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Effects of N-3 polyunsaturated fatty acid supplementation during late gestation on BAT thermogenesis of newborn lambs.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Effects of N-3 polyunsaturated fatty acid supplementation during late gestation on BAT thermogenesis of newborn lambs./
作者:	Chen, Ching-Yi.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2003,
面頁冊數:	97 p.
附註:	Source: Dissertations Abstracts International, Volume: 65-04, Section: B.
Contained By:	Dissertations Abstracts International65-04B.
標題:	Livestock. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3088125
ISBN:	9780496358878

Effects of N-3 polyunsaturated fatty acid supplementation during late gestation on BAT thermogenesis of newborn lambs.
Chen, Ching-Yi.

Effects of N-3 polyunsaturated fatty acid supplementation during late gestation on BAT thermogenesis of newborn lambs. - Ann Arbor : ProQuest Dissertations & Theses, 2003 - 97 p.

Source: Dissertations Abstracts International, Volume: 65-04, Section: B.

Thesis (Ph.D.)--Texas A&M University, 2003.

This item must not be sold to any third party vendors.

Experiments were conducted to determine whether effects of dietary supplementation of n-3 polyunsaturated fatty acid (PUFA) during late gestation on recruitment of brown adipose tissue (BAT) in utero improves cold tolerance of newborn lambs. Thirty twin-bearing ewes were allotted beginning 40 ± 15 d prior to lambing. Groups were randomly assigned to treatments in a 3 x 2 factorial arrangement with factors being: level of rumen-protected fat (2, 4 or 8%), and source of rumen-protected fat (high in saturated/monosaturated fatty acid [SMFA; Energy Booster®] or high in n-3 PUFA; formaldehyde-protected soy/linseed lipid). Ewes were individually fed in an open-sided barn. Lambs were separated from ewes and placed in a warm chamber (25°C) within 2 h of age. At 4 h of age, all lambs were placed in a cold chamber (0°C) for 2 h and rectal temperature (RT) measured at 15-min intervals. One lamb per twin pair was killed at 6 h of age and the other lamb was returned to the warm chamber till 22 h of age. Cold-induced RT responses were again measured for 2 h and the second lamb killed at 24 h of age. Dietary PUFA supplementation increased plasma concentrations of 18:2 n-6, 18:3 n-3, and EPA of ewes, and increased the concentrations of EPA and DHA of lamb BAT. Thermogenesis, composition and cellularity of BAT were not changed by prenatal PUFA supplementation during late gestation. Lambs born to 2 and 4% PUFA-fed ewes had higher UCP1 mRNA than other lambs at 6 h of age. Rectal temperature response and GDP binding increased quadratically as level of prenatal fat increased. These results suggest that dietary supplementation of n-3 PUFA during late gestation modulated fatty acid profiles of ewe plasma and lamb BAT. Adding 4% fat to the diets of ewes during late gestation may enhance BAT thermogenesis, thereby improving cold tolerance in newborn lambs. Source of maternal fat supplementation had no effect on BAT thermogenesis of newborn lambs.

ISBN: 9780496358878Subjects--Topical Terms:

539534
Livestock.
Subjects--Index Terms:

Brown adipose tissue

Effects of N-3 polyunsaturated fatty acid supplementation during late gestation on BAT thermogenesis of newborn lambs.
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520 $a Experiments were conducted to determine whether effects of dietary supplementation of n-3 polyunsaturated fatty acid (PUFA) during late gestation on recruitment of brown adipose tissue (BAT) in utero improves cold tolerance of newborn lambs. Thirty twin-bearing ewes were allotted beginning 40 ± 15 d prior to lambing. Groups were randomly assigned to treatments in a 3 x 2 factorial arrangement with factors being: level of rumen-protected fat (2, 4 or 8%), and source of rumen-protected fat (high in saturated/monosaturated fatty acid [SMFA; Energy Booster®] or high in n-3 PUFA; formaldehyde-protected soy/linseed lipid). Ewes were individually fed in an open-sided barn. Lambs were separated from ewes and placed in a warm chamber (25°C) within 2 h of age. At 4 h of age, all lambs were placed in a cold chamber (0°C) for 2 h and rectal temperature (RT) measured at 15-min intervals. One lamb per twin pair was killed at 6 h of age and the other lamb was returned to the warm chamber till 22 h of age. Cold-induced RT responses were again measured for 2 h and the second lamb killed at 24 h of age. Dietary PUFA supplementation increased plasma concentrations of 18:2 n-6, 18:3 n-3, and EPA of ewes, and increased the concentrations of EPA and DHA of lamb BAT. Thermogenesis, composition and cellularity of BAT were not changed by prenatal PUFA supplementation during late gestation. Lambs born to 2 and 4% PUFA-fed ewes had higher UCP1 mRNA than other lambs at 6 h of age. Rectal temperature response and GDP binding increased quadratically as level of prenatal fat increased. These results suggest that dietary supplementation of n-3 PUFA during late gestation modulated fatty acid profiles of ewe plasma and lamb BAT. Adding 4% fat to the diets of ewes during late gestation may enhance BAT thermogenesis, thereby improving cold tolerance in newborn lambs. Source of maternal fat supplementation had no effect on BAT thermogenesis of newborn lambs.
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