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imaging of targeted lipid microbubbles using third harmonic generation microscopy.

Record Type:	Electronic resources : Monograph/item
Title/Author:	imaging of targeted lipid microbubbles using third harmonic generation microscopy./
Author:	Harpel, Kaitlin G.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	46 p.
Notes:	Source: Masters Abstracts International, Volume: 78-01.
Contained By:	Masters Abstracts International78-01.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10118301
ISBN:	9781339796505

imaging of targeted lipid microbubbles using third harmonic generation microscopy.
Harpel, Kaitlin G.

imaging of targeted lipid microbubbles using third harmonic generation microscopy. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 46 p.

Source: Masters Abstracts International, Volume: 78-01.

Thesis (M.S.)--The University of Arizona, 2016.

This item must not be added to any third party search indexes.

The use of receptor-targeted lipid microbubbles imaged by ultrasound is an innovative method of detecting and localizing disease. However, since ultrasound requires a medium between the transducer and the object being imaged, it is impractical to apply to an exposed surface in a surgical setting where sterile fields need be maintained. Additionally, the application of an ultrasound gel to the imaging surface may cause the bubbles to collapse. Multiphoton microscopy (MPM) is an emerging tool for accurate imaging of tissues and cells with high resolution and contrast. We have recently developed a novel method for detecting targeted microbubble adherence to the upregulated plectin-receptor on pancreatic tumor cells using MPM. Specifically, the third-harmonic generation response can be used to detect bound microbubbles to various cell types presenting MPM as an alternative and useful imaging method. This is an interesting technique that can potentially be translated as a diagnostic tool for the early detection of cancer and inflammatory disorders.

ISBN: 9781339796505Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Confocal microscopy

imaging of targeted lipid microbubbles using third harmonic generation microscopy.
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020 $a 9781339796505
035 $a (MiAaPQ)AAI10118301
035 $a (MiAaPQ)arizona:14659
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100 1 $a Harpel, Kaitlin G. $3 3687336
245 1 0 $a imaging of targeted lipid microbubbles using third harmonic generation microscopy.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 46 p.
500 $a Source: Masters Abstracts International, Volume: 78-01.
500 $a Publisher info.: Dissertation/Thesis.
500 $a Advisor: Matsunaga, Terry O.
502 $a Thesis (M.S.)--The University of Arizona, 2016.
506 $a This item must not be added to any third party search indexes.
506 $a This item must not be sold to any third party vendors.
520 $a The use of receptor-targeted lipid microbubbles imaged by ultrasound is an innovative method of detecting and localizing disease. However, since ultrasound requires a medium between the transducer and the object being imaged, it is impractical to apply to an exposed surface in a surgical setting where sterile fields need be maintained. Additionally, the application of an ultrasound gel to the imaging surface may cause the bubbles to collapse. Multiphoton microscopy (MPM) is an emerging tool for accurate imaging of tissues and cells with high resolution and contrast. We have recently developed a novel method for detecting targeted microbubble adherence to the upregulated plectin-receptor on pancreatic tumor cells using MPM. Specifically, the third-harmonic generation response can be used to detect bound microbubbles to various cell types presenting MPM as an alternative and useful imaging method. This is an interesting technique that can potentially be translated as a diagnostic tool for the early detection of cancer and inflammatory disorders.
590 $a School code: 0009.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
650 4 $a Optics. $3 517925
653 $a Confocal microscopy
653 $a Microbubbles
653 $a Multiphoton microscopy
653 $a Pancreatic cancer
653 $a Plectin1 receptor
653 $a Third harmonic generation
690 $a 0541
690 $a 0574
690 $a 0752
710 2 $a The University of Arizona. $b Biomedical Engineering. $3 2092025
773 0 $t Masters Abstracts International $g 78-01.
790 $a 0009
791 $a M.S.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10118301