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Dynamics of Collective Growth in the Drosophila Germline.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dynamics of Collective Growth in the Drosophila Germline./
Author:	Doherty, Caroline A.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	101 p.
Notes:	Source: Dissertations Abstracts International, Volume: 83-04, Section: B.
Contained By:	Dissertations Abstracts International83-04B.
Subject:	Molecular biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28716420
ISBN:	9798471107908

Dynamics of Collective Growth in the Drosophila Germline.
Doherty, Caroline A.

Dynamics of Collective Growth in the Drosophila Germline. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 101 p.

Source: Dissertations Abstracts International, Volume: 83-04, Section: B.

Thesis (Ph.D.)--Princeton University, 2021.

This item must not be sold to any third party vendors.

Developing oocytes need large supplies of macromolecules and organelles. A conserved strategy for accumulating these products is to pool resources of oocyte-associated nurse cells. In Drosophila, these cells grow more than 100-fold to boost their biosynthetic capacity. No previously known mechanism explains how nurse cells coordinate growth collectively. In this thesis I report a cell cycle-regulating mechanism that depends on bidirectional communication between the oocyte and nurse cells, revealing the oocyte as a critical regulator of germline cyst growth. Transcripts encoding the Cyclin-dependent kinase inhibitor Dacapo are synthesized by the nurse cells and actively localized to the oocyte. Retrograde movement of oocyte-synthesized Dacapo protein to the nurse cells generates a network of coupled oscillators that controls the cell cycle of the nurse cells to regulate cyst growth. I propose that bidirectional nurse cell-oocyte communication establishes a growth sensing feedback mechanism that regulates the quantity of maternal resources loaded into the oocyte. Furthermore, the nurse cells are not the only cells that engage in bidirectional communication with the oocyte. I present preliminary findings on how the mechanical properties of the cytoskeleton in the germline and overlying somatic follicle cells may coordinate growth of these two tissues. Finally, I expand on these experimental findings to discuss comparisons between Drosophila and mouse oogenesis and propose that bidirectional communication between oocytes and support cells is a universal feature of oogenesis across species.

ISBN: 9798471107908Subjects--Topical Terms:

517296
Molecular biology.
Subjects--Index Terms:

Oocytes

Dynamics of Collective Growth in the Drosophila Germline.
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100 1 $a Doherty, Caroline A. $3 3689277
245 1 0 $a Dynamics of Collective Growth in the Drosophila Germline.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 101 p.
500 $a Source: Dissertations Abstracts International, Volume: 83-04, Section: B.
500 $a Advisor: Shvartsman, Stanislav Y.;Gavis, Elizabeth R.
502 $a Thesis (Ph.D.)--Princeton University, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Developing oocytes need large supplies of macromolecules and organelles. A conserved strategy for accumulating these products is to pool resources of oocyte-associated nurse cells. In Drosophila, these cells grow more than 100-fold to boost their biosynthetic capacity. No previously known mechanism explains how nurse cells coordinate growth collectively. In this thesis I report a cell cycle-regulating mechanism that depends on bidirectional communication between the oocyte and nurse cells, revealing the oocyte as a critical regulator of germline cyst growth. Transcripts encoding the Cyclin-dependent kinase inhibitor Dacapo are synthesized by the nurse cells and actively localized to the oocyte. Retrograde movement of oocyte-synthesized Dacapo protein to the nurse cells generates a network of coupled oscillators that controls the cell cycle of the nurse cells to regulate cyst growth. I propose that bidirectional nurse cell-oocyte communication establishes a growth sensing feedback mechanism that regulates the quantity of maternal resources loaded into the oocyte. Furthermore, the nurse cells are not the only cells that engage in bidirectional communication with the oocyte. I present preliminary findings on how the mechanical properties of the cytoskeleton in the germline and overlying somatic follicle cells may coordinate growth of these two tissues. Finally, I expand on these experimental findings to discuss comparisons between Drosophila and mouse oogenesis and propose that bidirectional communication between oocytes and support cells is a universal feature of oogenesis across species.
590 $a School code: 0181.
650 4 $a Molecular biology. $3 517296
650 4 $a Systematic biology. $3 3173492
650 4 $a Developmental biology. $3 592588
653 $a Oocytes
653 $a Cell cycle-regulation
653 $a Nurse cells
653 $a Germline cyst growth
653 $a Bidirectional cellular communication
690 $a 0307
690 $a 0423
690 $a 0758
710 2 $a Princeton University. $b Molecular Biology. $3 2101701
773 0 $t Dissertations Abstracts International $g 83-04B.
790 $a 0181
791 $a Ph.D.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28716420