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Ecological and Evolutionary Consequences of Exometabolties for Microbial Interactions.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Ecological and Evolutionary Consequences of Exometabolties for Microbial Interactions./
作者:	Chodkowski, John Luke.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	344 p.
附註:	Source: Dissertations Abstracts International, Volume: 83-03, Section: B.
Contained By:	Dissertations Abstracts International83-03B.
標題:	Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28713384
ISBN:	9798538123247

Ecological and Evolutionary Consequences of Exometabolties for Microbial Interactions.
Chodkowski, John Luke.

Ecological and Evolutionary Consequences of Exometabolties for Microbial Interactions. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 344 p.

Source: Dissertations Abstracts International, Volume: 83-03, Section: B.

Thesis (Ph.D.)--Michigan State University, 2021.

This item must not be sold to any third party vendors.

Interspecies interactions have fundamental roles in shaping microbial communities. Microbial community members can produce and release a diverse set of extracellular small molecules, collectively referred to as exometabolites. Interspecies interactions that result from exometabolites can alter the response and behaviors of microbial community members. This dissertation work demonstrates the establishment of a synthetic community system that facilitates the study of exometabolite-mediated interspecies interactions. This system was then used to understand the consequences of exometabolite-mediated interactions in a 3-member synthetic microbial community over stationary phase using a multi-omics approach. Lastly, an experimental evolution showed the consequences of long-term exometabolite interspecies interactions on the evolution of antibiotic resistance. This work advances knowledge on the dynamic response and behaviors of microbial community members' during non-growth states. This work also demonstrates how bacterial-bacterial interactions in a simple environment can lead to the emergence of antibiotic resistance.

ISBN: 9798538123247Subjects--Topical Terms:

536250
Microbiology.
Subjects--Index Terms:

Interspecies interactions

Ecological and Evolutionary Consequences of Exometabolties for Microbial Interactions.
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520 $a Interspecies interactions have fundamental roles in shaping microbial communities. Microbial community members can produce and release a diverse set of extracellular small molecules, collectively referred to as exometabolites. Interspecies interactions that result from exometabolites can alter the response and behaviors of microbial community members. This dissertation work demonstrates the establishment of a synthetic community system that facilitates the study of exometabolite-mediated interspecies interactions. This system was then used to understand the consequences of exometabolite-mediated interactions in a 3-member synthetic microbial community over stationary phase using a multi-omics approach. Lastly, an experimental evolution showed the consequences of long-term exometabolite interspecies interactions on the evolution of antibiotic resistance. This work advances knowledge on the dynamic response and behaviors of microbial community members' during non-growth states. This work also demonstrates how bacterial-bacterial interactions in a simple environment can lead to the emergence of antibiotic resistance.
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653 $a Evolution
653 $a Antibiotic resistance
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