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Mathematical models of cell-based mo...

Honda, Hisao.

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Mathematical models of cell-based morphogenesis = passive and active remodeling /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Mathematical models of cell-based morphogenesis/ by Hisao Honda, Tatsuzo Nagai.
Reminder of title:	passive and active remodeling /
Author:	Honda, Hisao.
other author:	Nagai, Tatsuzo.
Published:	Singapore :Springer Nature Singapore : : 2022.,
Description:	viii, 192 p. :ill., digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Morphogenesis - Mathematical models. -
Online resource:	https://doi.org/10.1007/978-981-19-2916-8
ISBN:	9789811929168

Mathematical models of cell-based morphogenesis = passive and active remodeling /
Honda, Hisao.

Mathematical models of cell-based morphogenesispassive and active remodeling /[electronic resource] :by Hisao Honda, Tatsuzo Nagai. - Singapore :Springer Nature Singapore :2022. - viii, 192 p. :ill., digital ;24 cm. - Theoretical biology,2522-0446. - Theoretical biology..

This book describes the shape formation of living organisms using mathematical models. Genes are deeply related to the shape of living organisms, and elucidation of a pathway of shape formation from genes is one of the fundamental problems in biology. Mathematical cell models are indispensable tools to elucidate this problem. The book introduces two mathematical cell models, the cell center model and the vertex model, with their applications. The cell center model is applied to elucidate the formation of neat cell arrangements in epidermis, cell patterns consisting of heterogeneous-sized cells, capillary networks, and the branching patterns of blood vessels. The vertex model is applied to elucidate the wound healing mechanisms of the epithelium and ordered pattern formation involving apoptosis. Pattern formation with differential cell adhesion is also described. The vertex model is then extended from a two-dimensional (2D) to a three-dimensional (3D) model. A cell aggregate involving a large cavity is described to explain the development of the mammalian blastocyst or the formation of an epithelial vesicle. Epithelial tissues and the polarity formation process of the epithelium are also explained. The vertex model also recapitulates active remodeling of tissues and describes the twisting of tissue that contributes to understanding the cardiac loop formation of the embryonic tube. The book showcases that mathematical cell models are indispensable tools to understand the shape formation of living organisms. Successful contribution of the mathematical cell models means that the remodeling of collective cells is self-construction. Examining the successive iterations of self-constructions leads to understanding the remarkable and mysterious morphogenesis that occurs during the development of living organisms. The intended readers of this book are not only theoretical or mathematical biologists, but also experimental and general biologists, including undergraduate and postgraduate students who are interested in the relationship between genes and morphogenesis.

ISBN: 9789811929168

Standard No.: 10.1007/978-981-19-2916-8doiSubjects--Topical Terms:

3601408
Morphogenesis
--Mathematical models.

LC Class. No.: QH491 / .H65 2022

Dewey Class. No.: 571.833

Mathematical models of cell-based morphogenesis = passive and active remodeling /
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520 $a This book describes the shape formation of living organisms using mathematical models. Genes are deeply related to the shape of living organisms, and elucidation of a pathway of shape formation from genes is one of the fundamental problems in biology. Mathematical cell models are indispensable tools to elucidate this problem. The book introduces two mathematical cell models, the cell center model and the vertex model, with their applications. The cell center model is applied to elucidate the formation of neat cell arrangements in epidermis, cell patterns consisting of heterogeneous-sized cells, capillary networks, and the branching patterns of blood vessels. The vertex model is applied to elucidate the wound healing mechanisms of the epithelium and ordered pattern formation involving apoptosis. Pattern formation with differential cell adhesion is also described. The vertex model is then extended from a two-dimensional (2D) to a three-dimensional (3D) model. A cell aggregate involving a large cavity is described to explain the development of the mammalian blastocyst or the formation of an epithelial vesicle. Epithelial tissues and the polarity formation process of the epithelium are also explained. The vertex model also recapitulates active remodeling of tissues and describes the twisting of tissue that contributes to understanding the cardiac loop formation of the embryonic tube. The book showcases that mathematical cell models are indispensable tools to understand the shape formation of living organisms. Successful contribution of the mathematical cell models means that the remodeling of collective cells is self-construction. Examining the successive iterations of self-constructions leads to understanding the remarkable and mysterious morphogenesis that occurs during the development of living organisms. The intended readers of this book are not only theoretical or mathematical biologists, but also experimental and general biologists, including undergraduate and postgraduate students who are interested in the relationship between genes and morphogenesis.
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