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Genetic Influences of Reproductive Events in Cattle.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Genetic Influences of Reproductive Events in Cattle./
作者:	Lett, Beth M.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2022,
面頁冊數:	182 p.
附註:	Source: Dissertations Abstracts International, Volume: 84-01, Section: B.
Contained By:	Dissertations Abstracts International84-01B.
標題:	Animal sciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=29253948
ISBN:	9798834024330

Genetic Influences of Reproductive Events in Cattle.
Lett, Beth M.

Genetic Influences of Reproductive Events in Cattle. - Ann Arbor : ProQuest Dissertations & Theses, 2022 - 182 p.

Source: Dissertations Abstracts International, Volume: 84-01, Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2022.

This item must not be sold to any third party vendors.

Cattle are a primary livestock species for both milk (dairy) and meat (beef). A key factor influencing the production of either is reproduction. Identifying genetic influences on different reproductive events allows for non-invasive measures to improve reproductive efficiency. In this work three events: multiple births, embryo lethality, and ovulation rate, were explored for genetic contributions to those traits by utilizing different source of genomic materials. Estimation of twinning rate heritability and repeatability was conducted using North American Holstein Dairy cow calving records from 2010-2016. Identification of genomic regions associated with daughter averages for twinning were conducted using whole genome sequencing SNPs where a significant peak location was found on BTA11 and spans two candidate genes, LHCGR and FSHR. Next-generation pair-end sequencing reads were used to identify copy number variations (CNVs) within a small group of Jersey dairy cattle. Further these CNVs were screened for embryo lethal potential by identifying absence of homozygous deletion individuals. While the initial test of four deletions showed homozygotes there are 33 that remain of further interest and an additional 468 CNVs added to variant database. Lastly, screening for causal variant for the Trio allele, a major gene for high ovulation rate, was conducted on two individuals homozygous for the trait. The comparison involved screening Oxford nanopore long reads and Illumina pair-end short reads for SNPs, InDels, and structural variants. Results indicated one variant (10:g.13828552A>G) that was novel to only these two individuals when screened against the 1000 Bull Genome Project data. Further genotyping indicated high concordance between the variant and inferred Trio genotypes and absence in two non-Trio populations of interest. Connection of this variant with over-expression of SMAD-6 needs to be further tested.

ISBN: 9798834024330Subjects--Topical Terms:

3174829
Animal sciences.
Subjects--Index Terms:

Cattle

Genetic Influences of Reproductive Events in Cattle.
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