東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Pharmacology of drug stereoisomers

Spasov, Alexander A.

FindBook

Google Book

Amazon

博客來

Pharmacology of drug stereoisomers

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Pharmacology of drug stereoisomers/ by Alexander A. Spasov ... [et al.].
其他作者:	Spasov, Alexander A.
出版者:	Singapore :Springer Nature Singapore : : 2022.,
面頁冊數:	xi, 207 p. :ill., digital ;24 cm.
內容註:	Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
Contained By:	Springer Nature eBook
標題:	Pharmacology. -
電子資源:	https://doi.org/10.1007/978-981-19-2320-3
ISBN:	9789811923203

Pharmacology of drug stereoisomers
Pharmacology of drug stereoisomers[electronic resource] /by Alexander A. Spasov ... [et al.]. - Singapore :Springer Nature Singapore :2022. - xi, 207 p. :ill., digital ;24 cm. - Progress in drug research,v. 762297-4555 ;. - Progress in drug research ;v. 76..

Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.

The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers) Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.

ISBN: 9789811923203

Standard No.: 10.1007/978-981-19-2320-3doiSubjects--Topical Terms:

634543
Pharmacology.

LC Class. No.: RM300

Dewey Class. No.: 615.1

Pharmacology of drug stereoisomers
LDR:02507nmm a2200337 a 4500 001 2303734
003 DE-He213
005 20220910081256.0
006 m d
007 cr nn 008maaau
008 230409s2022 si s 0 eng d
020 $a 9789811923203 $q (electronic bk.)
020 $a 9789811923197 $q (paper)
024 7 $a 10.1007/978-981-19-2320-3 $2 doi
035 $a 978-981-19-2320-3
040 $a GP $c GP
041 0 $a eng
050 4 $a RM300
072 7 $a MMG $2 bicssc
072 7 $a MED071000 $2 bisacsh
072 7 $a MKG $2 thema
082 0 4 $a 615.1 $2 23
090 $a RM300 $b .P536 2022
245 0 0 $a Pharmacology of drug stereoisomers $h [electronic resource] / $c by Alexander A. Spasov ... [et al.].
260 $a Singapore : $b Springer Nature Singapore : $b Imprint: Springer, $c 2022.
300 $a xi, 207 p. : $b ill., digital ; $c 24 cm.
490 1 $a Progress in drug research, $x 2297-4555 ; $v v. 76
505 0 $a Preface -- General principles of chirality -- Quantitative methods of analysing chirality drugs - Chirality and pharmacokinetics -- Drugs regulating the function of peripheral nervous system -- In silico search for chiral drug compounds.
520 $a The book is devoted to an important aspect of pharmacology and pharmaceutical chemistry, i.e. the significance of stereoisomerism of drugs for their biological effect from the point of view of their pharmacokinetics, pharmacodynamics and toxicology. The authors review the landmarks in the development of stereochemistry and stereopharmacology. Present-day IUPAC terminology is discussed; general issues of stereoisomerism are considered including separation of racemic mixtures and asymmetric synthesis of isomers, methods of quantifying the isomers of a drug in biological material. The authors put special emphasis on general problems of the influence of stereoisomerism on pharmacological and adverse effects of drugs. A classification of drugs based on stereochemical properties of their isomers is proposed. Possibilities of interaction of stereoisomers in racemic mixtures are discussed. A considerable portion of the book is devoted to pharmacological action of the main groups of drugs whose structure includes asymmetric atoms (that is, drugs with several isomers) Detailed attention is paid to advisability of developing single isomer drugs and to the specifics of their study at the stage of preclinical and clinical trials.
650 0 $a Pharmacology. $3 634543
650 0 $a Stereoisomers $x Therapeutic use. $3 3605270
650 0 $a Stereoisomers $x Physiological effect. $3 3605271
650 2 4 $a Medicinal Chemistry. $3 892420
650 2 4 $a Pharmaceutics. $3 3538434
650 2 4 $a Biotechnology. $3 571461
650 2 4 $a Bioprocess Engineering. $3 3591868
700 1 $a Spasov, Alexander A. $3 3605268
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer Nature eBook
830 0 $a Progress in drug research ; $v v. 76. $3 3605269
856 4 0 $u https://doi.org/10.1007/978-981-19-2320-3
950 $a Biomedical and Life Sciences (SpringerNature-11642)