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Hydrophilic Cargo-loaded Microbubbles for Ultrasound-triggered Local Delivery.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Hydrophilic Cargo-loaded Microbubbles for Ultrasound-triggered Local Delivery./
Author:	Chow, Samantha .
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	98 p.
Notes:	Source: Masters Abstracts International, Volume: 82-01.
Contained By:	Masters Abstracts International82-01.
Subject:	Bioengineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27737621
ISBN:	9798662391918

Hydrophilic Cargo-loaded Microbubbles for Ultrasound-triggered Local Delivery.
Chow, Samantha .

Hydrophilic Cargo-loaded Microbubbles for Ultrasound-triggered Local Delivery. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 98 p.

Source: Masters Abstracts International, Volume: 82-01.

Thesis (M.A.S.)--University of Toronto (Canada), 2020.

This item is not available from ProQuest Dissertations & Theses.

Microbubbles are intravenous ultrasound-responsive agents that can cavitate upon insonation. There is ongoing interest in incorporating hydrophilic therapeutic and imaging agents into microbubbles for local, ultrasound-triggered delivery. A proof-of-concept microbubble capable of carrying hydrophilic molecules, providing ultrasound contrast, and cavitating was designed. Calcein was selected as a model cargo for optical verification of co-localization. First, 75% v/v Span 80 and 25% v/v Tween 80 surfactants were selected to solubilize calcein in cyclooctane. Second, calcein-loaded oil was emulsified as microdroplets stabilized with 2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-5000] phospholipids. Microdroplets were lyophilized, decafluorobutane gas-filled, and saline reconstituted to form calcein-loaded microbubbles. These were characterized for size distribution, calcein loading, contrast enhancement and cavitation. Calcein-loaded microbubbles (peak: 4.3 μm) demonstrated cargo co-localization and a concentration per microbubble volume of 0.077±0.038 mg/mL. Microbubbles provided ultrasound contrast and underwent inertial cavitation at MI≥0.77. This synthesis method may be extended to encapsulate other hydrophilic cargo in acoustically-active carriers.

ISBN: 9798662391918Subjects--Topical Terms:

657580
Bioengineering.
Subjects--Index Terms:

Drug carrier

Hydrophilic Cargo-loaded Microbubbles for Ultrasound-triggered Local Delivery.
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245 1 0 $a Hydrophilic Cargo-loaded Microbubbles for Ultrasound-triggered Local Delivery.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 98 p.
500 $a Source: Masters Abstracts International, Volume: 82-01.
500 $a Advisor: Matsuura, Naomi.
502 $a Thesis (M.A.S.)--University of Toronto (Canada), 2020.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a Microbubbles are intravenous ultrasound-responsive agents that can cavitate upon insonation. There is ongoing interest in incorporating hydrophilic therapeutic and imaging agents into microbubbles for local, ultrasound-triggered delivery. A proof-of-concept microbubble capable of carrying hydrophilic molecules, providing ultrasound contrast, and cavitating was designed. Calcein was selected as a model cargo for optical verification of co-localization. First, 75% v/v Span 80 and 25% v/v Tween 80 surfactants were selected to solubilize calcein in cyclooctane. Second, calcein-loaded oil was emulsified as microdroplets stabilized with 2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-5000] phospholipids. Microdroplets were lyophilized, decafluorobutane gas-filled, and saline reconstituted to form calcein-loaded microbubbles. These were characterized for size distribution, calcein loading, contrast enhancement and cavitation. Calcein-loaded microbubbles (peak: 4.3 μm) demonstrated cargo co-localization and a concentration per microbubble volume of 0.077±0.038 mg/mL. Microbubbles provided ultrasound contrast and underwent inertial cavitation at MI≥0.77. This synthesis method may be extended to encapsulate other hydrophilic cargo in acoustically-active carriers.
590 $a School code: 0779.
650 4 $a Bioengineering. $3 657580
650 4 $a Medicine. $3 641104
650 4 $a Materials science. $3 543314
653 $a Drug carrier
653 $a Localized delivery
653 $a Ultrasound
690 $a 0202
690 $a 0564
690 $a 0794
710 2 $a University of Toronto (Canada). $b Materials Science and Engineering. $3 2093675
773 0 $t Masters Abstracts International $g 82-01.
790 $a 0779
791 $a M.A.S.
792 $a 2020
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=27737621