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Characterizing Disease with Contrast-Enhanced Ultrasound: Applications in Oncology and the Kidney.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Characterizing Disease with Contrast-Enhanced Ultrasound: Applications in Oncology and the Kidney./
作者:	Walmer, Rachel W.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	263 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-07, Section: B.
Contained By:	Dissertations Abstracts International83-07B.
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28722304
ISBN:	9798759980247

Characterizing Disease with Contrast-Enhanced Ultrasound: Applications in Oncology and the Kidney.
Walmer, Rachel W.

Characterizing Disease with Contrast-Enhanced Ultrasound: Applications in Oncology and the Kidney. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 263 p.

Source: Dissertations Abstracts International, Volume: 83-07, Section: B.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2021.

This item must not be sold to any third party vendors.

Early assessment of disease progression and response to therapy play an important role in patient health and contribute positively towards desired treatment outcomes. For cancer patients, imaging techniques that provide rapid feedback detailing therapeutic efficacy, particularly in the case of non-responsive or recurring tumors, allow clinicians to appropriately modify treatment regimens on a faster timescale. Current standards rely on changes in tumor volume, measured using computed tomography, to determine treatment response, an effective strategy against cytotoxic therapies. However, for targeted therapies, tumor volume may inadequately classify response while changes in molecular expression occur quite rapidly after treatment and may provide faster feedback regarding therapeutic response. Similarly, early detection strategies capable of identifying the presence and progression of kidney disease faster than current clinical markers could facilitate faster intervention and more effectively mitigate long-term tissue damage. With chronic kidney disease (CKD) progression, changes in renal perfusion in response to structural and functional kidney has potential as a strategy for early detection. Contrast-enhanced ultrasound (CEUS) imaging offers a portable, widely accessible, inexpensive, and safe method for quantifying vascular changes. Ultrasound contrast agent (microbubble) destruction imaging techniques used to measure changes in disease biomarkers such as blood perfusion or vascular endothelial receptor expression are widely-available and easily implemented on clinical systems. This dissertation focuses on the clinical adaptation of CEUS for disease detection and monitoring. The first hypothesis is that CEUS can monitor response to different cancer therapies more accurately than tumor volume, both in vivo and in clinically relevant populations. Enhancements such as acoustic radiation force, buried ligand architecture, and microbubble size-selection were applied to improve the sensitivity of ultrasound molecular imaging and aid in the clinical translation of this imaging technique. The second hypothesis is that CEUS can be used to diagnose kidney health through the early detection of kidney disease and can diagnose subsequent complications that arise from CKD. Here, flash-replenishment perfusion imaging was evaluated as a method for identifying kidney disease and characterizing kidney lesions in the presence of CKD. Together, the results presented in this work aid in the clinical advancement of CEUS imaging techniques for disease characterization.

ISBN: 9798759980247Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Disease characterization

Characterizing Disease with Contrast-Enhanced Ultrasound: Applications in Oncology and the Kidney.
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