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ENTRAPMENT OF BIOACTIVE COMPOUNDS WITHIN NATIVE ALBUMIN BEADS.

Record Type:	Electronic resources : Monograph/item
Title/Author:	ENTRAPMENT OF BIOACTIVE COMPOUNDS WITHIN NATIVE ALBUMIN BEADS./
Author:	SHEU, MING-THAU.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 1986,
Description:	139 p.
Notes:	Source: Dissertations Abstracts International, Volume: 47-07, Section: B.
Contained By:	Dissertations Abstracts International47-07B.
Subject:	Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8618849
ISBN:	9798206489682

ENTRAPMENT OF BIOACTIVE COMPOUNDS WITHIN NATIVE ALBUMIN BEADS.
SHEU, MING-THAU.

ENTRAPMENT OF BIOACTIVE COMPOUNDS WITHIN NATIVE ALBUMIN BEADS. - Ann Arbor : ProQuest Dissertations & Theses, 1986 - 139 p.

Source: Dissertations Abstracts International, Volume: 47-07, Section: B.

Thesis (Ph.D.)--The Ohio State University, 1986.

This item must not be sold to any third party vendors.

A simple process has been developed for preparing albumin microbeads without aggregation. The resulting beads can be dispersed easily in water. It was found that serum albumin concentrations of 200 mg per ml of a sodium phosphate buffer (pH = 7.5, 10 mM) and 1% glutaraldehyde is an ideal combination permitting a reaction time of 20-30 seconds before addition to, and emulsification in, an oil phase. A subsequent curing time of around 30 minutes appears sufficient. These beads have proven to be digestible, safe, and effective carrier. The release of drug can be controlled through the use of different sized beads. Different sizes are made by controlling the viscosity and/or the interfacial tension of the oil phases used. A mixture of oleic acid and light mineral oil provide a series of oil phases with different interfacial tensions and mixtures of light and heavy mineral oil provide different viscosities. The systems are simple and reliably reproduced. The rate limiting step in the release process of drug appears to be rate penetration of water inward. Release can be described by an exponential dependence of time. Although there is a distribution of sizes in a batch of prepared microbeads, a single statistical size, the weight-moment mean diameter, of the distribution can be used to describe the release of drug based on release dependent on water permeation. Calculated diffusion coefficient is found to decrease slightly with increasing the extent of crosslinking and to decrease with a increase in weight-moment mean diameter. There is a small effect of drug loading on diffusion coefficient. 5'-deoxy-5-fluorouridine has been successfully covalently bound through an ester link to preformed microbeads using 1-ethyl-3-(3-dimethylamino propyl) carbodiimide as the dehydrating agent. The release of bound 5'-deoxy-5-fluorouridine has been extended considerably having a half life of about a day compared to just a few minutes of drug merely physically entrapped.

ISBN: 9798206489682Subjects--Topical Terms:

634543
Pharmacology.

ENTRAPMENT OF BIOACTIVE COMPOUNDS WITHIN NATIVE ALBUMIN BEADS.
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020 $a 9798206489682
035 $a (MiAaPQ)AAI8618849
035 $a AAI8618849
040 $a MiAaPQ $c MiAaPQ
100 1 $a SHEU, MING-THAU. $3 3680584
245 1 0 $a ENTRAPMENT OF BIOACTIVE COMPOUNDS WITHIN NATIVE ALBUMIN BEADS.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 1986
300 $a 139 p.
500 $a Source: Dissertations Abstracts International, Volume: 47-07, Section: B.
500 $a Publisher info.: Dissertation/Thesis.
502 $a Thesis (Ph.D.)--The Ohio State University, 1986.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a A simple process has been developed for preparing albumin microbeads without aggregation. The resulting beads can be dispersed easily in water. It was found that serum albumin concentrations of 200 mg per ml of a sodium phosphate buffer (pH = 7.5, 10 mM) and 1% glutaraldehyde is an ideal combination permitting a reaction time of 20-30 seconds before addition to, and emulsification in, an oil phase. A subsequent curing time of around 30 minutes appears sufficient. These beads have proven to be digestible, safe, and effective carrier. The release of drug can be controlled through the use of different sized beads. Different sizes are made by controlling the viscosity and/or the interfacial tension of the oil phases used. A mixture of oleic acid and light mineral oil provide a series of oil phases with different interfacial tensions and mixtures of light and heavy mineral oil provide different viscosities. The systems are simple and reliably reproduced. The rate limiting step in the release process of drug appears to be rate penetration of water inward. Release can be described by an exponential dependence of time. Although there is a distribution of sizes in a batch of prepared microbeads, a single statistical size, the weight-moment mean diameter, of the distribution can be used to describe the release of drug based on release dependent on water permeation. Calculated diffusion coefficient is found to decrease slightly with increasing the extent of crosslinking and to decrease with a increase in weight-moment mean diameter. There is a small effect of drug loading on diffusion coefficient. 5'-deoxy-5-fluorouridine has been successfully covalently bound through an ester link to preformed microbeads using 1-ethyl-3-(3-dimethylamino propyl) carbodiimide as the dehydrating agent. The release of bound 5'-deoxy-5-fluorouridine has been extended considerably having a half life of about a day compared to just a few minutes of drug merely physically entrapped.
590 $a School code: 0168.
650 4 $a Pharmacology. $3 634543
690 $a 0490
710 2 $a The Ohio State University. $3 718944
773 0 $t Dissertations Abstracts International $g 47-07B.
790 $a 0168
791 $a Ph.D.
792 $a 1986
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8618849