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Antimalarial natural products

Kinghorn, A. Douglas.

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Antimalarial natural products

Record Type:	Electronic resources : Monograph/item
Title/Author:	Antimalarial natural products/ edited by A. Douglas Kinghorn ... [et al.].
other author:	Kinghorn, A. Douglas.
Published:	Cham :Springer International Publishing : : 2022.,
Description:	ix, 106 p. :ill. (some col.), digital ;24 cm.
Contained By:	Springer Nature eBook
Subject:	Antimalarials. -
Online resource:	https://doi.org/10.1007/978-3-030-89873-1
ISBN:	9783030898731

Antimalarial natural products
Antimalarial natural products[electronic resource] /edited by A. Douglas Kinghorn ... [et al.]. - Cham :Springer International Publishing :2022. - ix, 106 p. :ill. (some col.), digital ;24 cm. - Progress in the chemistry of organic natural products,v. 1172192-4309 ;. - Progress in the chemistry of organic natural products ;v. 117..

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.

ISBN: 9783030898731

Standard No.: 10.1007/978-3-030-89873-1doiSubjects--Topical Terms:

895439
Antimalarials.

LC Class. No.: RC159.A5

Dewey Class. No.: 616.9362061

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520 $a This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine's biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine's structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature's combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends by identifying ten natural products with development potential as clinical antimalarial agents.
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650 1 4 $a Organic Chemistry. $3 890856
650 2 4 $a Biochemistry, general. $3 890840
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