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Adaptive Designs for Complex Dose Finding Studies.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Adaptive Designs for Complex Dose Finding Studies./
Author:	Mozgunov, Pavel.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
Description:	230 p.
Notes:	Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
Contained By:	Dissertations Abstracts International80-06B.
Subject:	Statistics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=11018516
ISBN:	9798691298486

Adaptive Designs for Complex Dose Finding Studies.
Mozgunov, Pavel.

Adaptive Designs for Complex Dose Finding Studies. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 230 p.

Source: Dissertations Abstracts International, Volume: 80-06, Section: B.

Thesis (Ph.D.)--Lancaster University (United Kingdom), 2018.

This item must not be sold to any third party vendors.

The goal of an early phase clinical trial is to find the regimen (dose, combination, schedule, etc.) satisfying particular toxicity or (and) efficacy characteristics. Designs for trials studying doses of a single cytotoxic drug are based on the fundamental assumption "the more the better", that is, the toxicity and efficacy increase with the dose. This monotonicity assumption can be violated for novel therapies and for more advanced trials studying drug combinations or schedules. It also becomes common to consider a more complex endpoint rather than a binary one as they can carry more information about the drug. Both the violation of the monotonicity assumption and the complex outcomes give rise to important statistical challenges in designing novel clinical trials which require an extensive attention.In the first part of this thesis, we consider a specific class of combination trials which involve novel therapies and can benefit from the monotonicity assumption. We also propose a general tool evaluating the performance of novel designs in the context of complex clinical trials. Further, we consider a problem of Bayesian inference on restricted parameter spaces. We propose novel loss functions for parameters defined on the positive real line and on the interval demonstrating their performances in standard statistical problems. Based on the obtained results, we propose a novel allocation criterion for model-based designs that results in a more ethical allocation of patients.In the second part of this thesis, we consider a more general setting of early phase trials in which an investigator has no (or limited) information about the monotonic orderings of regimens' responses. Using an information-theoretic approach we derive novel regimen selection criteria which allow the avoidance of any parametric or monotonicity assumptions. We propose novel designs based on these criteria and show their consistency. We apply the proposed designs to Phase I, Phase II and Phase I/II clinical trials and compare their performances to currently used model-based methodologies.

ISBN: 9798691298486Subjects--Topical Terms:

517247
Statistics.
Subjects--Index Terms:

Information-theoretic approach

Adaptive Designs for Complex Dose Finding Studies.
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300 $a 230 p.
500 $a Source: Dissertations Abstracts International, Volume: 80-06, Section: B.
500 $a Advisor: Jaki, Thomas.
502 $a Thesis (Ph.D.)--Lancaster University (United Kingdom), 2018.
506 $a This item must not be sold to any third party vendors.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a The goal of an early phase clinical trial is to find the regimen (dose, combination, schedule, etc.) satisfying particular toxicity or (and) efficacy characteristics. Designs for trials studying doses of a single cytotoxic drug are based on the fundamental assumption "the more the better", that is, the toxicity and efficacy increase with the dose. This monotonicity assumption can be violated for novel therapies and for more advanced trials studying drug combinations or schedules. It also becomes common to consider a more complex endpoint rather than a binary one as they can carry more information about the drug. Both the violation of the monotonicity assumption and the complex outcomes give rise to important statistical challenges in designing novel clinical trials which require an extensive attention.In the first part of this thesis, we consider a specific class of combination trials which involve novel therapies and can benefit from the monotonicity assumption. We also propose a general tool evaluating the performance of novel designs in the context of complex clinical trials. Further, we consider a problem of Bayesian inference on restricted parameter spaces. We propose novel loss functions for parameters defined on the positive real line and on the interval demonstrating their performances in standard statistical problems. Based on the obtained results, we propose a novel allocation criterion for model-based designs that results in a more ethical allocation of patients.In the second part of this thesis, we consider a more general setting of early phase trials in which an investigator has no (or limited) information about the monotonic orderings of regimens' responses. Using an information-theoretic approach we derive novel regimen selection criteria which allow the avoidance of any parametric or monotonicity assumptions. We propose novel designs based on these criteria and show their consistency. We apply the proposed designs to Phase I, Phase II and Phase I/II clinical trials and compare their performances to currently used model-based methodologies.
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650 4 $a Sensitivity analysis. $3 3560752
650 4 $a Calibration. $3 2068745
650 4 $a Symmetry. $3 536815
650 4 $a Clinical trials. $3 724498
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650 4 $a Design specifications. $3 3683440
650 4 $a Drug dosages. $3 3557732
650 4 $a Asymmetry. $3 3562922
653 $a Information-theoretic approach
653 $a Novel clinical trials
653 $a Bayesian inference
653 $a Restricted parameter spaces
690 $a 0715
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710 2 $a Lancaster University (United Kingdom). $3 1294170
773 0 $t Dissertations Abstracts International $g 80-06B.
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