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Elucidating the Interfacial Interactions Between Biomacromolecules and Functionalized PAMAM-Based Materials for Biomedical Applications.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Elucidating the Interfacial Interactions Between Biomacromolecules and Functionalized PAMAM-Based Materials for Biomedical Applications./
Author:	Simms, Briana LaChae'.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2021,
Description:	182 p.
Notes:	Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
Contained By:	Dissertations Abstracts International82-12B.
Subject:	Polymer chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28496497
ISBN:	9798516097294

Elucidating the Interfacial Interactions Between Biomacromolecules and Functionalized PAMAM-Based Materials for Biomedical Applications.
Simms, Briana LaChae'.

Elucidating the Interfacial Interactions Between Biomacromolecules and Functionalized PAMAM-Based Materials for Biomedical Applications. - Ann Arbor : ProQuest Dissertations & Theses, 2021 - 182 p.

Source: Dissertations Abstracts International, Volume: 82-12, Section: B.

Thesis (Ph.D.)--The University of Mississippi, 2021.

This item must not be sold to any third party vendors.

Polyamidoamine (PAMAM) is a dendrimer structure with a polypeptide backbone architecture. It has been utilized in a wide variety of applications but has found significant utility in biomedical applications. PAMAM has been studied extensively due to its globular structure that is similar to proteins found in the body. The branched architecture and overall size provide a favorable environment for host-guest interactions and allows for the loading of small molecules for therapeutic delivery. Although PAMAM has many benefits for use in the area of therapeutic delivery, a primary area of concern for this molecular architecture is the terminal amines that serve as the end-groups for the branches. At physiological conditions, these terminal amines are protonated resulting in a positive surface charge density on the dendritic structure. These protonated amines are a primary source of toxicity associated with PAMAM dendrimers. Literature shows that too high of a positive surface charge density can lead to various forms of toxicity, such as cell lysis. Specific to PAMAM dendrimers, the size and generation of the dendrimer dramatically affects the ability for this macromolecule to interact with negatively charged biological components leading to myotoxicity or the disruption the secondary structure of proteins.To utilize the advantageous properties of PAMAM, significant efforts have been made by scientists to decrease the overall positive surface charge density of PAMAM dendrimers. Post-functionalization of PAMAM with moieties such as polyethylene glycol, glucose derivatives, or even reversible binding of biological components such as DNA via electrostatic interactions have proven to be successful routes to decrease the overall toxicity of PAMAM.The drawback of using systems such as these is that these modifications require for the backbone architecture of PAMAM to be altered, thus changing the physiochemical properties of the dendritic structure. In this body of work, we highlight the design of nanocarriers that incorporate the PAMAM structure as a primary component on the polymeric system. We explore the effects of terminal end-group modifications to the PAMAM structure to elucidate the interfacial interactions between biomacromolecules and functionalized-PAMAM biomaterials, without altering the polypeptide backbone architecture of the dendrimer. This allows us to take advantage of the favorable properties of PAMAM, decrease the overall positive surface charge density of PAMAM, and better understand how surface modifications can affect the physiochemical properties of PAMAM dendrimers.

ISBN: 9798516097294Subjects--Topical Terms:

3173488
Polymer chemistry.
Subjects--Index Terms:

Drug delivery

Elucidating the Interfacial Interactions Between Biomacromolecules and Functionalized PAMAM-Based Materials for Biomedical Applications.
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245 1 0 $a Elucidating the Interfacial Interactions Between Biomacromolecules and Functionalized PAMAM-Based Materials for Biomedical Applications.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2021
300 $a 182 p.
500 $a Source: Dissertations Abstracts International, Volume: 82-12, Section: B.
500 $a Advisor: Watkins, Davita L.
502 $a Thesis (Ph.D.)--The University of Mississippi, 2021.
506 $a This item must not be sold to any third party vendors.
520 $a Polyamidoamine (PAMAM) is a dendrimer structure with a polypeptide backbone architecture. It has been utilized in a wide variety of applications but has found significant utility in biomedical applications. PAMAM has been studied extensively due to its globular structure that is similar to proteins found in the body. The branched architecture and overall size provide a favorable environment for host-guest interactions and allows for the loading of small molecules for therapeutic delivery. Although PAMAM has many benefits for use in the area of therapeutic delivery, a primary area of concern for this molecular architecture is the terminal amines that serve as the end-groups for the branches. At physiological conditions, these terminal amines are protonated resulting in a positive surface charge density on the dendritic structure. These protonated amines are a primary source of toxicity associated with PAMAM dendrimers. Literature shows that too high of a positive surface charge density can lead to various forms of toxicity, such as cell lysis. Specific to PAMAM dendrimers, the size and generation of the dendrimer dramatically affects the ability for this macromolecule to interact with negatively charged biological components leading to myotoxicity or the disruption the secondary structure of proteins.To utilize the advantageous properties of PAMAM, significant efforts have been made by scientists to decrease the overall positive surface charge density of PAMAM dendrimers. Post-functionalization of PAMAM with moieties such as polyethylene glycol, glucose derivatives, or even reversible binding of biological components such as DNA via electrostatic interactions have proven to be successful routes to decrease the overall toxicity of PAMAM.The drawback of using systems such as these is that these modifications require for the backbone architecture of PAMAM to be altered, thus changing the physiochemical properties of the dendritic structure. In this body of work, we highlight the design of nanocarriers that incorporate the PAMAM structure as a primary component on the polymeric system. We explore the effects of terminal end-group modifications to the PAMAM structure to elucidate the interfacial interactions between biomacromolecules and functionalized-PAMAM biomaterials, without altering the polypeptide backbone architecture of the dendrimer. This allows us to take advantage of the favorable properties of PAMAM, decrease the overall positive surface charge density of PAMAM, and better understand how surface modifications can affect the physiochemical properties of PAMAM dendrimers.
590 $a School code: 0131.
650 4 $a Polymer chemistry. $3 3173488
650 4 $a Materials science. $3 543314
653 $a Drug delivery
653 $a Linear dendritic block copolymers
653 $a Polyamidoamine
690 $a 0794
690 $a 0495
710 2 $a The University of Mississippi. $b Chemistry. $3 3435760
773 0 $t Dissertations Abstracts International $g 82-12B.
790 $a 0131
791 $a Ph.D.
792 $a 2021
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28496497