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Determining the Factors Associated with Improved Outcomes in Patients with Spinal Cord Injury.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Determining the Factors Associated with Improved Outcomes in Patients with Spinal Cord Injury./
作者:
Yolcu, Yagiz Ugur.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:
118 p.
附註:
Source: Masters Abstracts International, Volume: 83-02.
Contained By:
Masters Abstracts International83-02.
標題:
Medicine. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28543536
ISBN:
9798534685220
Determining the Factors Associated with Improved Outcomes in Patients with Spinal Cord Injury.
Yolcu, Yagiz Ugur.
Determining the Factors Associated with Improved Outcomes in Patients with Spinal Cord Injury.
- Ann Arbor : ProQuest Dissertations & Theses, 2021 - 118 p.
Source: Masters Abstracts International, Volume: 83-02.
Thesis (M.S.)--College of Medicine - Mayo Clinic, 2021.
This item must not be sold to any third party vendors.
Spinal Cord Injury (SCI) is a challenging disorder to manage with complex associationsand numerous factors that can impact a patient's disease course. Currently, no effective treatmenthas been established even though substantial progresses are being made in basic and clinicalresearch. As one of the widely accepted and validated assessment tools, International Standardsfor Neurological Classification of Spinal Cord Injury (ISNCSCI) scores are frequently utilized totrack patient improvement as the primary endpoint in many clinical trials. However, failure ofstudies to translate into clinical practice despite significant differences in ISNCSCI score led tothe question whether every change in this scoring system should be significant. Therefore, wehave conducted a series of studies first to determine clinically important differences ISNCSCIscores using multiple approaches, followed by evaluating the impact of these scores on patients'perceived well-being in the long term utilizing predictive models. With regards to the clinicallyimportant differences, our findings demonstrated similar results for ISNCSCI scoring betweendifferent patient profiles. Overall, when the distribution-based approaches and anchor-basedapproaches were closer to each other, the motor score changes mainly stayed in the range of 5-10points. When these scores were used as cut-offs for ISNCSCI motor score change, it has impactedthe self-perceived health status and "Good/Excellent" general health rating for patients more thantheir satisfaction with life at the annual follow-up. However, predictive models utilized in thisstudy mainly had poor performances. Based on our current findings, we believe more emphasiscould be put on achieving certain levels of neurological improvement instead of a comparison ofthe raw scores to determine whether a patient is benefiting from an intervention or a treatment. Inaddition, future studies with better performing models are definitely needed to optimize thesefindings.
ISBN: 9798534685220Subjects--Topical Terms:
641104
Medicine.
Subjects--Index Terms:
Big data
Determining the Factors Associated with Improved Outcomes in Patients with Spinal Cord Injury.
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Spinal Cord Injury (SCI) is a challenging disorder to manage with complex associationsand numerous factors that can impact a patient's disease course. Currently, no effective treatmenthas been established even though substantial progresses are being made in basic and clinicalresearch. As one of the widely accepted and validated assessment tools, International Standardsfor Neurological Classification of Spinal Cord Injury (ISNCSCI) scores are frequently utilized totrack patient improvement as the primary endpoint in many clinical trials. However, failure ofstudies to translate into clinical practice despite significant differences in ISNCSCI score led tothe question whether every change in this scoring system should be significant. Therefore, wehave conducted a series of studies first to determine clinically important differences ISNCSCIscores using multiple approaches, followed by evaluating the impact of these scores on patients'perceived well-being in the long term utilizing predictive models. With regards to the clinicallyimportant differences, our findings demonstrated similar results for ISNCSCI scoring betweendifferent patient profiles. Overall, when the distribution-based approaches and anchor-basedapproaches were closer to each other, the motor score changes mainly stayed in the range of 5-10points. When these scores were used as cut-offs for ISNCSCI motor score change, it has impactedthe self-perceived health status and "Good/Excellent" general health rating for patients more thantheir satisfaction with life at the annual follow-up. However, predictive models utilized in thisstudy mainly had poor performances. Based on our current findings, we believe more emphasiscould be put on achieving certain levels of neurological improvement instead of a comparison ofthe raw scores to determine whether a patient is benefiting from an intervention or a treatment. Inaddition, future studies with better performing models are definitely needed to optimize thesefindings.
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28543536
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