東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Purinergic receptors and their modul...

Colotta, Vittoria.

FindBook

Google Book

Amazon

博客來

Purinergic receptors and their modulators

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Purinergic receptors and their modulators/ edited by Vittoria Colotta, Claudiu T. Supuran.
其他作者:	Colotta, Vittoria.
出版者:	Cham :Springer International Publishing : : 2023.,
面頁冊數:	x, 354 p. :ill., digital ;24 cm.
內容註:	Once upon a time adenosine and its receptors. Historical survey and perspectives as potential targets for therapy in human diseases -- Adenosine receptor ligands, probes and functional conjugates: A twenty-year history of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines (PTP) -- Adenosine receptor ligands as potential therapeutic agents for impaired wound healing and fibrosis -- Adenosine A2A receptor antagonists: chemistry, SARs, modeling studies and therapeutic potential -- A2B Adenosine Receptor as a new and attractive target to treat brain ischemia or demyelination -- A3 adenosine receptor ligands: from discovery to clinical trials -- Bifunctional tools to study adenosine receptors -- Allosteric modulators of adenosine receptors -- New computational approaches in inspecting adenosine receptor-ligand recognition process -- P2X4 receptors in immunity and inflammation -- CD73 inhibitors as antitumor agents -- Bacterial ectonucleotidases- underexplored antibacterial targets.
Contained By:	Springer Nature eBook
標題:	Purines - Receptors. -
電子資源:	https://doi.org/10.1007/978-3-031-39725-7
ISBN:	9783031397257

Purinergic receptors and their modulators
Purinergic receptors and their modulators[electronic resource] /edited by Vittoria Colotta, Claudiu T. Supuran. - Cham :Springer International Publishing :2023. - x, 354 p. :ill., digital ;24 cm. - Topics in medicinal chemistry,v. 411862-247X ;. - Topics in medicinal chemistry ;v. 41..

Once upon a time adenosine and its receptors. Historical survey and perspectives as potential targets for therapy in human diseases -- Adenosine receptor ligands, probes and functional conjugates: A twenty-year history of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines (PTP) -- Adenosine receptor ligands as potential therapeutic agents for impaired wound healing and fibrosis -- Adenosine A2A receptor antagonists: chemistry, SARs, modeling studies and therapeutic potential -- A2B Adenosine Receptor as a new and attractive target to treat brain ischemia or demyelination -- A3 adenosine receptor ligands: from discovery to clinical trials -- Bifunctional tools to study adenosine receptors -- Allosteric modulators of adenosine receptors -- New computational approaches in inspecting adenosine receptor-ligand recognition process -- P2X4 receptors in immunity and inflammation -- CD73 inhibitors as antitumor agents -- Bacterial ectonucleotidases- underexplored antibacterial targets.

This book overviews purinergic receptors that are playing key roles in human and pathophysiological processes. The book elaborates on how selective P1 and P2 modulators have been developed as therapeutics for a variety of diseases. It also provides an overview of current perspectives in the design of purinergic receptor modulators and future challenges such as the availability of selective ligands for all receptor subtypes. Divided into 12 chapters, this comprehensive volume also offers a multidisciplinary perspective on the historical evolution, starting with a chapter devoted to the roots and early discoveries of adenosine and its receptors, followed by a twenty-year retrospective on the synthesis, properties, and functional potential of adenosine receptor ligands, probes, and functional conjugates. In the next chapters, experts in the field delve into topics such as the therapeutic potential of adenosine receptor ligands in wound healing and fibrosis, the therapeutic benefits of A2A receptor antagonists, the A2B adenosine receptor as a target for brain ischemia or demyelination, the development and latest advancements in clinical trials of A3 adenosine receptor ligands. Other chapters describe bifunctional tools to study adenosine receptors, allosteric modulators of adenosine receptors, and new computational approaches to inspect adenosine receptor-ligand recognition processes. Furthermore, the book discusses the role of P2X4 receptors in immunity and inflammation. The final chapters illustrate CD73 inhibitors as antitumor agents, and bacterial ectonucleotidases as underexplored antibacterial drug targets. This book is a valuable resource for scholars working in the field of medicinal chemistry, as well as researchers in the industry, providing readers with a comprehensive understanding of adenosine receptor biology and its therapeutic potential.

ISBN: 9783031397257

Standard No.: 10.1007/978-3-031-39725-7doiSubjects--Topical Terms:

3662587
Purines
--Receptors.

LC Class. No.: QP801.P8

Dewey Class. No.: 547.596

Purinergic receptors and their modulators
LDR:03958nmm a2200349 a 4500 001 2334434
003 DE-He213
005 20230928194942.0
006 m d
007 cr nn 008maaau
008 240402s2023 sz s 0 eng d
020 $a 9783031397257 $q (electronic bk.)
020 $a 9783031397240 $q (paper)
024 7 $a 10.1007/978-3-031-39725-7 $2 doi
035 $a 978-3-031-39725-7
040 $a GP $c GP
041 0 $a eng
050 4 $a QP801.P8
072 7 $a PNN $2 bicssc
072 7 $a PSB $2 bicssc
072 7 $a SCI013020 $2 bisacsh
072 7 $a PNB $2 thema
082 0 4 $a 547.596 $2 23
090 $a QP801.P8 $b P985 2023
245 0 0 $a Purinergic receptors and their modulators $h [electronic resource] / $c edited by Vittoria Colotta, Claudiu T. Supuran.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2023.
300 $a x, 354 p. : $b ill., digital ; $c 24 cm.
490 1 $a Topics in medicinal chemistry, $x 1862-247X ; $v v. 41
505 0 $a Once upon a time adenosine and its receptors. Historical survey and perspectives as potential targets for therapy in human diseases -- Adenosine receptor ligands, probes and functional conjugates: A twenty-year history of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines (PTP) -- Adenosine receptor ligands as potential therapeutic agents for impaired wound healing and fibrosis -- Adenosine A2A receptor antagonists: chemistry, SARs, modeling studies and therapeutic potential -- A2B Adenosine Receptor as a new and attractive target to treat brain ischemia or demyelination -- A3 adenosine receptor ligands: from discovery to clinical trials -- Bifunctional tools to study adenosine receptors -- Allosteric modulators of adenosine receptors -- New computational approaches in inspecting adenosine receptor-ligand recognition process -- P2X4 receptors in immunity and inflammation -- CD73 inhibitors as antitumor agents -- Bacterial ectonucleotidases- underexplored antibacterial targets.
520 $a This book overviews purinergic receptors that are playing key roles in human and pathophysiological processes. The book elaborates on how selective P1 and P2 modulators have been developed as therapeutics for a variety of diseases. It also provides an overview of current perspectives in the design of purinergic receptor modulators and future challenges such as the availability of selective ligands for all receptor subtypes. Divided into 12 chapters, this comprehensive volume also offers a multidisciplinary perspective on the historical evolution, starting with a chapter devoted to the roots and early discoveries of adenosine and its receptors, followed by a twenty-year retrospective on the synthesis, properties, and functional potential of adenosine receptor ligands, probes, and functional conjugates. In the next chapters, experts in the field delve into topics such as the therapeutic potential of adenosine receptor ligands in wound healing and fibrosis, the therapeutic benefits of A2A receptor antagonists, the A2B adenosine receptor as a target for brain ischemia or demyelination, the development and latest advancements in clinical trials of A3 adenosine receptor ligands. Other chapters describe bifunctional tools to study adenosine receptors, allosteric modulators of adenosine receptors, and new computational approaches to inspect adenosine receptor-ligand recognition processes. Furthermore, the book discusses the role of P2X4 receptors in immunity and inflammation. The final chapters illustrate CD73 inhibitors as antitumor agents, and bacterial ectonucleotidases as underexplored antibacterial drug targets. This book is a valuable resource for scholars working in the field of medicinal chemistry, as well as researchers in the industry, providing readers with a comprehensive understanding of adenosine receptor biology and its therapeutic potential.
650 0 $a Purines $x Receptors. $3 3662587
650 0 $a Biological response modifiers. $3 662992
650 1 4 $a Medicinal Chemistry. $3 892420
650 2 4 $a Chemical Biology. $3 3602593
650 2 4 $a Biological Sciences. $3 1363809
700 1 $a Colotta, Vittoria. $3 3666015
700 1 $a Supuran, Claudiu T. $3 3218078
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a Topics in medicinal chemistry ; $v v. 41. $3 3666016
856 4 0 $u https://doi.org/10.1007/978-3-031-39725-7
950 $a Chemistry and Materials Science (SpringerNature-11644)