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Synthesis and Characterization of Dinitrosyl Iron Compounds with Tris-Phosphine Based Ligands.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Synthesis and Characterization of Dinitrosyl Iron Compounds with Tris-Phosphine Based Ligands./
作者:	Sueme, William Ryan.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
面頁冊數:	113 p.
附註:	Source: Masters Abstracts International, Volume: 83-03.
Contained By:	Masters Abstracts International83-03.
標題:	Chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28410258
ISBN:	9798535530468

Synthesis and Characterization of Dinitrosyl Iron Compounds with Tris-Phosphine Based Ligands.
Sueme, William Ryan.

Synthesis and Characterization of Dinitrosyl Iron Compounds with Tris-Phosphine Based Ligands. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 113 p.

Source: Masters Abstracts International, Volume: 83-03.

Thesis (M.S.)--California State University, Long Beach, 2021.

This item must not be sold to any third party vendors.

Twelve new dinitrosyl iron compounds using tris-phosphine based ligands have been synthesized and characterized. The new compounds were synthesized using the following ligands enable to form mono and disubstituted DNIC's; Tris (2-furyl) phosphine, tris (o-methoxy phenyl) phosphine, tris (p-tolyl phenyl) phosphine, tris (o-tolyl phenyl) phosphine, tris (p-fluoro phenyl), and tris (p-methoxy phenyl) phosphine. These six compounds were chosen with the intention of synthesizing dinitrosyl iron compounds that possess some relative water solubility. Each of these compounds were characterized via infrared spectroscopy, ultraviolet-visible range spectroscopy, nuclear magnetic resonance and electro paramagnetic resonance. The purpose of the characterizations was to support the hypothesis of a successful synthesis of each compound. The overarching goal of this research is to establish water soluble DNIC's for less invasive medical treatments that incorporate nitric oxide as the key medicinal component. As this goal requires pinpoint accuracy in regard to drug design, a variety of similar ligands were chosen that will ideally allow for tunable drug design.

ISBN: 9798535530468Subjects--Topical Terms:

516420
Chemistry.
Subjects--Index Terms:

Dinitrosyl iron

Synthesis and Characterization of Dinitrosyl Iron Compounds with Tris-Phosphine Based Ligands.
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245 1 0 $a Synthesis and Characterization of Dinitrosyl Iron Compounds with Tris-Phosphine Based Ligands.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 113 p.
500 $a Source: Masters Abstracts International, Volume: 83-03.
500 $a Advisor: Li, Lijuan.
502 $a Thesis (M.S.)--California State University, Long Beach, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Twelve new dinitrosyl iron compounds using tris-phosphine based ligands have been synthesized and characterized. The new compounds were synthesized using the following ligands enable to form mono and disubstituted DNIC's; Tris (2-furyl) phosphine, tris (o-methoxy phenyl) phosphine, tris (p-tolyl phenyl) phosphine, tris (o-tolyl phenyl) phosphine, tris (p-fluoro phenyl), and tris (p-methoxy phenyl) phosphine. These six compounds were chosen with the intention of synthesizing dinitrosyl iron compounds that possess some relative water solubility. Each of these compounds were characterized via infrared spectroscopy, ultraviolet-visible range spectroscopy, nuclear magnetic resonance and electro paramagnetic resonance. The purpose of the characterizations was to support the hypothesis of a successful synthesis of each compound. The overarching goal of this research is to establish water soluble DNIC's for less invasive medical treatments that incorporate nitric oxide as the key medicinal component. As this goal requires pinpoint accuracy in regard to drug design, a variety of similar ligands were chosen that will ideally allow for tunable drug design.
590 $a School code: 6080.
650 4 $a Chemistry. $3 516420
650 4 $a Research. $3 531893
650 4 $a Physiology. $3 518431
650 4 $a Pollutants. $3 551065
650 4 $a Enzyme kinetics. $3 536022
650 4 $a Cytotoxicity. $3 3682273
650 4 $a Free radicals. $3 3682274
650 4 $a Heart failure. $3 804127
650 4 $a Carbon monoxide. $3 738287
650 4 $a Amino acids. $3 558768
650 4 $a Nitrogen. $3 1314426
650 4 $a Alzheimers disease. $3 3560855
650 4 $a Proteins. $3 558769
650 4 $a Hemoglobin. $3 1012003
650 4 $a Mammals. $3 531989
650 4 $a Spectrum analysis. $3 520440
650 4 $a Oxidation. $3 714629
650 4 $a Hypotheses. $3 3560118
650 4 $a Endothelium. $3 1898152
650 4 $a Antimicrobial agents. $3 3556833
650 4 $a Design. $3 518875
650 4 $a Ligands. $3 686413
650 4 $a Chemical bonds. $3 560512
650 4 $a Nitric oxide. $3 750512
653 $a Dinitrosyl iron
653 $a DNIC
653 $a Ligand
653 $a Nitric oxide
653 $a Phosphine
690 $a 0485
690 $a 0389
690 $a 0719
710 2 $a California State University, Long Beach. $b Chemistry and Biochemistry. $3 3181224
773 0 $t Masters Abstracts International $g 83-03.
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