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Mechanisms and Effects of Femtosecond Laser Micromachining in Ophthalmic Materials and Ocular Tissue.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mechanisms and Effects of Femtosecond Laser Micromachining in Ophthalmic Materials and Ocular Tissue./
Author:	Yu, Dan.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	224 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-10, Section: B.
Contained By:	Dissertations Abstracts International82-10B.
Subject:	Biomedical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28322539
ISBN:	9798708749260

Mechanisms and Effects of Femtosecond Laser Micromachining in Ophthalmic Materials and Ocular Tissue.
Yu, Dan.

Mechanisms and Effects of Femtosecond Laser Micromachining in Ophthalmic Materials and Ocular Tissue. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 224 p.

Source: Dissertations Abstracts International, Volume: 82-10, Section: B.

Thesis (Ph.D.)--University of Rochester, 2021.

This item must not be sold to any third party vendors.

Femtosecond laser micromachining relies on tightly focused, low-energy laser pulses to locally modify material properties by nonlinear absorption and has been pioneered in the field of vision correction. Originating from femtosecond laser micromachining, intra-tissue refractive index shaping (IRIS) is a novel vision correction approach distinguished from all previous corneal refractive surgical techniques. After the success of inducing large refractive index changes in various ophthalmic materials, Blue-IRIS was tested in both excised corneas and live cats in vivo. While early work by the Knox research group has demonstrated the ability of creating refractive phase structures in both hydrogels and corneal tissue, explaining the physical and chemical phenomenon underlying the refractive index changes is still a challenge.This thesis work aimed to investigate the post-operative effects and the mechanisms of femtosecond laser micromachining in ophthalmic materials and ocular tissue. Besides characterizing the efficacy of femtosecond micromachining, this thesis focused on developing several measurement tools to study the local laser-material and laser-tissue interactions in a quantitative manner.The spectroscopic studies conducted in ophthalmic materials provided insights into the photochemical reactions under different laser irradiation regime, with an emphasis on the relationship between change in the local water content and induced refractive index changes. While the microscopic imaging and histochemistry studies demonstrated local modifications of fibrillar organization and composition, the effects of laser repetition rate on the tissue biological response was also evaluated. The findings in this thesis work can help gauge the potential of femtosecond laser micromachining as a clinical technique for the customization of refractive devices as well as for human vision correction.

ISBN: 9798708749260Subjects--Topical Terms:

535387
Biomedical engineering.
Subjects--Index Terms:

Femtosecond laser

Mechanisms and Effects of Femtosecond Laser Micromachining in Ophthalmic Materials and Ocular Tissue.
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500 $a Source: Dissertations Abstracts International, Volume: 82-10, Section: B.
500 $a Advisor: Knox, Wayne H.
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520 $a Femtosecond laser micromachining relies on tightly focused, low-energy laser pulses to locally modify material properties by nonlinear absorption and has been pioneered in the field of vision correction. Originating from femtosecond laser micromachining, intra-tissue refractive index shaping (IRIS) is a novel vision correction approach distinguished from all previous corneal refractive surgical techniques. After the success of inducing large refractive index changes in various ophthalmic materials, Blue-IRIS was tested in both excised corneas and live cats in vivo. While early work by the Knox research group has demonstrated the ability of creating refractive phase structures in both hydrogels and corneal tissue, explaining the physical and chemical phenomenon underlying the refractive index changes is still a challenge.This thesis work aimed to investigate the post-operative effects and the mechanisms of femtosecond laser micromachining in ophthalmic materials and ocular tissue. Besides characterizing the efficacy of femtosecond micromachining, this thesis focused on developing several measurement tools to study the local laser-material and laser-tissue interactions in a quantitative manner.The spectroscopic studies conducted in ophthalmic materials provided insights into the photochemical reactions under different laser irradiation regime, with an emphasis on the relationship between change in the local water content and induced refractive index changes. While the microscopic imaging and histochemistry studies demonstrated local modifications of fibrillar organization and composition, the effects of laser repetition rate on the tissue biological response was also evaluated. The findings in this thesis work can help gauge the potential of femtosecond laser micromachining as a clinical technique for the customization of refractive devices as well as for human vision correction.
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