
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