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Development Towards an Ethylene Sens...

Ellinwood, Mitchell Lee.

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Development Towards an Ethylene Sensing Artificial Metalloenzyme.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Development Towards an Ethylene Sensing Artificial Metalloenzyme./
Author:	Ellinwood, Mitchell Lee.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2020,
Description:	120 p.
Notes:	Source: Masters Abstracts International, Volume: 82-08.
Contained By:	Masters Abstracts International82-08.
Subject:	Organic chemistry. -
Online resource:	https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28157128
ISBN:	9798569905409

Development Towards an Ethylene Sensing Artificial Metalloenzyme.
Ellinwood, Mitchell Lee.

Development Towards an Ethylene Sensing Artificial Metalloenzyme. - Ann Arbor : ProQuest Dissertations & Theses, 2020 - 120 p.

Source: Masters Abstracts International, Volume: 82-08.

Thesis (M.S.)--University of Denver, 2020.

This item must not be sold to any third party vendors.

Ethylene (ethene) is the essential ripening hormone for climacteric plants, and consequently its detection and quantification is of considerable interest to the horticulture industry. Its detection however is a non-trivial pursuit, traditionally requiring expensive and inaccessible instrumentation that fail to provide in vivo information about ethylene. A ruthenium based fluorescent probe for the selective detection of ethylene has recently been developed, and it was envisioned that this probe could be made biocompatible by encasing it within a protein scaffold making it an artificial metalloenzyme. To this end biotinylated N-heterocyclic carbenes (NHCs) were synthesized, which can be appended onto the ruthenium probe. Efforts towards the expression and purification of the protein scaffold are also here reported.Mycofactocin (MFT) is a ribosomally synthesized and post-translationally modified peptide (RiPP) hypothesized to function as a redox cofactor in bacteria, particularly the Mycobacteria genus, which includes M. tuberculosis. In order to further elucidate the function of MFT and its associated proteins, a synthetic route was desired to the small molecule. A viable synthetic route to MFT, pre-MFT (PMFT) and other structural analogues is here reported.

ISBN: 9798569905409Subjects--Topical Terms:

523952
Organic chemistry.
Subjects--Index Terms:

Mycofactocin

Development Towards an Ethylene Sensing Artificial Metalloenzyme.
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100 1 $a Ellinwood, Mitchell Lee. $3 3564804
245 1 0 $a Development Towards an Ethylene Sensing Artificial Metalloenzyme.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2020
300 $a 120 p.
500 $a Source: Masters Abstracts International, Volume: 82-08.
500 $a Advisor: Michel, Brian.
502 $a Thesis (M.S.)--University of Denver, 2020.
506 $a This item must not be sold to any third party vendors.
520 $a Ethylene (ethene) is the essential ripening hormone for climacteric plants, and consequently its detection and quantification is of considerable interest to the horticulture industry. Its detection however is a non-trivial pursuit, traditionally requiring expensive and inaccessible instrumentation that fail to provide in vivo information about ethylene. A ruthenium based fluorescent probe for the selective detection of ethylene has recently been developed, and it was envisioned that this probe could be made biocompatible by encasing it within a protein scaffold making it an artificial metalloenzyme. To this end biotinylated N-heterocyclic carbenes (NHCs) were synthesized, which can be appended onto the ruthenium probe. Efforts towards the expression and purification of the protein scaffold are also here reported.Mycofactocin (MFT) is a ribosomally synthesized and post-translationally modified peptide (RiPP) hypothesized to function as a redox cofactor in bacteria, particularly the Mycobacteria genus, which includes M. tuberculosis. In order to further elucidate the function of MFT and its associated proteins, a synthetic route was desired to the small molecule. A viable synthetic route to MFT, pre-MFT (PMFT) and other structural analogues is here reported.
590 $a School code: 0061.
650 4 $a Organic chemistry. $3 523952
650 4 $a Horticulture. $3 555447
650 4 $a Biochemistry. $3 518028
653 $a Mycofactocin
653 $a Climacteric plants
653 $a N-heterocyclic carbenes
653 $a Metalloenzyme
690 $a 0490
690 $a 0487
690 $a 0471
710 2 $a University of Denver. $b Chemistry and Biochemistry. $3 3546673
773 0 $t Masters Abstracts International $g 82-08.
790 $a 0061
791 $a M.S.
792 $a 2020
793 $a English
856 4 0 $u https://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=28157128